Asymmetric porous composite hydrogel patch for microenvironment-adapted repair of contaminated abdominal wall defects DOI Creative Commons
Yang Yu,

Yinxiang Tang,

Weiwen Liang

и другие.

Engineered Regeneration, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Effective antibacterial property and long-term mechanical support are essential for the repair of complex abdominal wall defects associated with infection. However, clinically available materials often fail to meet these requirements, resulting in high surgical failure rate complications. In this study, an asymmetric porous composite hydrogel patch (cCS/PVA@BAC) antibacterial, anti-adhesion, pro-healing, durable properties is designed efficiently contaminated defects. By stepwise phase-conversion facile immersion, robust stable polyvinyl alcohol (PVAH) integrated biocompatible comprising chitosan carboxymethyl (cCS), benzalkonium chloride (BAC) loaded enhance property. The cCS layer cCS/PVA@BAC has extracellular matrix-like structure, which can promote fibroblasts adhesion wound healing. contrast, PVAH on other side a smooth dense reduce prevent visceral adhesion. addition, good anti-swelling anti-deformation as well strength, thus withstand intraperitoneal pressure wet internal microenvironment. BAC kill bacteria, improve local inflammatory With advantages, significantly inflammation, tissue remodeling, accelerate healing rat model. These findings suggest potential use multifunctional ideal material effective soft

Язык: Английский

Electronic Skin for Health Monitoring Systems: Properties, Functions, and Applications DOI

Xichen Yang,

Wenzheng Chen, Qunfu Fan

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 17, 2024

Abstract Electronic skin (e‐skin), a skin‐like wearable electronic device, holds great promise in the fields of telemedicine and personalized healthcare because its good flexibility, biocompatibility, conformability, sensing performance. E‐skin can monitor various health indicators human body real time over long term, including physical (exercise, respiration, blood pressure, etc.) chemical (saliva, sweat, urine, etc.). In recent years, development materials, analysis, manufacturing technologies has promoted significant e‐skin, laying foundation for application next‐generation medical devices. Herein, properties required e‐skin monitoring devices to achieve long‐term precise summarize several detectable field are discussed. Subsequently, applications integrated systems reviewed. Finally, current challenges future directions this This review is expected generate interest inspiration improvement systems.

Язык: Английский

Процитировано

43

Multifunctional, High-Strength Electronic Skin Based on the Natural Sheepskin Fiber Network for Multifaceted Human Health Monitoring and Management DOI
Yao Yang, Bin Song, Jinwei Zhang

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(8), С. 5359 - 5373

Опубликована: Июль 24, 2024

Inspired by the animal skin fiber network, we developed an electronic (e-skin) utilizing natural sheepskin as primary substrate. This innovative design addresses limitations of conventional e-skins, including inadequate mechanical strength, overly complex artificial network construction, and limited health monitoring capabilities. e-skin successfully retains structure properties while exhibiting exceptional strength (with a breaking 4.01 MPa) high elongation at break 304.8%). Moreover, it possesses various desirable attributes such electrical conductivity, antibacterial properties, biocompatibility, environmental stability. In addition, this has advantage diverse data collection (joint movement, bioelectricity, foot detection, speech disorder communication systems). Therefore, breaks traditional construction strategy single-mode application is expected to become ideal material for building smart sensor devices.

Язык: Английский

Процитировано

30

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications DOI

Jingwen Zhao,

Qingxi Liu,

Xiaoyu Tong

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(29)

Опубликована: Март 18, 2024

Abstract Biologically inspired peptide‐based materials, as novel charge transport have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical through supramolecular interactions. Therefore, materials hold great promise for applications emerging electronic fields such sensing, energy harvesting, storage, transmission. Herein, this work proposes review article summarize the rational design research progress devices bioelectronics. This first introduces strategies assembly mechanism constructing high‐performance devices. In following part, are systematically classified discussed, including sensors, piezoelectric nanogenerators, electrodes, semiconductors. Finally, remaining challenges future perspectives bioelectronic presented. believes will provide inspiration guidance development innovative smart field

Язык: Английский

Процитировано

17

Research Progress in 3D Printed Biobased and Biodegradable Polyester/Ceramic Composite Materials: Applications and Challenges in Bone Tissue Engineering DOI

Shunshun Zhu,

Hongnan Sun, Taihua Mu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 2791 - 2813

Опубликована: Янв. 6, 2025

Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.

Язык: Английский

Процитировано

2

Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing DOI
Qiujiang Li, Mengmeng Jin, Dan Sun

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

This study explores the use of chicken egg white (EW), a rich source natural proteins, to address challenges in wound healing management. Herein, novel Zn2+-infused EW/GelMA (EW/Gel) hybrid hydrogel is developed, featuring an interpenetrating network (IPN) structure, where first consists photo-cross-linked GelMA and second EW (Zn-EW) through ion–protein binding. By optimizing design formulation, resulting Zn-EW/Gel exhibited enhanced mechanical stability self-adhesive properties. In vitro experiments demonstrated that combined effects functional proteins active ions within promote fibroblast proliferation type I collagen expression, modulate immune microenvironment, enhance angiogenesis. The also excellent biocompatibility bioactivity vivo, showing strong promise for restoring physiological properties damaged tissue.

Язык: Английский

Процитировано

2

Hydrogel‐Based Smart Materials for Wound Healing and Sensing DOI Creative Commons
Thi Hoai Nhung Duong,

Thi Thuy Truong,

Thanh Van Phan

и другие.

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

ABSTRACT Recent advancements in hydrogel‐based flexible materials have revolutionized wound healing and monitoring strategies. These offer promising solutions for medical treatment real‐time diagnostics. Their rich water content, biocompatibility, tunable properties closely mimic the natural extracellular matrix, supporting regeneration. Unlike traditional materials, systems address critical issues such as material stability toxicity while integrating advanced devices. This review highlights latest innovations materials. It focuses on flexibility, potential integration with smart systems. The covers design principles fabrication techniques nanofibers, elastomers, conducting polymers. also discusses development of electronic skin innovative dressings. In addition, explains how sensing capabilities, stimuli‐responsive functions, antibacterial agents are incorporated into these Finally, article examines challenges future directions field. emphasizes transformative multifunctional improving continuous monitoring.

Язык: Английский

Процитировано

1

Recent Advances of Stretchable Nanomaterial-Based Hydrogels for Wearable Sensors and Electrophysiological Signals Monitoring DOI Creative Commons

Haiyang Duan,

Yilong Zhang, Yitao Zhang

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(17), С. 1398 - 1398

Опубликована: Авг. 27, 2024

Electrophysiological monitoring is a commonly used medical procedure designed to capture the electrical signals generated by body and promptly identify any abnormal health conditions. Wearable sensors are of great significance in signal acquisition for electrophysiological monitoring. Traditional devices often bulky have many complex accessories thus, only suitable limited application scenarios. Hydrogels optimized based on nanomaterials lightweight with excellent stretchable properties, solving problem high-quality wearable sensors. Therefore, development hydrogels brings tremendous potential physiological This review first introduces latest advancement made from different nanomaterials, such as nanocarbon materials, nanometal two-dimensional transition metal compounds, Second, versatile properties these composite hydrogel reviewed. Then, their applications various monitoring, electrocardiogram electromyographic analysis, electroencephalogram discussed. Finally, current status future prospects nanomaterial-optimized summarized. We hope this will inspire using nanomaterial-based hydrogels.

Язык: Английский

Процитировано

6

A comprehensive exploration of hydrogel applications in multi-stage skin wound healing DOI
Yongping Lu, Yuemin Wang, Jie Wang

и другие.

Biomaterials Science, Год журнала: 2024, Номер 12(15), С. 3745 - 3764

Опубликована: Янв. 1, 2024

Hydrogels, as an emerging biomaterial, have found extensive use in the healing of wounds due to their distinctive physicochemical structure and functional properties. Moreover, hydrogels can be made match a range therapeutic requirements for materials used wound through specific modifications. This review provides step-by-step explanation processes involved cutaneous healing, including hemostasis, inflammation, proliferation, reconstitution, along with investigation factors that impact these processes. Furthermore, thorough analysis is conducted on various stages process at which are implemented, anti-infection measures, encouraging regeneration, scar reduction, monitoring. Next, latest progress multifunctional methods achieve functions discussed depth categorized elucidation. Finally, perspectives challenges associated clinical applications discussed.

Язык: Английский

Процитировано

5

Elastic Nanofibrous Dressings with Mesenchymal Stem Cell-Recruiting and Protecting Characteristics for Promoting Diabetic Wound Healing DOI
Kexin Zhang, Chenyu Zhang,

Huanxin Zhou

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(32), С. 41869 - 41880

Опубликована: Авг. 5, 2024

Diabetic wounds that do not heal for a long time challenge global healthcare. Mesenchymal stem cell (MSC) therapy has positive significance in promoting diabetic wound healing. However, traditional MSC involves exogenous MSCs, which brings many limitations and unsatisfactory treatment. Moreover, the maintenance of viability function is difficult because high level reactive oxygen species (ROS) wounds. Therefore, we developed nanofibrous dressing to recruit protect endogenous MSCs while avoiding inherent disadvantages MSCs. Ceria nanoparticles capable ROS scavenging are integrated into dressings, together with Apt19S, DNA aptamer affinity selectivity In addition, homogenization freeze-drying technology give dressings good elasticity, protects from external pressure. Further experiments mice show excellent recruitment anti-inflammatory properties, thereby synergistically This study expected explore an efficient method therapy, providing new way construct high-performance dressings.

Язык: Английский

Процитировано

5

Flexible and antibacterial conductive hydrogels based on silk fibroin/polyaniline/AgNPs for motion sensing and wound healing promotion under electrical stimulation DOI
Ruiqi Liu, Siwei Bi,

Linna Zhang

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(40), С. 10346 - 10356

Опубликована: Янв. 1, 2024

Flexible conductive hydrogel-based electronic skin (E-skin) for simultaneous biotherapeutics and sensing applications is one of the current research directions. In this study, homogeneous silk fibroin/polyaniline/AgNP complexes (SPAg complexes) were prepared with assistance fibroin, which greatly optimized compatibility PANI hydrogel matrix. Then, SPAg was introduced into covalently crosslinked polymer network to prepare poly(acrylamide-co-sulfobetaine methacrylate) - hydrogels (labeled as PSPAg hydrogels). The exhibit good biocompatibility, excellent mechanical properties, superb adhesive performance, fantastic capabilities. Being connected a smartphone via Bluetooth system, E-skin employed accurately monitor human movements including vigorous joint subtle facial micro-expressions. Finally, benefiting from synergistic effect antimicrobial exogenous electrical stimulation, through promoting angiogenesis accelerating collagen production in diabetic wounds, successfully facilitates rapid wound healing. Therefore, multifunctional shows great promise wearable devices bioelectronics.

Язык: Английский

Процитировано

5