Engineered Regeneration,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
Effective
antibacterial
property
and
long-term
mechanical
support
are
essential
for
the
repair
of
complex
abdominal
wall
defects
associated
with
infection.
However,
clinically
available
materials
often
fail
to
meet
these
requirements,
resulting
in
high
surgical
failure
rate
complications.
In
this
study,
an
asymmetric
porous
composite
hydrogel
patch
(cCS/PVA@BAC)
antibacterial,
anti-adhesion,
pro-healing,
durable
properties
is
designed
efficiently
contaminated
defects.
By
stepwise
phase-conversion
facile
immersion,
robust
stable
polyvinyl
alcohol
(PVAH)
integrated
biocompatible
comprising
chitosan
carboxymethyl
(cCS),
benzalkonium
chloride
(BAC)
loaded
enhance
property.
The
cCS
layer
cCS/PVA@BAC
has
extracellular
matrix-like
structure,
which
can
promote
fibroblasts
adhesion
wound
healing.
contrast,
PVAH
on
other
side
a
smooth
dense
reduce
prevent
visceral
adhesion.
addition,
good
anti-swelling
anti-deformation
as
well
strength,
thus
withstand
intraperitoneal
pressure
wet
internal
microenvironment.
BAC
kill
bacteria,
improve
local
inflammatory
With
advantages,
significantly
inflammation,
tissue
remodeling,
accelerate
healing
rat
model.
These
findings
suggest
potential
use
multifunctional
ideal
material
effective
soft
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Май 17, 2024
Abstract
Electronic
skin
(e‐skin),
a
skin‐like
wearable
electronic
device,
holds
great
promise
in
the
fields
of
telemedicine
and
personalized
healthcare
because
its
good
flexibility,
biocompatibility,
conformability,
sensing
performance.
E‐skin
can
monitor
various
health
indicators
human
body
real
time
over
long
term,
including
physical
(exercise,
respiration,
blood
pressure,
etc.)
chemical
(saliva,
sweat,
urine,
etc.).
In
recent
years,
development
materials,
analysis,
manufacturing
technologies
has
promoted
significant
e‐skin,
laying
foundation
for
application
next‐generation
medical
devices.
Herein,
properties
required
e‐skin
monitoring
devices
to
achieve
long‐term
precise
summarize
several
detectable
field
are
discussed.
Subsequently,
applications
integrated
systems
reviewed.
Finally,
current
challenges
future
directions
this
This
review
is
expected
generate
interest
inspiration
improvement
systems.
Biomacromolecules,
Год журнала:
2024,
Номер
25(8), С. 5359 - 5373
Опубликована: Июль 24, 2024
Inspired
by
the
animal
skin
fiber
network,
we
developed
an
electronic
(e-skin)
utilizing
natural
sheepskin
as
primary
substrate.
This
innovative
design
addresses
limitations
of
conventional
e-skins,
including
inadequate
mechanical
strength,
overly
complex
artificial
network
construction,
and
limited
health
monitoring
capabilities.
e-skin
successfully
retains
structure
properties
while
exhibiting
exceptional
strength
(with
a
breaking
4.01
MPa)
high
elongation
at
break
304.8%).
Moreover,
it
possesses
various
desirable
attributes
such
electrical
conductivity,
antibacterial
properties,
biocompatibility,
environmental
stability.
In
addition,
this
has
advantage
diverse
data
collection
(joint
movement,
bioelectricity,
foot
detection,
speech
disorder
communication
systems).
Therefore,
breaks
traditional
construction
strategy
single-mode
application
is
expected
to
become
ideal
material
for
building
smart
sensor
devices.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Март 18, 2024
Abstract
Biologically
inspired
peptide‐based
materials,
as
novel
charge
transport
have
gained
increasing
interest
in
bioelectronics
due
to
their
remarkable
electrical
properties
and
inherent
biocompatibility.
Extensive
studies
shown
that
peptides
can
self‐assemble
into
a
variety
of
hierarchical
nanostructures
with
unique
physical
through
supramolecular
interactions.
Therefore,
materials
hold
great
promise
for
applications
emerging
electronic
fields
such
sensing,
energy
harvesting,
storage,
transmission.
Herein,
this
work
proposes
review
article
summarize
the
rational
design
research
progress
devices
bioelectronics.
This
first
introduces
strategies
assembly
mechanism
constructing
high‐performance
devices.
In
following
part,
are
systematically
classified
discussed,
including
sensors,
piezoelectric
nanogenerators,
electrodes,
semiconductors.
Finally,
remaining
challenges
future
perspectives
bioelectronic
presented.
believes
will
provide
inspiration
guidance
development
innovative
smart
field
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(2), С. 2791 - 2813
Опубликована: Янв. 6, 2025
Transplantation
of
bone
implants
is
currently
recognized
as
one
the
most
effective
means
treating
defects.
Biobased
and
biodegradable
polyester
composites
combine
good
mechanical
degradable
properties
polyester,
thereby
providing
an
alternative
for
implant
materials.
Bone
tissue
engineering
(BTE)
accelerates
defect
repair
by
simulating
microenvironment.
Composite
scaffolds
support
formation
further
accelerate
process
repair.
The
introduction
3D
printing
technology
enables
preparation
to
be
more
precise,
reproducible,
flexible,
which
a
very
promising
development.
This
review
presents
physical
BTE
summarizes
strategies
adopted
domestic
international
scholars
improve
based
on
biobased
polyester/ceramic
in
recent
years.
In
addition,
future
development
prospects
field
challenges
expanding
production
clinical
applications
are
presented.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
This
study
explores
the
use
of
chicken
egg
white
(EW),
a
rich
source
natural
proteins,
to
address
challenges
in
wound
healing
management.
Herein,
novel
Zn2+-infused
EW/GelMA
(EW/Gel)
hybrid
hydrogel
is
developed,
featuring
an
interpenetrating
network
(IPN)
structure,
where
first
consists
photo-cross-linked
GelMA
and
second
EW
(Zn-EW)
through
ion–protein
binding.
By
optimizing
design
formulation,
resulting
Zn-EW/Gel
exhibited
enhanced
mechanical
stability
self-adhesive
properties.
In
vitro
experiments
demonstrated
that
combined
effects
functional
proteins
active
ions
within
promote
fibroblast
proliferation
type
I
collagen
expression,
modulate
immune
microenvironment,
enhance
angiogenesis.
The
also
excellent
biocompatibility
bioactivity
vivo,
showing
strong
promise
for
restoring
physiological
properties
damaged
tissue.
ABSTRACT
Recent
advancements
in
hydrogel‐based
flexible
materials
have
revolutionized
wound
healing
and
monitoring
strategies.
These
offer
promising
solutions
for
medical
treatment
real‐time
diagnostics.
Their
rich
water
content,
biocompatibility,
tunable
properties
closely
mimic
the
natural
extracellular
matrix,
supporting
regeneration.
Unlike
traditional
materials,
systems
address
critical
issues
such
as
material
stability
toxicity
while
integrating
advanced
devices.
This
review
highlights
latest
innovations
materials.
It
focuses
on
flexibility,
potential
integration
with
smart
systems.
The
covers
design
principles
fabrication
techniques
nanofibers,
elastomers,
conducting
polymers.
also
discusses
development
of
electronic
skin
innovative
dressings.
In
addition,
explains
how
sensing
capabilities,
stimuli‐responsive
functions,
antibacterial
agents
are
incorporated
into
these
Finally,
article
examines
challenges
future
directions
field.
emphasizes
transformative
multifunctional
improving
continuous
monitoring.
Nanomaterials,
Год журнала:
2024,
Номер
14(17), С. 1398 - 1398
Опубликована: Авг. 27, 2024
Electrophysiological
monitoring
is
a
commonly
used
medical
procedure
designed
to
capture
the
electrical
signals
generated
by
body
and
promptly
identify
any
abnormal
health
conditions.
Wearable
sensors
are
of
great
significance
in
signal
acquisition
for
electrophysiological
monitoring.
Traditional
devices
often
bulky
have
many
complex
accessories
thus,
only
suitable
limited
application
scenarios.
Hydrogels
optimized
based
on
nanomaterials
lightweight
with
excellent
stretchable
properties,
solving
problem
high-quality
wearable
sensors.
Therefore,
development
hydrogels
brings
tremendous
potential
physiological
This
review
first
introduces
latest
advancement
made
from
different
nanomaterials,
such
as
nanocarbon
materials,
nanometal
two-dimensional
transition
metal
compounds,
Second,
versatile
properties
these
composite
hydrogel
reviewed.
Then,
their
applications
various
monitoring,
electrocardiogram
electromyographic
analysis,
electroencephalogram
discussed.
Finally,
current
status
future
prospects
nanomaterial-optimized
summarized.
We
hope
this
will
inspire
using
nanomaterial-based
hydrogels.
Biomaterials Science,
Год журнала:
2024,
Номер
12(15), С. 3745 - 3764
Опубликована: Янв. 1, 2024
Hydrogels,
as
an
emerging
biomaterial,
have
found
extensive
use
in
the
healing
of
wounds
due
to
their
distinctive
physicochemical
structure
and
functional
properties.
Moreover,
hydrogels
can
be
made
match
a
range
therapeutic
requirements
for
materials
used
wound
through
specific
modifications.
This
review
provides
step-by-step
explanation
processes
involved
cutaneous
healing,
including
hemostasis,
inflammation,
proliferation,
reconstitution,
along
with
investigation
factors
that
impact
these
processes.
Furthermore,
thorough
analysis
is
conducted
on
various
stages
process
at
which
are
implemented,
anti-infection
measures,
encouraging
regeneration,
scar
reduction,
monitoring.
Next,
latest
progress
multifunctional
methods
achieve
functions
discussed
depth
categorized
elucidation.
Finally,
perspectives
challenges
associated
clinical
applications
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(32), С. 41869 - 41880
Опубликована: Авг. 5, 2024
Diabetic
wounds
that
do
not
heal
for
a
long
time
challenge
global
healthcare.
Mesenchymal
stem
cell
(MSC)
therapy
has
positive
significance
in
promoting
diabetic
wound
healing.
However,
traditional
MSC
involves
exogenous
MSCs,
which
brings
many
limitations
and
unsatisfactory
treatment.
Moreover,
the
maintenance
of
viability
function
is
difficult
because
high
level
reactive
oxygen
species
(ROS)
wounds.
Therefore,
we
developed
nanofibrous
dressing
to
recruit
protect
endogenous
MSCs
while
avoiding
inherent
disadvantages
MSCs.
Ceria
nanoparticles
capable
ROS
scavenging
are
integrated
into
dressings,
together
with
Apt19S,
DNA
aptamer
affinity
selectivity
In
addition,
homogenization
freeze-drying
technology
give
dressings
good
elasticity,
protects
from
external
pressure.
Further
experiments
mice
show
excellent
recruitment
anti-inflammatory
properties,
thereby
synergistically
This
study
expected
explore
an
efficient
method
therapy,
providing
new
way
construct
high-performance
dressings.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(40), С. 10346 - 10356
Опубликована: Янв. 1, 2024
Flexible
conductive
hydrogel-based
electronic
skin
(E-skin)
for
simultaneous
biotherapeutics
and
sensing
applications
is
one
of
the
current
research
directions.
In
this
study,
homogeneous
silk
fibroin/polyaniline/AgNP
complexes
(SPAg
complexes)
were
prepared
with
assistance
fibroin,
which
greatly
optimized
compatibility
PANI
hydrogel
matrix.
Then,
SPAg
was
introduced
into
covalently
crosslinked
polymer
network
to
prepare
poly(acrylamide-co-sulfobetaine
methacrylate)
-
hydrogels
(labeled
as
PSPAg
hydrogels).
The
exhibit
good
biocompatibility,
excellent
mechanical
properties,
superb
adhesive
performance,
fantastic
capabilities.
Being
connected
a
smartphone
via
Bluetooth
system,
E-skin
employed
accurately
monitor
human
movements
including
vigorous
joint
subtle
facial
micro-expressions.
Finally,
benefiting
from
synergistic
effect
antimicrobial
exogenous
electrical
stimulation,
through
promoting
angiogenesis
accelerating
collagen
production
in
diabetic
wounds,
successfully
facilitates
rapid
wound
healing.
Therefore,
multifunctional
shows
great
promise
wearable
devices
bioelectronics.
