Vesicle-like Nanocapsules Formed by Self-Assembly of Peptides with Oligoproline and -Leucine DOI

Yui Okamoto,

Masahiro Higuchi,

S. Matsubara

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(24), P. 12802 - 12809

Published: June 8, 2024

Since drug carriers are envisaged to be used in a wide variety of situations and environments, nanocarriers with diverse properties, such as biocompatibility, biodegradability, nonimmunogenicity, adequate particle size, robustness, cell permeability, required. Here, we report the construction novel nanocapsules above-mentioned features by self-assembly peptides composed oligoproline oligoleucine (i.e., H-Pro10Leu4-NH2 H-Pro10Leu6-NH2). The self-organized via hydrogen bonds hydrophobic interactions between moieties form vesicle-like cationic exposed on surface. guest encapsulation experiments revealed that were capable uptake both water-soluble insoluble compounds. Furthermore, positively charged and/or oligoproline-based known improve permeability cellular uptake, suggesting peptide good candidates for complement liposomes polymer micelles.

Language: Английский

Cupric-polymeric Nanoreactors Integrate into Copper Metabolism to Promote Chronic Diabetic Wounds Healing DOI Creative Commons
Qi Tang, Yinqiu Tan,

Shaolong Leng

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101087 - 101087

Published: May 11, 2024

Given multifunction of copper (Cu) contributing to all stages the physiology wound healing, Cu-based compounds have great therapeutic potentials accelerate but they must be limited a very low concentration range avoid detrimental accumulation. Additionally, cellular mechanism participating healing process remains elusive. In this study, oxide nanoparticles (CuONPs) were synthesized mimic multiple natural enzymes and trapped into PEG-

Language: Английский

Citations

4
Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound DOI
Wenyu Wang, Zhipeng Li, Chaolong Liu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

Citations

2
How Nanoparticles Help in Combating Chronic Wound Biofilms Infection? DOI Creative Commons

Gang Jing,

Chen Hu,

Keyi Fang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11883 - 11921

Published: Nov. 1, 2024

Chronic wound infection has become a global health problem, with bacterial biofilms, which are difficult to penetrate using traditional antibiotics, considered the primary cause of recurrent and delayed healing in chronic wounds. In recent years, outstanding performance nanomaterials controlling biofilm infections been widely acknowledged, these materials regarded as highly promising for management. The formation structure biofilms undergo complex dynamic changes. Therefore, deep understanding underlying causes repeated specific antibacterial mechanisms at different stages is crucial effective "chronic management". This review first reveals relationship between chronicity, infections. Secondly, it focuses on four formation: (1) adhesion stage, (2) aggregation promotion (3) maturation (4) regeneration dissemination stage. It also comprehensively summarizes nanomaterials. study analyzes essential factors affecting control by nanoparticles from various perspectives, such material itself, local environment, systemic host response. Finally, limitations potential future trends current research discussed. summary, represent strategy combating infections, this provides new insights alternative adjuvant therapies managing

Language: Английский

Citations

2
Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers DOI

Xueqian Xiao,

Fei Zhao,

Davida Briana DuBois

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4195 - 4226

Published: May 16, 2024

Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, have become one of the most serious persistent complications diabetes mellitus because their high incidence difficulty in healing. Its malignancy results from a complex microenvironment that includes series unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, inflammation, ischemia hypoxia. However, current common clinical treatments, antibiotic therapy, insulin surgical debridement, conventional wound dressings all drawbacks, suboptimal outcomes exacerbate financial physical burdens patients. Therefore, development new, effective affordable treatments for DFU represents top priority improve quality life In recent years, nanozymes-based therapy systems been attracting extensive interest integrating unique advantages nanomaterials natural enzymes. Compared with enzymes, nanozymes possess more stable catalytic activity, lower production cost greater maneuverability. Remarkably, many multienzyme activities can cascade multiple enzyme-catalyzed reactions simultaneously throughout recovery process DFU. Additionally, favorable photothermal-acoustic properties be exploited further enhancement therapeutic effects. this review we first describe characteristic pathological DFU, then discuss mechanisms applications healing, finally, highlight challenges perspectives nanozyme treatment.

Language: Английский

Citations

0
Vesicle-like Nanocapsules Formed by Self-Assembly of Peptides with Oligoproline and -Leucine DOI

Yui Okamoto,

Masahiro Higuchi,

S. Matsubara

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(24), P. 12802 - 12809

Published: June 8, 2024

Since drug carriers are envisaged to be used in a wide variety of situations and environments, nanocarriers with diverse properties, such as biocompatibility, biodegradability, nonimmunogenicity, adequate particle size, robustness, cell permeability, required. Here, we report the construction novel nanocapsules above-mentioned features by self-assembly peptides composed oligoproline oligoleucine (i.e., H-Pro10Leu4-NH2 H-Pro10Leu6-NH2). The self-organized via hydrogen bonds hydrophobic interactions between moieties form vesicle-like cationic exposed on surface. guest encapsulation experiments revealed that were capable uptake both water-soluble insoluble compounds. Furthermore, positively charged and/or oligoproline-based known improve permeability cellular uptake, suggesting peptide good candidates for complement liposomes polymer micelles.

Language: Английский

Citations

0