Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180

Опубликована: Авг. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Язык: Английский

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Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Bioactive Materials, Год журнала: 2024, Номер 38, С. 292 - 304

Опубликована: Май 8, 2024

Delays in infected wound healing are usually a result of bacterial infection and local inflammation, which imposes significant often underappreciated burden on patients society. Current therapies for chronic generally suffer from limited drug permeability frequent administration, owing to the existence biofilm that acts as barrier restricting entry various antibacterial drugs. Here, we report design biocompatible probiotic-based microneedle (MN) patch can rapidly deliver beneficial bacteria tissues with improved delivery efficiency. The probiotic is capable continuously producing antimicrobial substances by metabolizing introduced glycerol, thereby facilitating through long-acting anti-inflammatory effects. Additionally, remain highly viable (>80 %) inside MNs long 60 days at 4 °C. In mouse model Staphylococcus aureus-infected wounds, single administration MN exhibited superior efficiency performance comparison control groups, indicating great potential accelerating closure. Further development live patches may enable better manage chronically wounds.

Язык: Английский

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Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics

Gels, Год журнала: 2025, Номер 11(3), С. 206 - 206

Опубликована: Март 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Язык: Английский

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Swellable Microneedles in Drug Delivery and Diagnostics

Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 791 - 791

Опубликована: Июнь 16, 2024

This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs medical treatment monitoring. Innovations hydrogel-integrated MN arrays facilitate controlled release, thereby expanding options for chronic diseases conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, manufacturing processes, well achievements advanced manufacturing, biocompatibility, versatile applications. Nonetheless, limitations physiological responsiveness long-term stability remain, necessitating further research material innovation integration with digital technologies. Future directions focus on biomedical applications, advancements, regulatory considerations widespread clinical adoption.

Язык: Английский

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Microneedle hierarchical structure construction for promoting multi-stage wound healing

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125474 - 125474

Опубликована: Март 1, 2025

Язык: Английский

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Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(51), С. 70339 - 70351

Опубликована: Дек. 13, 2024

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating treatment infections caused by pathogens such bacteria, fungi, viruses through topical methods. In this research, microneedle patch was developed, which consists gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served primary substrate shaft (PDA@Cu-SG/PEGDA). This engineered to enhance permeability facilitate efficient delivery drugs rapid dissolution tips. Coordinate bonds can be formed between PDA Cu ions, resulting in immobilization particles on surface, aids green synthesis PDA@Cu photothermal particles. SG polymer, contained PDA@Cu, employed fill cavities series centrifugation steps. Subsequently, UV-induced polymerization carried out produce PEGDA microneedles with hydrophilic tips Furthermore, physicochemical characteristics polymer microneedles, including morphology, composition, mechanical strength, were thoroughly characterized. These demonstrated sufficient strength. Owing ability disrupt bacterial membranes, excellent vitro efficacy. We validated activity against Escherichia coli Staphylococcus aureus conducting plate coating assays. results assays indicated minimally invasive strategy achieved broad-spectrum effects; thus, may suitable approach managing polymicrobial during clinical trials.

Язык: Английский

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α-Amylase and polydopamine@polypyrrole-based hydrogel microneedles promote wound healing by eliminating bacterial infection

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136604 - 136604

Опубликована: Окт. 1, 2024

Язык: Английский

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