Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection DOI Open Access
Jiali Wang,

Pan Xiu,

Xin Li

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail lead persistent recurrent infections. The main culprits are 1) bacteria reviving, colonizing, rejuvenating biofilms, 2) secondary pathogen exposure, particularly in individuals with chronic diseases. Addressing how inhibit revival prevent reinfection simultaneously is still a major challenge. Herein, an oligo-ethylene glycol-modified lipophilic cationic photosensitizer (PS), TBTCP-PEG7, developed. It effectively eradicates Methicillin-Resistant Staphylococcus aureus (MRSA) under light irradiation. Furthermore, TBTCP-PEG7-mediated photodynamic therapy (PDT) not only conquers stubborn by downregulating the two-component system (TCS), quorum sensing (QS), virulence factors, thereby reducing intercellular communication, inhibiting bacterial regrowth remodeling but also prevents upregulating heat shock protein-related genes induce immunogenetic cell death (ICD) establish immune memory. In vivo, TBTCP-PEG7 efficiently MRSA adhered medical catheters, stimulates angiogenesis, reduces inflammatory factor expression, accelerates wound healing. ICD promotes short-term long-term immunological memory for coping This two-pronged strategy overcomes stubborn, infection, provides theoretical guidance designing next generation of antibacterial materials.

Language: Английский

Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology DOI Creative Commons
Ana Isabel Beltrán-Velasco, Vicente Javier Clemente‐Suárez

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

Citations

3
Top-down bioinspired nanotheranostics with AIE luminogens DOI
Xiaoyu Xu,

Luojia Chen,

Yang Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216681 - 216681

Published: April 15, 2025

Language: Английский

Citations

0
Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections DOI Creative Commons

Tan Phuoc Ton,

Richard Bright, Vi Khanh Truong

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Infections caused by pathogenic bacteria pose a significant threat to human health. Fluorescent antibiotics present an innovative material class that combines diagnostic capabilities with therapeutic effects. offer transformative strategy combining precise visualization of bacterial activity targeted antimicrobial action, addressing key challenges like drug resistance and rapid pathogen detection in diagnostics treatment. This review highlights recent advances the development fluorescent antibiotics, focusing on chemical strategies such as click chemistry, amide bond formation, solid‐phase peptide synthesis, epoxy‐amine addition. Also, practical applications these probes, ranging from imaging, detection, real‐time visual tracking detailed study molecular dynamics at cellular level are discussed. The opportunity combine treatment infectious diseases underscores promise particularly face escalating resistance. However, despite promise, most studies confined laboratory settings. To move forward, continued innovation rigorous clinical validation will be essential translating promising tools research impactful applications.

Language: Английский

Citations

0
Advances in biomimetic AIE nanoparticles for diagnosis and phototherapy DOI Creative Commons

Joe H. C. Chau,

Michelle M. S. Lee, Eric Y. Yu

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(31), P. 14707 - 14715

Published: Jan. 1, 2024

This minireview provides an overview of the recent advancements in development biomimetic Aggregation-Induced Emission (AIE) nanoparticles and their applications disease diagnosis, phototherapy, photoimmunotherapy. AIE can be engineered to enable efficient image-guided photodynamic photothermal therapies, however, challenges related immune defense target specificity persist. To overcome these, coating materials on surface nanoparticles, which mimic features functions native cells, have emerged as a promising solution. will highlight synthesis strategies discuss biomedical application nanoparticles.

Language: Английский

Citations

3
Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection DOI Open Access
Jiali Wang,

Pan Xiu,

Xin Li

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail lead persistent recurrent infections. The main culprits are 1) bacteria reviving, colonizing, rejuvenating biofilms, 2) secondary pathogen exposure, particularly in individuals with chronic diseases. Addressing how inhibit revival prevent reinfection simultaneously is still a major challenge. Herein, an oligo-ethylene glycol-modified lipophilic cationic photosensitizer (PS), TBTCP-PEG7, developed. It effectively eradicates Methicillin-Resistant Staphylococcus aureus (MRSA) under light irradiation. Furthermore, TBTCP-PEG7-mediated photodynamic therapy (PDT) not only conquers stubborn by downregulating the two-component system (TCS), quorum sensing (QS), virulence factors, thereby reducing intercellular communication, inhibiting bacterial regrowth remodeling but also prevents upregulating heat shock protein-related genes induce immunogenetic cell death (ICD) establish immune memory. In vivo, TBTCP-PEG7 efficiently MRSA adhered medical catheters, stimulates angiogenesis, reduces inflammatory factor expression, accelerates wound healing. ICD promotes short-term long-term immunological memory for coping This two-pronged strategy overcomes stubborn, infection, provides theoretical guidance designing next generation of antibacterial materials.

Language: Английский

Citations

1