Harnessing the Potential of Exosomes in Therapeutic Interventions for Brain Disorders

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2491 - 2491

Published: March 11, 2025

Exosomes, which are nano-sized natural vesicles secreted by cells, crucial for intercellular communication and interactions, playing a significant role in various physiological pathological processes. Their characteristics, such as low toxicity immunogenicity, high biocompatibility, remarkable drug delivery capabilities—particularly their capacity to traverse the blood–brain barrier—make exosomes highly promising vehicles administration treatment of brain disorders. This review provides comprehensive overview exosome biogenesis isolation techniques, strategies loading functionalization exosomes, exosome-mediated barrier penetration mechanisms, with particular emphasis on recent advances exosome-based Finally, we address opportunities challenges associated utilizing system brain, summarizing barriers clinical translation proposing future research directions.

Language: Английский

Therapeutic and prognostic values of ferroptosis signature in glioblastoma

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114597 - 114597

Published: April 15, 2025

Language: Английский

Why and how citrate may sensitize malignant tumors to immunotherapy

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101177 - 101177

Published: Nov. 26, 2024

Language: Английский