Application of nanomaterials in precision treatment of lung cancer DOI Creative Commons
Chengcheng Zhang, Jiang Fan,

Liang Wu

и другие.

iScience, Год журнала: 2024, Номер 28(1), С. 111704 - 111704

Опубликована: Дек. 27, 2024

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by high mortality rates due to its aggressive nature, metastatic potential, drug resistance. Despite advancements in conventional therapies, their efficacy is often limited systemic toxicity, poor tumor specificity, emergence resistance mechanisms. Nanomedicine has emerged as a promising approach address these challenges, leveraging unique physicochemical properties nanomaterials enhance delivery, reduce off-target effects, enable combination therapies. This review provides comprehensive overview applications lung treatment, focusing on chemotherapy, phototherapy, immunotherapy. Key strategies include development stimuli-responsive nanoparticles, active targeting mechanisms, multifunctional platforms for co-delivery therapeutic agents. Notable successes, such liposomal formulations polymeric highlight potential overcome biological barriers improve outcomes. However, significant challenges remain, including penetration, immunogenicity, scalability manufacturing, regulatory complexities. Addressing limitations through innovative design, advanced manufacturing technologies, interdisciplinary collaboration will be critical translating nanomedicine from bench bedside. Overall, represents transformative frontier therapy, offering patient outcomes quality life.

Язык: Английский

Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies DOI Creative Commons

Melanie Bresinskya,

Achim Goepfericha

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер unknown, С. 114634 - 114634

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma DOI
Muhammad Ismail,

Yibin Wang,

Y. M. Li

и другие.

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the modalities of GBM. At beginning review, we highlighted stimuli-active polymeric carrying therapies that potentially boost anti-GBM responses employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these target ligands further enhanced their capacity to traverse blood-brain barrier (BBB) preferentially accumulate in glioma cells. These unique features lead more effective cancer minimal adverse reactions superior therapeutic outcomes. Finally, review summarizes existing difficulties future prospects treating Overall, this offers theoretical guidelines developing intelligent versatile facilitate precise GBM clinical settings.

Язык: Английский

Процитировано

8
Carbohydrate polymer-functionalized metal nanoparticles in cancer therapy: A review DOI
Xi Zhou, Dongbin Zhang, Mingming Han

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141235 - 141235

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

0
Self-Assembled Ferritin Nanoparticles for Delivery of Antigens and Development of Vaccines: From Structure and Property to Applications DOI Creative Commons
Shinuo Cao, Dongxue Ma, Shengwei Ji

и другие.

Molecules, Год журнала: 2024, Номер 29(17), С. 4221 - 4221

Опубликована: Сен. 5, 2024

Ferritin, an iron storage protein, is ubiquitously distributed across diverse life forms, fulfilling crucial roles encompassing retention, conversion, orchestration of cellular metabolism, and safeguarding cells against oxidative harm. Noteworthy attributes ferritin include its innate amenability to facile modification, scalable mass production, as well exceptional stability safety. In addition, boasts unique physicochemical properties, including pH responsiveness, resilience elevated temperatures, resistance a myriad denaturing agents. Therefore, serves the substrate for creating nanomaterials typified by uniform particle dimensions biocompatibility. Comprising 24 subunits, each nanocage demonstrates self-assembly capabilities, culminating in formation nanostructures akin intricate cages. Recent years have witnessed ascendance ferritin-based self-assembled nanoparticles, owing their distinctive traits, which confer substantial advantages wide-ranging applications within biomedical domain. Ferritin highly appealing carrier delivering drug molecules antigen proteins due structural biochemical properties. This review aims highlight recent advances use novel delivery vaccine development, discussing molecular mechanisms underlying action, presenting it promising effective strategy future development.

Язык: Английский

Процитировано

3
Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer DOI Creative Commons

Ryunosuke Hoshi,

Kristyna A. Gorospe,

Hagar I. Labouta

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1181 - 1181

Опубликована: Сен. 7, 2024

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint constitutes an inhibitory pathway best known for its regulation of cluster differentiation 8 (CD8)+ T cell-mediated responses. Engagement PD-L1 with PD-1 expressed on CD8+ cells activates downstream signaling pathways that culminate in cell exhaustion and/or apoptosis. Physiologically, these immunosuppressive effects exist to prevent autoimmunity, but cancer exploit this by overexpressing facilitate escape. Intravenously (IV) administered inhibitors (ICIs) block the interaction between PD-1/PD-L1 have achieved great success reversing and promoting tumor regression various malignancies. However, ICIs can cause immune-related adverse events (irAEs) due off-tumor toxicities which limits their therapeutic potential. Therefore, considerable effort has been channeled into exploring alternative delivery strategies enhance tumor-directed reduce irAEs. Here, we briefly describe PD-1/PD-L1-targeted immunotherapy associated We then provide a detailed review approaches, including locoregional (LDD)-, oncolytic virus (OV)-, nanoparticle (NP)-, ultrasound microbubble (USMB)-mediated are currently under investigation enhancing tumor-specific minimize toxic effects. conclude commentary key challenges methods potential mitigate them.

Язык: Английский

Процитировано

2
pH-Responsive Rhodamine Nanotube Capable of Self-Reporting the Assembly State DOI

Ziyuan Meng,

Sagarika Taneja,

Reham A. Hassan

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 47089 - 47099

Опубликована: Авг. 28, 2024

Nanomaterials that respond to intracellular signals, such as pH, have the potential for many biomedical applications, drug delivery, because assembly/disassembly process can be tailored a stimulus characteristic of specific subcellular location. In this work, two rhodamine-peptides form stable nanotubes at physiological pH but dissociate into highly fluorescent monomers within acidified interior endosomal/lysosomal cellular compartments been developed. The rhodamine dipeptide conjugates, NH2-KK(RhB)-NH2 (RhB-KK) and NH2-EK(RhB)-NH2 (RhB-KE) with B chromophores appended ε-amino position lysine residue, were shown assemble well-defined values above ∼4–5 monomer state lower values. dependence assembly was investigated using circular dichroism (CD) fluorescence spectroscopy along transmission electron microscopy (TEM), atomic force (AFM), confocal imaging. Although ring opening/closing transition chromophore took place 4.1 both peptides, onset began 4.6 RhB-KE comparatively more basic (5.8) RhB-KK. Accordingly, interconverted between three pH-dependent states: an open-ring, monomeric (λmax 580 nm, λex 550 nm) or below ∼4.6; closed-ring, nanotube exhibits AIEE 460 = 330 higher values; nonemissive emerged critical micelle concentrations (CMC). pH-responsive features peptides evaluated by live-cell imaging in cancer cell lines laser scanning (CLSM). Visualizing cells after incubation either RhB-KK produced CLSM images punctate appearance Texas Red channel colocalized lysosomes. These experiments indicate rapidly trafficked acidic lysosomal cells, which induced dissociation monomeric, open state. Uptake inhibition studies suggested uptake mediated caveolae- clathrin-mediated endocytosis, depending on line studied.

Язык: Английский

Процитировано

0
Application of nanomaterials in precision treatment of lung cancer DOI Creative Commons
Chengcheng Zhang, Jiang Fan,

Liang Wu

и другие.

iScience, Год журнала: 2024, Номер 28(1), С. 111704 - 111704

Опубликована: Дек. 27, 2024

Lung cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by high mortality rates due to its aggressive nature, metastatic potential, drug resistance. Despite advancements in conventional therapies, their efficacy is often limited systemic toxicity, poor tumor specificity, emergence resistance mechanisms. Nanomedicine has emerged as a promising approach address these challenges, leveraging unique physicochemical properties nanomaterials enhance delivery, reduce off-target effects, enable combination therapies. This review provides comprehensive overview applications lung treatment, focusing on chemotherapy, phototherapy, immunotherapy. Key strategies include development stimuli-responsive nanoparticles, active targeting mechanisms, multifunctional platforms for co-delivery therapeutic agents. Notable successes, such liposomal formulations polymeric highlight potential overcome biological barriers improve outcomes. However, significant challenges remain, including penetration, immunogenicity, scalability manufacturing, regulatory complexities. Addressing limitations through innovative design, advanced manufacturing technologies, interdisciplinary collaboration will be critical translating nanomedicine from bench bedside. Overall, represents transformative frontier therapy, offering patient outcomes quality life.

Язык: Английский

Процитировано

0