Point-of-Care Testing: The Convergence of Innovation and Accessibility in Diagnostics

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Over the years, evolution of point-of-care testing (POCT) has been driven by technological advancements in materials, design, and artificial intelligence, as well breakthrough developments wearable technologies. These innovations are shifting diagnostics from centralized medical facilities to individual homes, meeting growing demand for personalized healthcare. This Review explores recent binding-based assay technologies over past two focusing on platforms such traditional flow assays (lateral vertical flow), fully integrated microfluidic devices, biosensor-integrated systems POCT applications. It emphasizes role optical electrochemical detection methods, which essential ensuring sensitivity, specificity, reliability required a POCT. offer advantages including ease use, high diagnostic accuracy, rapid clinical assessment, cost-effectiveness manufacturing consumables. Additionally, highlights current challenges future perspectives delivering healthcare through portable that operate sample-in, result-out basis.

Язык: Английский

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A silver auto-catalyzed plasmonic enzyme-linked immunosorbent assay for colorimetric and fluorescent detection of neutrophil gelatinase associated lipocalin (NGAL)

Microchemical Journal, Год журнала: 2024, Номер 206, С. 111551 - 111551

Опубликована: Сен. 1, 2024

Язык: Английский

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Upconverting Nanoparticles and Cu(I) Complex-Based Platform for Oxygen Sensing, Thermometry, and Emission Color Tuning

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

Multifunctional nanoplatforms combine different material properties to meet a wide range of applications, allowing highly customizable systems. In this rapidly advancing research field, we introduce multifunctional nanomaterial based on the synergy between Tm3+-doped upconverting nanoparticles (UCNPs) and Cu(I) complex (CuCom). This is designed for oxygen sensing, optical thermometry, emission color tuning. various concentrations, CuCom was electrostatically integrated into mesoporous silica shell surrounding core UCNPs (UCNP@mSiO2). The optimized system, UCNP@mSiO2@CuCom-10, evaluated applications. Due spectral overlap absorption emission, excitation at 980 nm allows most UV-blue output from be transferred via luminescent resonance energy transfer (LRET), producing red molecule. remaining Tm3+ enables while CuCom's sensitivity molecular supports its application in gas sensing. upconversion mode, nanoplatform achieved Stern–Volmer constant O2 sensing 1.64 demonstrated thermometric relative sensitivities 0.9% 1% K–1 room temperature, with linear response 193 373 K. Additionally, UCNP@mSiO2@CuCom-10 can tuned blue white yellow, by varying adding further functionality system. platform suggests promising applications biology, medicine, environmental monitoring.

Язык: Английский

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Systematic optimization of UCNPs-LFA for Helicobacter pylori nucleic acid detection at point-of-care

Microchimica Acta, Год журнала: 2024, Номер 191(11)

Опубликована: Окт. 7, 2024

Язык: Английский

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