Functional Nucleic Acid Nanostructures for Mitochondrial Targeting: The Basis of Customized Treatment Strategies
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1025 - 1025
Опубликована: Фев. 24, 2025
Mitochondria,
as
vital
organelles,
play
a
central
role
in
subcellular
research
and
biomedical
innovation.
Although
functional
nucleic
acid
(FNA)
nanostructures
have
witnessed
remarkable
progress
across
numerous
biological
applications,
strategies
specifically
tailored
to
target
mitochondria
for
molecular
imaging
therapeutic
interventions
remain
scarce.
This
review
delves
into
the
latest
advancements
leveraging
FNA
mitochondria-specific
cancer
therapy.
Initially,
we
explore
creation
of
FNA-based
biosensors
localized
mitochondria,
enabling
real-time
detection
visualization
critical
molecules
essential
mitochondrial
function.
Subsequently,
examine
developments
aimed
at
mitochondrial-targeted
treatments,
including
modular
nanodevices
precise
delivery
agents
programmable
disrupting
processes.
Emphasis
is
placed
on
elucidating
chemical
principles
underlying
design
mitochondrial-specific
nanotechnology
diverse
uses.
Lastly,
address
unresolved
challenges
outline
prospective
directions,
with
goal
advancing
field
encouraging
sophisticated
tools
both
academic
inquiry
clinical
applications
centered
mitochondria.
Язык: Английский
Peroxidase-mimicking activity of carbon dots modified with ethylenediaminetetraacetic acid complexes
Russian Chemical Bulletin,
Год журнала:
2025,
Номер
74(3), С. 742 - 746
Опубликована: Март 1, 2025
Язык: Английский
Stimulus-Responsive Targeted Lutein Nanoparticles for the Alleviation of Blue Light-Induced Retinal Degeneration
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Growing
concern
about
the
prolonged
exposure
to
blue
light
on
eye
health
has
driven
interest
in
bioactive
substances
that
can
help
protect
eyes.
In
this
study,
a
type
of
mitochondrion
targeted
lutein
nanoparticles
with
potential
hydrogen
(pH)
and
reactive
oxygen
species
(ROS)-responsive
capabilities
was
designed
prepared
for
retinal
degeneration
caused
by
light.
Lutein
were
initially
using
self-assembly
method
based
(3-carboxypentyl)
(triphenyl)
phosphonium
modified
casein-mannose
(CAS-Man)
conjugates.
Subsequently,
3-aminobenzeneboronic
acid
sodium
alginate
surrounded
surface
generate
hydrophilic
corona.
The
exhibited
pH-
ROS-responsive
release
properties
showed
good
mitochondrial
ability
after
4
h
incubation,
Pearson's
correlation
coefficient
0.88.
Visual
electrophysiology
results
indicated
alleviated
damage
improving
dark
adaptation,
preserving
vascular
microcirculation,
enhancing
optic
nerve
conduction
function.
Fluorescein
fundus
angiography
significantly
decreased
vessel
percentage
area
6.93
±
0.32%,
average
length
0.59-fold,
number
junctions
0.88-fold
exposure.
effectively
protected
mice
from
light-induced
reducing
ROS
production
retina
1.44-fold
inhibiting
cellular
apoptosis
2.29-fold.
These
findings
suggested
pH
provided
strategy
mitigating
degeneration.
Язык: Английский
Progress on Carbon Dots with Intrinsic Bioactivities for Multimodal Theranostics
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Carbon
dots
(CDs)
with
intrinsic
bioactivities
are
candidates
for
bioimaging
and
disease
therapy
due
to
their
diverse
bioactivities,
high
biocompatibility,
multiple
functionalities
in
multimodal
theranostics.
It
is
a
multidisciplinary
research
hotspot
that
includes
biology,
physics,
materials
science,
chemistry.
This
progress
report
discusses
the
CDs
applications
The
relationship
between
synthesis
structure
of
summarized
analyzed
from
material
chemical
perspective.
including
anti‐tumor,
antibacterial,
anti‐inflammatory
etc.
discussed
biological
points
view.
Subsequently,
optical
electronic
properties
can
be
applied
biomedical
field
physical
Based
on
functional
review
CDs,
reviewed,
diagnosis
treatment,
activity,
Unlike
previous
reviews,
this
combines
disciplines
gain
more
comprehensive
understanding
mechanisms,
functions,
bioactivities.
Язык: Английский