Microwave-Assisted Synthesized ZnO@APTES Quantum Dots Exhibits Potent Antibacterial Efficacy Against Methicillin-Resistant Staphylococcus aureus Without Inducing Resistance

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 523 - 540

Опубликована: Янв. 1, 2025

Antibiotic resistance of many bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), has become a major threat to global health. Zinc Oxide Quantum dots (ZnO-QDs) show good antibacterial activity, but most them are insoluble in water, limiting their application range, and there is lack research on drug inducement. The water-soluble zinc oxide quantum modified by APTES (ZnO@APTES QDs) were prepared microwave assisted synthesis. Then ZnO@APTES QDs characterized through various methods. After confirmation synthesized QDs, its bactericidal effect MRSA was detected vitro vivo experiments, mechanism action analyzed. Characterization analysis revealed that the have particle size 5 nm. minimum inhibitory concentrations (MIC) determined be 64 µg mL-1 for Escherichia coli (E. coli) 32 MRSA. showed significant inhibition biofilm formation effectively disrupted mature biofilms. Notably, did not induce tolerance or even after 30 days repeated exposure, whereas antibiotics led rise bacterial MIC within 3 60-fold increase days. Mechanistic indicated positively charged interact with surfaces, altering membrane fluidity. Once inside generate reactive oxygen species (ROS), causing DNA damage cell death. Moreover, possessed biocompatibility demonstrated therapeutic efficacy against drug-resistant infections both macrophage mouse wound infection models. In summary, we highly effective shows strong other bacteria. holds potential development as new treatment agent combating antibiotic-resistant infections.

Язык: Английский

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Thermal Transport through CTAB- and MTAB-Functionalized Gold Interfaces Using Molecular Dynamics Simulations

Journal of Chemical Information and Modeling, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Thermal transport coefficients, notably the interfacial thermal conductance, were determined in planar and spherical gold interfaces functionalized with CTAB (cetyltrimethylammonium bromide) or MTAB (16-mercapto-hexadecyl-trimethylammonium using reverse nonequilibrium molecular dynamics (RNEMD) methods. The systems of interest included (111), (110), (100) facets as well nanospheres (r = 10 Å). effect metal polarizability was investigated through implementation density-readjusted embedded atom model (DR-EAM), a polarizable potential. We find that conductance is higher MTAB-capped interfaces, due large part to metal-to-ligand coupling provided by Au–S bond. Alternatively, does not couple strongly either solvent, it largely barrier heat transfer, resulting much lower conductance. Through analysis physical contact between ligand we there significantly more overlap than systems, mirroring trends observed

Язык: Английский

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Leveraging bacteria-inspired nanomaterials for targeted controlling biofilm and virulence properties of Pseudomonas aeruginosa

Microbial Pathogenesis, Год журнала: 2024, Номер 197, С. 107103 - 107103

Опубликована: Ноя. 5, 2024

Язык: Английский

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Various Methods of Synthesis and Applications of Gold-Based Nanomaterials: A Detailed Review

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

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A Sprayable Temperature-Sensitive Hydrogel Promotes Oral Ulcer Healing through NGFR/ERK Signaling Pathway

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Oral ulcer is a common oral mucosal injury disease that causes significant inconvenience and discomfort for patients. Traditional treatments, such as drugs, ointments, patches, have limitations, including low local drug utilization, short residence time on the affected area, risk of secondary from manual application. To address these issues, this study developed sprayable temperature-sensitive hydrogel (PEI/PAA/PF127-CHO/AA2G@MSN-NH2 hydrogel, PMAG) without contact injuryed mucosa by combining aldehyde-modified Pluronic F-127 (PF127-CHO), ascorbic acid 2-glucoside-loaded amino-mesoporous silica (AA2G@MSN-NH2), polyethylenimine (PEI), polyacrylic (PAA) through Schiff base reaction physical crosslinking. When sprayed onto an ulcer, PMAG exhibits excellent temperature sensitivity adhesion, rapidly adapting to forming protective film closely adheres surface. This creates stable healing environment isolating wound external stimuli. has demonstrated abilities in promoting epithelial cell proliferation migration, well antioxidant, anti-inflammatory, antibacterial properties. RNA sequencing revealed tissue repair-promoting effects are primarily mediated activating nerve growth factor receptor/extracellular signal-regulated kinase (NGFR/ERK) signaling pathway. In summary, represents advancement improving treatment ulcers offers more convenient option

Язык: Английский

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Nanostructured Bubble Thin Films—From Simple Fabrication to Scalable Applications: A Review

Nanomaterials, Год журнала: 2025, Номер 15(11), С. 868 - 868

Опубликована: Июнь 4, 2025

Several applications for nanotechnology necessitate the assembly of nanomaterials over large areas with precise orientation and density. Some techniques, such as Langmuir–Blodgett, contact printing, electric field directed assembly, flow-assisted alignment, have been used to meet a requirement. However, it remains uncertain whether these techniques can be scaling up nanomaterial thin films onto solid flexible substrates. Accordingly, this review paper addresses an issue by reviewing two recent scalable methods: blown bubble (BBFs) deposition method (BDM). It specifically offers comprehensive account film methods along their applications. also discusses how are made fabricate devices. finally provides some recommendations further research

Язык: Английский

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In Situ Stabilization of Bi Nanoparticles into the Nanopores of Modified Montmorillonite: Efficient Heterogeneous Catalysts for Reduction of 4-Nitrophenol

Langmuir, Год журнала: 2024, Номер 40(46), С. 24281 - 24291

Опубликована: Ноя. 5, 2024

Here, we report the in situ generation of Bi nanoparticles (BiNPs) into a nanoporous matrix by impregnation bismuth chloride and subsequent reduction with sodium borohydride. The was created acid activation natural montmorillonite clay under controlled conditions aim that it may serve as host for BiNPs. characterization stabilized BiNPs done using Fourier-transform infrared (FTIR), powder X-ray diffraction (PXRD), photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), field emission scanning microscopy-energy dispersive (FESEM-EDX) techniques. TEM study reveals an average particle size 7.16 nm are well-distributed on surface acid-activated clay. synthesized exhibited excellent catalytic activity degradation 4-nitrophenol (4-NP) aqueous medium remarkable results. 4-NP to 4-aminophenol (4-AP) at 25 °C, presence borohydride, brought about almost 100% conversion 6 min rate constant 0.20098 s

Язык: Английский

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A Facile Electrodeposited Fabrication of Ag, Co, and Ni Nanoparticles for Plasmonic Properties and Antibacterial Activity

Materials Today Communications, Год журнала: 2024, Номер unknown, С. 111148 - 111148

Опубликована: Ноя. 1, 2024

Язык: Английский

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Naked-eye detection of Fe3+ and photothermal applications of flexible and sustainable banana pith stabilized silver nanoparticle-rice starch composite

Emergent Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

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