Enhancing vaccine stability in transdermal microneedle platforms

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

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Novel nanomaterials-based combating strategies against drug-resistant bacteria

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 248, С. 114478 - 114478

Опубликована: Дек. 28, 2024

Язык: Английский

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Gold nanorods coated by self-assembled silk fibroin for improving their biocompatibility and facilitating targeted photothermal-photodynamic cancer therapy

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Gold nanorods (AuNRs) have shown great potential as photothermal agents for cancer therapy. However, the biosafety of AuNRs ordinarily synthesized using a cationic ligand assistance procedure has always been subject controversy, which limits their application in tumor In this study, we propose novel strategy to enhance biocompatibility by constructing biological coating derived from silk fibroin (SF) on surface. The SF could be easily and precisely manipulated layer-by-layer (LBL) assembly method. resulting SF-coated gold (AuNRs@SF) exhibited reduced cytotoxicity improved hemocompatibility compared untreated AuNRs. Moreover, treated were modified with tumor-targeting peptide (AuNRs@MTSF) efficiently loaded indocyanine green (ICG). Both vitro vivo analyses demonstrated that AuNRs@MTSF more effectively reach tissue enter MCF-7 cells. Furthermore, after loading ICG, superior antitumor efficacy other groups combining photodynamic therapy (PDT) (PTT) under near-infrared (NIR) irradiation without inducing any side effects. This work suggests is approach improving biocompatibility, function-modified AuNRs@SF are effective nanoplatforms targeted multimodal

Язык: Английский

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Left out in the cold - inequity in infectious disease control due to cold chain disparity

Vaccine, Год журнала: 2024, Номер 45, С. 126648 - 126648

Опубликована: Дек. 20, 2024

Язык: Английский

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