Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 283 - 283
Опубликована: Фев. 20, 2025
Psoriasis
is
a
chronic
inflammatory
disease
with
complex
pathogenesis,
influenced
by
various
factors
involving
environment,
genes,
and
immunity.
The
main
symptoms
of
psoriasis
include
erythema,
scales,
itching,
etc.
At
present,
therapeutic
drugs
for
are
continually
evolving
towards
enhancing
treatment
efficacy
reducing
side
effects.
Firstly,
the
pathogenesis
characteristics
were
summarized.
Then,
types
benefits
topical
therapy
introduced,
such
as
aspects
avoiding
systemic
toxic
effects,
first
pass
effect,
gastrointestinal
reactions
accelerating
onset
time
improving
its
efficacy,
compared
to
drugs.
In
case
methotrexate,
cyclosporin
A,
Janus
kinase
(JAK)
inhibitors,
phosphodiesterase-4
(PDE-4)
this
review
had
further
discussion
on
improvement
translation
these
molecules
from
in
clinical
practice.
To
augment
limitation
skin
permeability,
nanotechnology
novel
drug
delivery
system
including
nanomedicines,
hydrogels,
ionic
liquids,
microneedles
elaborated
management.
Also,
exploration
targeting
pathogenic
genes
through
small
interfering
RNA
(siRNA)
using
nanoparticles
liquids
(ILs)
great
significance
long-term
psoriasis.
Taken
together,
development
numerous
platforms
expected
achieve
enhanced
penetration,
precise
efficient
molecule
interference
(RNAi)
therapeutics
prospects.
Язык: Английский
Emerging Therapeutic Agents and Nanotechnology-Driven Innovations in Psoriasis Management
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(3)
Опубликована: Март 19, 2025
Psoriasis
has
been
a
rising
concern
for
over
decade,
imposing
significant
challenges
to
individuals
and
society.
Traditional
topical
therapy
is
non-targeted
acts
systemically,
with
associated
side
effects.
This
increases
the
global
burden
both
socially
economically.
review
covers
evolution
of
drug
molecules
nanotechnology-based
approaches
treatment
psoriasis,
chronic
inflammatory
skin
disorder
no
known
etiology.
Nanotechnology-based
offer
promising
solutions
by
reducing
effects,
providing
targeted
delivery,
protecting
from
degradation,
enhancing
retention,
controlled
release.
Researchers
have
investigated
incorporation
various
conventional
non-conventional
therapeutic
agents
into
nanocarriers
psoriasis
treatment.
The
current
understanding
disease
its
using
combined
novel
formulation
strategies
will
reduce
duration
improve
quality
life
in
psoriatic
conditions.
Язык: Английский
The H2S-releasing multifunctional composite ionic liquid facilitates topical melittin delivery for psoriasis treatment through RONS scavenging and inflammation inhibition
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160972 - 160972
Опубликована: Фев. 1, 2025
Язык: Английский
Ionic liquids as transdermal drug carriers: A review of recent advancements
Journal of Molecular Liquids,
Год журнала:
2025,
Номер
unknown, С. 127595 - 127595
Опубликована: Апрель 1, 2025
Improved topical delivery of curcumin by hydrogels formed by composite carriers integrated with cyclodextrin metal-organic frameworks and cyclodextrin nanosponges
Songting Li,
Long Meng,
Jiaqi Li
и другие.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100310 - 100310
Опубликована: Дек. 1, 2024
Curcumin
(CUR)
is
highly
promising
for
topical
therapeutic
applications,
but
water-insolubility
one
of
the
major
challenges
plaguing
its
drugability,
while
conventional
lipid
nanocarriers
are
limited
by
low
drug-carrying
capacity,
many
additives,
and
complex
processes.
In
current
work,
we
constructed
a
composite
carrier
integrated
with
cyclodextrin
metal-organic
framework
(γ-CD-MOF)
nanosponge
(β-CDNS),
in
which
γ-CD-MOF
had
13.9
%
drug
loading
267.1-fold
increase
solubility
water
CUR,
β-CDNS
showed
bioadhesion
further
increasing
solubility.
The
(γ-CD-MOF@β-CDNS)
significantly
improved
vitro
release
transdermal
permeation
absorption
properties
excellent
create
an
advantage
local
administration
treating
diseases
high
exudate,
prevents
affected
area
from
deteriorating
condition
counter-absorption
formulation.
Thus,
this
contributes
new
option
to
address
delivery
insoluble
drugs
offers
strategy
clinical
application
CUR.
Язык: Английский
Exploring the World of Curcumin: Photophysics, Photochemistry, and Applications in Nanoscience and Biology
ChemBioChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
Abstract
Curcumin
is
a
bright
yellow
naturally
occurring
polyphenol
which
the
principal
component
of
turmeric.
It
used
as
herbal
supplement,
cosmetics
ingredient,
and
food
coloring
agent.
Over
years,
therapeutic
properties
natural
product
curcumin
have
gone
unexploited
but
not
unnoticed.
cannot
be
employed
drug
due
to
limitations
such
low
aqueous
solubility
limited
bioavailability.
Many
attempts
been
made
overcome
these
by
confining
in
various
confined
media
enhance
its
The
biomolecule
emissive
undergoes
fundamental
excited
state
processes
solvation
dynamics
intramolecular
proton
transfer
(ESIPT).
based
biomaterials
nanomaterials
are
also
fast
advancing
field
where
an
intrinsic
necessary
for
formation
materials
no
longer
added
external
free
drug.
In
this
review,
we
will
summarize
recent
research
on
photophysical
photochemical
bio‐mimicking
systems.
At
same
time
wish
incorporate
applications
curcumin,
especially
biology.
Lastly
growing
importance
science,
briefly
discuss
some
advances
nanomaterials.
We
believe
compilation
surrounding
provide
overall
understanding
potentialities
different
areas.
Язык: Английский