Harnessing the Potential of Exosomes in Therapeutic Interventions for Brain Disorders

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2491 - 2491

Опубликована: Март 11, 2025

Exosomes, which are nano-sized natural vesicles secreted by cells, crucial for intercellular communication and interactions, playing a significant role in various physiological pathological processes. Their characteristics, such as low toxicity immunogenicity, high biocompatibility, remarkable drug delivery capabilities—particularly their capacity to traverse the blood–brain barrier—make exosomes highly promising vehicles administration treatment of brain disorders. This review provides comprehensive overview exosome biogenesis isolation techniques, strategies loading functionalization exosomes, exosome-mediated barrier penetration mechanisms, with particular emphasis on recent advances exosome-based Finally, we address opportunities challenges associated utilizing system brain, summarizing barriers clinical translation proposing future research directions.

Язык: Английский

Therapeutic and prognostic values of ferroptosis signature in glioblastoma

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114597 - 114597

Опубликована: Апрель 15, 2025

Язык: Английский

Why and how citrate may sensitize malignant tumors to immunotherapy

Drug Resistance Updates, Год журнала: 2024, Номер 78, С. 101177 - 101177

Опубликована: Ноя. 26, 2024

Язык: Английский