Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 73 - 73
Опубликована: Янв. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
Язык: Английский
Advances in biomimetic AIE nanoparticles for diagnosis and phototherapy
Nanoscale,
Год журнала:
2024,
Номер
16(31), С. 14707 - 14715
Опубликована: Янв. 1, 2024
This
minireview
provides
an
overview
of
the
recent
advancements
in
development
biomimetic
Aggregation-Induced
Emission
(AIE)
nanoparticles
and
their
applications
disease
diagnosis,
phototherapy,
photoimmunotherapy.
AIE
can
be
engineered
to
enable
efficient
image-guided
photodynamic
photothermal
therapies,
however,
challenges
related
immune
defense
target
specificity
persist.
To
overcome
these,
coating
materials
on
surface
nanoparticles,
which
mimic
features
functions
native
cells,
have
emerged
as
a
promising
solution.
will
highlight
synthesis
strategies
discuss
biomedical
application
nanoparticles.
Язык: Английский
Top-down bioinspired nanotheranostics with AIE luminogens
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
537, С. 216681 - 216681
Опубликована: Апрель 15, 2025
Язык: Английский
Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections
Small Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Infections
caused
by
pathogenic
bacteria
pose
a
significant
threat
to
human
health.
Fluorescent
antibiotics
present
an
innovative
material
class
that
combines
diagnostic
capabilities
with
therapeutic
effects.
offer
transformative
strategy
combining
precise
visualization
of
bacterial
activity
targeted
antimicrobial
action,
addressing
key
challenges
like
drug
resistance
and
rapid
pathogen
detection
in
diagnostics
treatment.
This
review
highlights
recent
advances
the
development
fluorescent
antibiotics,
focusing
on
chemical
strategies
such
as
click
chemistry,
amide
bond
formation,
solid‐phase
peptide
synthesis,
epoxy‐amine
addition.
Also,
practical
applications
these
probes,
ranging
from
imaging,
detection,
real‐time
visual
tracking
detailed
study
molecular
dynamics
at
cellular
level
are
discussed.
The
opportunity
combine
treatment
infectious
diseases
underscores
promise
particularly
face
escalating
resistance.
However,
despite
promise,
most
studies
confined
laboratory
settings.
To
move
forward,
continued
innovation
rigorous
clinical
validation
will
be
essential
translating
promising
tools
research
impactful
applications.
Язык: Английский
Stereoisomeric AIE Photosensitizers for Biofilm Inhibition and Host-Directed Elimination of Intracellular Multidrug-Resistant Bacteria
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Bacteria
can
form
biofilms
on
their
surfaces
or
escape
from
the
phagosomes
and
multiply
in
cytoplasm
to
become
intracellular
bacteria,
presenting
a
challenge
for
antibiotics
reach
bacterial
cells
consequently
making
treatment
difficult.
In
light
of
this,
we
employed
two
cis-trans
molecules
with
aggregation-induced
emission
(AIE)
properties,
(E)-
(Z)-TPE-EPy,
which
have
ability
hinder
Gram-positive
(G+)
bacteria
Staphylococcus
aureus
(S.
aureus)
methicillin-resistant
S.
(MRSA)
biofilm
formation
by
reactive
oxygen
species
(ROS)
eradicate
MRSA
host-directed
therapy
(HDT).
These
bind
target
mitochondria,
generate
ROS
situ,
reduce
mitochondrial
membrane
potential,
subsequently
induce
autophagy
clear
inflammation.
Also,
these
AIE
luminogens
(AIEgens)
promote
healing
wounds
infection
killing
regulating
wound
Our
findings
shed
potential
application
AIEgens
antimicrobial
developed
an
available
strategy
against
bacteria.
Язык: Английский
Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Stubborn
biofilm
infections
pose
serious
threats
to
public
health.
Clinical
practices
highly
rely
on
mechanical
debridement
and
antibiotics,
which
often
fail
lead
persistent
recurrent
infections.
The
main
culprits
are
1)
bacteria
reviving,
colonizing,
rejuvenating
biofilms,
2)
secondary
pathogen
exposure,
particularly
in
individuals
with
chronic
diseases.
Addressing
how
inhibit
revival
prevent
reinfection
simultaneously
is
still
a
major
challenge.
Herein,
an
oligo-ethylene
glycol-modified
lipophilic
cationic
photosensitizer
(PS),
TBTCP-PEG7,
developed.
It
effectively
eradicates
Methicillin-Resistant
Staphylococcus
aureus
(MRSA)
under
light
irradiation.
Furthermore,
TBTCP-PEG7-mediated
photodynamic
therapy
(PDT)
not
only
conquers
stubborn
by
downregulating
the
two-component
system
(TCS),
quorum
sensing
(QS),
virulence
factors,
thereby
reducing
intercellular
communication,
inhibiting
bacterial
regrowth
remodeling
but
also
prevents
upregulating
heat
shock
protein-related
genes
induce
immunogenetic
cell
death
(ICD)
establish
immune
memory.
In
vivo,
TBTCP-PEG7
efficiently
MRSA
adhered
medical
catheters,
stimulates
angiogenesis,
reduces
inflammatory
factor
expression,
accelerates
wound
healing.
ICD
promotes
short-term
long-term
immunological
memory
for
coping
This
two-pronged
strategy
overcomes
stubborn,
infection,
provides
theoretical
guidance
designing
next
generation
of
antibacterial
materials.
Язык: Английский