Green engineered biomaterials for bone repair and regeneration: Printing technologies and fracture analysis

Chemical Engineering Journal, Год журнала: 2024, Номер 494, С. 152703 - 152703

Опубликована: Июнь 5, 2024

Язык: Английский

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Flexible Short Silica Fibers and Tricalcium Phosphate Synergistically Promote Bone Fracture Healing in Composite Cryogel Scaffolds

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Bone tissue engineering is a critical area of research focused on enhancing the regeneration bone tissue, particularly in cases complex defects. Despite inherent self-healing capabilities bone, irregularly-shaped defects pose significant challenges for complete regeneration, thereby necessitating innovative therapeutic strategies. This study addresses these by exploring development advanced scaffolds. Here, tricalcium phosphate (TCP) integrated with short silica (SiO2) fibers to develop 3D cryogel scaffolds, designated as SSFx@TCP. These scaffolds exhibit low density (<2 mg cm- 3), high water absorption (>3500%), and favorable sustained release properties, enabling effective cellular interactions. Notably, SSFx@TCP cryogels support cell attachment, proliferation, differentiation, while also regulate gene expression associated angiogenesis osteogenesis. Furthermore, vivo assays demonstrated that can effectively promote de novo production rat calvarial defect model 8 weeks post-operatively, indicating their potential mimic natural extracellular matrix. The successful integration bioactive components may be beneficial improved clinical outcomes therapies ultimately patient care reconstructive surgery.

Язык: Английский

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Biomimetic Structural Design in 3D-Printed Scaffolds for Bone Tissue Engineering

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101664 - 101664

Опубликована: Март 14, 2025

Язык: Английский

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Applications and Progress of 3D Printed Bioceramic Scaffolds in Bone Tissue Repair and Immune Regulation

Ceramics International, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Bone augmentation of maxillary sinus floor elevation with hydroxyapatite/ poly(lactide-co-caprolactone) composites

Materials Today Nano, Год журнала: 2025, Номер unknown, С. 100624 - 100624

Опубликована: Апрель 1, 2025

Язык: Английский

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Dual Nano-Reinforced 3D-Printed Polylactic Acid Scaffolds for Antibacterial and Osteogenic Applications

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Язык: Английский

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A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies

PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0323754 - e0323754

Опубликована: Май 19, 2025

Regeneration of maxillofacial bone structures is challenging. One strategy for damage repair involves using filler particles. This study analyzed the regenerative potential deproteinized particles (DP) and collagen-based (CP) to determine effectiveness each biomaterial in repair. Structural analysis scanning electron microscopy 3D showed that DP CP were structurally similar, comprising a heterogeneous mixture varying sizes shapes. Ex vivo analyses, including morphological evaluation, LIVE & DEAD assays, DNA quantification, demonstrated high biocompatibility with human cells both direct indirect contact at 24, 48, 72 hours. Both grafted onto Wistar rats critical mandibular defect two months. Computed tomography revealed significant reduction group, but not compared negative controls without any Histological identified tissue collagen fibers mineralized spots DP, more DP. Histochemistry immunohistochemistry confirmed collagen, proteoglycans, osteocalcin presence regeneration area These results confirm particle types regeneration, particularly CP. Future studies should assess their clinical usefulness patients cleft palate, damage, other applications involving engineering techniques.

Язык: Английский

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A Sr@Ag-based spatiotemporal and step-release scaffold against chronic osteomyelitis, fabricated by coaxial 3D-printing

Biomaterials, Год журнала: 2024, Номер 314, С. 122899 - 122899

Опубликована: Окт. 18, 2024

Язык: Английский

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Nanosheet-assembled porous-wall hollow hydroxyapatite microspheres prepared by a template-free hydrothermal method for pH-responsive drug release

Ceramics International, Год журнала: 2024, Номер 50(22), С. 47501 - 47506

Опубликована: Сен. 3, 2024

Язык: Английский

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