JUSTC, Год журнала: 2024, Номер 54, С. 1 - 1
Опубликована: Янв. 1, 2024
Язык: Английский
ACS Materials Letters, Год журнала: 2024, Номер 6(10), С. 4791 - 4800
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
8
Theranostics, Год журнала: 2025, Номер 15(8), С. 3490 - 3516
Опубликована: Фев. 24, 2025
Rationale: Dental implant restoration is essential for rehabilitating dentition defects. However, peri-implantitis (PI) seriously threatens the long-term stability of implants. Treating PI requires complete eradication plaque biofilm and meticulous modulation inflammatory responses. Antibacterial photodynamic therapy (aPDT) presents a promising potential in antibacterial realm. Nonetheless, traditional aPDT faces challenges such as inadequate penetration distribution photosensitizers, well lack precise bacteria targeting. Moreover, excessive ROS generated by will aggravate oxidative stress peri-implant tissues, this issue cannot be neglected. Methods: The CuTA-Por@ε-PL nanoplatforms (CPP NPs) were synthesized characterized using dynamic light scattering, transmission electron microscopy, dye probes detail. anti-inflammatory activities CPP NPs evaluated both vitro vivo. vivo therapeutic efficacy was successively analyzed through micro-CT, hematoxylin eosin staining, Masson's immunofluorescence colony formation units (CFU), among other techniques. Results: Porphyrin (Por), CuTA nanozyme with SOD/CAT activities, ε-Polylysine (ε-PL) combined to fabricate via straightforward approach. notable positive charge facilitated penetration, Then, irradiation 660 nm laser triggered burst elimination. After aPDT, scavenged residual modulated host immunity regulating macrophage polarization. As result, CPP-treated groups demonstrated most outstanding performance rat model. Conclusions: Given pathogenesis PI, strategy rationally designed multifunctional NP functions spatiotemporal regulation. It provides potentially novel approach treatment, which may have profound impact on improving prognosis patients advancing field dentistry.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Radioresistance in tumors and the excess damage normal tissues during radiotherapy (RT) restrict clinical application of glioblastoma RT. Image-guided radiosensitization is hopefully adopted to achieve precision Nevertheless, therapeutic effect radiosensitizers unsatisfactory due limitations blood–brain barrier poor tumor targeting. Herein, Fe3O4@Bi2S3 nanoparticles coated with a cell membrane (denoted as FBM) have been designed sensitize FBM accumulates precisely within via external magnetism homologous adhesion capability. Afterward, releases high-Z atoms (Bismuth) ionizing radiation micro acidic environments that interact generate high densities secondary radiation, which leads enhanced dose deposits. Simultaneously, generates reactive oxygen species, lipid peroxidation Fe2+, depletes glutathione, downregulates glutathione peroxidase 4 activate ferroptosis. Notably, growth inhibition rate FBM-mediated RT increases 75.49% orthotopic model. Besides, magnetic resonance imaging performance shows potential diagnosis therapy surveillance, thereby reducing adjacent realizing MRI-guided Hence, novel multifunctional nanoplatform offers for image-guided induced by activating ferroptosis, thus presenting an efficient radiotherapeutic approach glioblastoma.
Язык: Английский
Процитировано
0
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100781 - 100781
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Сен. 19, 2024
Sonodynamic therapy (SDT) can generate reactive oxygen species (ROS) to combat multidrug-resistant biofilms, which pose significant challenges human health. As the key producing ROS in SDT, design of sonosensitizers with optimal molecular structures for sufficient generation and activity complex biofilm matrix is essential. In this study, we propose a π-expansion strategy synthesize series small-molecule metal Ru(II) complexes (
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 31, 2024
Mild hyperthermia therapy has garnered interest as an adjunctive treatment for bone repair. However, its optimal timing, duration, and underlying mechanisms remain unclear. In this study, how mild supports repair during the early stages is assesed. These findings reveal that accelerates regeneration by dynamically regulating inducible nitric oxide synthase/arginase 1 (iNOS/Arg1) balance. This process involves macrophage polarization to M1 phenotype through iNOS activation, followed a rapid transition M2 Arg1 activation after 3 days of sustained hyperthermia. RNA-Seq reveals single day induced immune alterations aligned with inflammatory phase repair, characterized osteoclast cell recruitment, neovascularization, thereby preparing phase. Experiments involving subcutaneous abscesses, embedding, critical cranial defects further confirm regulates phenotypes. regulation enhances antibacterial activity, promotes angiogenesis, facilitates from inflammation ultimately accelerating bone-defect study first elucidate dual temporal effects on regulation, offering insights into timing duration photothermal following surgery.
Язык: Английский
Процитировано
2
Colloids and Interfaces, Год журнала: 2024, Номер 8(3), С. 28 - 28
Опубликована: Апрель 30, 2024
Bi2S3 has gained considerable attention as a semiconductor for its versatile functional properties, finding application across various fields, and liquid phase exfoliation (LPE) serves straightforward method to produce it in nano-form. Till now, the commonly used solvent LPE been N-Methyl-2-pyrrolidone, which is expensive, toxic high boiling point. These limitations drive search more sustainable alternatives, with water being promising option. Nonetheless, surfactants are necessary due hydrophobic nature of Bi2S3, organic molecules amphoteric characteristics identified suitable surfactants. However, systematic studies on use ionic have remained scarce until now. In this work, we sodium dodecyl sulfate (SDS), dodecylbenzene sulfonate (SDBS) hexadecyl (SHS) representative species present comprehensive investigation into their effects Bi2S3. Through characterizations resulting products, find that all effectively exfoliate few-layer species. Notably, SDBS demonstrates superior stabilization 2D layers compared other surfactants, while SHS becomes most surfactant obtaining products yield. Moreover, nano-inks fabricating films using spray-coating, reaching fine tuning band gap by controlling number cycles, paving way utilization optoelectronic devices.
Язык: Английский
Процитировано
1
Small, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 22, 2024
The rise of antibiotic resistance poses a critical threat to global health, necessitating the development novel antibacterial strategies mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as promising solution in context. These mimicking entities such plants, animals, cells, viruses, and enzymes, offer innovative approaches combat bacterial infections effectively. This review delves into integration biomimicry with materials science develop agents that are not only effective but also biocompatible less likely induce resistance. study explores design function various biomimetic highlighting their therapeutic potential anti-infection applications. Further, provides comprehensive summary recent advancements field, illustrating how these been engineered enhance efficacy safety. discusses challenges facing transition from laboratory clinical settings, scalability, cost-effectiveness, long-term stability. Lastly, vast opportunities hold for future therapy, suggesting continued research multidisciplinary collaboration will be essential realize full potential.
Язык: Английский
Процитировано
1
Korean Journal of Dental Materials, Год журнала: 2024, Номер 51(3), С. 129 - 144
Опубликована: Сен. 30, 2024
본 연구는 티타늄(Ti) 임플란트에서 몰리브덴 이황화물(MoS₂) 코팅의 접착력, 표면특성 및 부식 저항성을 향상시키기 위해 중간층으로서 폴리도파민(PDA)의 역할을 조사하였다. 이를 Ti 표면에 PDA 처리를 한 후 MoS2 코팅을 샘플과 Ti에 직접 MoS₂ 샘플을 비교 분석하였다. 표면 특성 분석은 X선 회절(XRD), 광전자 분광법(XPS), 라만 분광법 주사 전자 현미경(SEM)을 사용하여 종합적으로 수행되었다. SEM 분석 결과에 따르면, 층은 더 균일하고 미세한 구조의 촉진하는 것으로 나타났다. 습윤성 테스트에서는 MoS₂-PDA 처리된 표면이 코팅된 표면보다 향상된 친수성을 보였다. 전위 동적 분극을 이용한 저항성 테스트 결과, 샘플이 샘플보다 낮은 전류 밀도와 높은 전위를 나타냈다. 세포 생존율 분석에서는 표면과 모두 유사한 생체적합성을 보였으나, 적합성에서는 군이 약간 결과를 이러한 결과는 중간층이 구조적 특성을 향상시키는 반면, 두 접근법 간의 생체적합성 차이에 대한 많은 연구가 필요함을 시사한다. 중간층은 여전히 특성과 데 있어 정형외과 응용에서 잠재력을 보이고 있다.
Процитировано
0