Surface Engineering of Magnetic Iron Oxide Nanoparticles for Breast Cancer Diagnostics and Drug Delivery
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8437 - 8461
Опубликована: Авг. 1, 2024
Data
published
in
2020
by
the
International
Agency
for
Research
on
Cancer
(IARC)
of
World
Health
Organization
show
that
breast
cancer
(BC)
has
become
most
common
globally,
affecting
more
than
2
million
women
each
year.
The
complex
tumor
microenvironment,
drug
resistance,
metastasis,
and
poor
prognosis
constitute
primary
challenges
current
diagnosis
treatment
BC.
Magnetic
iron
oxide
nanoparticles
(MIONPs)
have
emerged
as
a
promising
nanoplatform
diagnostic
imaging
well
therapeutic
drug-targeted
delivery
due
to
their
unique
physicochemical
properties.
extensive
surface
engineering
given
rise
multifunctionalized
MIONPs.
In
this
review,
latest
advancements
modification
strategies
MIONPs
over
past
five
years
are
summarized
categorized
constrast
agents
platforms.
Additionally,
remaining
future
prospects
MIONPs-based
targeted
discussed.
Язык: Английский
Recent advance on extracellular vesicle labeling: From strategy to probe
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
534, С. 216601 - 216601
Опубликована: Март 10, 2025
Язык: Английский
Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
Stem
cell-derived
extracellular
vesicles
(EVs)
offer
a
promising
cell-free
approach
for
cardiovascular
regenerative
medicine.
In
this
study,
we
developed
magnetically
labeled
induced
pluripotent
stem
EVs
(magneto-iPSC-EVs)
encapsulated
with
superparamagnetic
iron
oxide
(SPIO)
nanoparticles
image-guided
treatment
of
myocardial
infarction,
in
which
that
can
be
detected
by
both
magnetic
resonance
imaging
(MRI)
and
particle
(MPI).
iPSC-EVs
were
isolated,
characterized
per
MISEV2023
guidelines,
loaded
SuperSPIO20
using
optimized
electroporation
conditions
(300
V,
2
×
10
ms
pulses),
achieving
high
loading
efficiency
1.77
ng
Fe/10
6
EVs.
vitro
results
show
magneto-iPSC-EVs
sensitively
MPI
MRI,
detectability
approximately
7
mouse
ischemia-reperfusion
model,
intramyocardially
injected
(2
9
)
imaged
non-invasively
vivo
days
ex
the
presence
confirmed
Prussian
blue
staining.
Therapeutically,
native
significantly
improved
cardiac
function,
37.3%
increase
left
ventricular
ejection
fraction
61.0%
reduction
scar
size.
This
study
highlights
potential
as
medicine,
offering
non-invasive
capabilities
therapeutic
benefits
repair.
Язык: Английский
Development of Iron Oxide Nanochains as a Sensitive Magnetic Particle Imaging Tracer for Cancer Detection
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
The
advancement
of
imaging
technologies
plays
a
crucial
role
in
improving
the
diagnosis
and
monitoring
diseases,
including
cancer.
This
study
introduces
new
design
iron
oxide-based
nanoparticles
specifically
developed
for
magnetic
particle
(MPI),
aimed
at
tracking
diagnosing
breast
cancer
more
effectively.
By
precisely
controlling
size,
shape,
properties
these
nanoparticles,
we
enhance
responsiveness
MPI,
resulting
an
increased
signal.
In
our
research,
established
novel
synthetic
route
fabricating
oxide
nanochains
(FeONCs)
characterized
by
their
uniform
shape
which
contribute
to
high
suitable
MPI
applications.
Initial
results
indicate
FeONCs
exhibit
superior
compared
conventional
spherical
superparamagnetic
nanocubes,
reported
nanoworm-type
structures.
Magnetic
relaxometry
studies
revealed
that
provide
higher
sensitivity
than
commonly
used
VivoTrax
Synomag
D50
D70
MPI.
Further,
size
significantly
influence
cellular
uptake.
vivo
experiments
using
orthotopic
mouse
models
allow
us
assess
biocompatibility
characteristics
confirming
efficacy.
Furthermore,
conjugating
with
RGD
peptide,
ability
target
cancer,
establishing
them
as
promising
tracers
applications
sensitivity.
Thus,
findings
highlight
improve
quality,
facilitating
early
detection
accurate
paves
way
innovative
diagnostic
strategies
personalized
treatment
options.
Future
research
will
focus
on
fine-tuning
surface
chemistry
further
targeting
efficiency
optimization
practice
clinical
applications,
particularly
MPI-based
hyperthermia
therapy.
Язык: Английский
Unveiling Invisible Extracellular Vesicles: Cutting‐Edge Technologies for Their in Vivo Visualization
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(5)
Опубликована: Сен. 1, 2024
ABSTRACT
Extracellular
vesicles
(EVs),
nanosized
lipid
bilayer
released
by
nearly
all
types
of
cells,
play
pivotal
roles
as
intercellular
signaling
mediators
with
diverse
biological
activities.
Their
adaptability
has
attracted
interest
in
exploring
their
role
disease
biomarker
theranostics.
However,
the
vivo
biodistribution
and
pharmacokinetic
profiles
EVs,
particularly
following
administration
into
living
subjects,
remain
unclear.
Thus,
imaging
is
vital
to
enhance
our
understanding
homing
retention
patterns,
blood
tissue
half‐life,
excretion
pathways
exogenous
thereby
advancing
real‐time
monitoring
within
systems
therapeutic
applications.
This
review
examines
state‐of‐the‐art
methods
including
EV
labeling
various
agents,
optical
imaging,
magnetic
resonance
nuclear
imaging.
The
strengths
weaknesses
each
technique
are
comprehensively
explored,
emphasizing
clinical
translation.
Despite
potential
EVs
cancer
theranostics,
achieving
a
thorough
behavior
challenging.
highlights
urgency
addressing
current
questions
biology
applications
EVs.
It
underscores
need
for
continued
research
unravel
complexities
surrounding
implications.
By
identifying
these
challenges,
this
contributes
ongoing
efforts
optimize
techniques
use.
Ultimately,
bridging
gap
between
advancements
will
facilitate
integration
EV‐based
marking
crucial
step
toward
harnessing
full
medical
practice.
Язык: Английский