Point-of-Care Testing: The Convergence of Innovation and Accessibility in Diagnostics
Shine Augustine,
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Anandharaman Venkadesh,
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Sandeep Kaushal
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et al.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Over
the
years,
evolution
of
point-of-care
testing
(POCT)
has
been
driven
by
technological
advancements
in
materials,
design,
and
artificial
intelligence,
as
well
breakthrough
developments
wearable
technologies.
These
innovations
are
shifting
diagnostics
from
centralized
medical
facilities
to
individual
homes,
meeting
growing
demand
for
personalized
healthcare.
This
Review
explores
recent
binding-based
assay
technologies
over
past
two
focusing
on
platforms
such
traditional
flow
assays
(lateral
vertical
flow),
fully
integrated
microfluidic
devices,
biosensor-integrated
systems
POCT
applications.
It
emphasizes
role
optical
electrochemical
detection
methods,
which
essential
ensuring
sensitivity,
specificity,
reliability
required
a
POCT.
offer
advantages
including
ease
use,
high
diagnostic
accuracy,
rapid
clinical
assessment,
cost-effectiveness
manufacturing
consumables.
Additionally,
highlights
current
challenges
future
perspectives
delivering
healthcare
through
portable
that
operate
sample-in,
result-out
basis.
Language: Английский
A silver auto-catalyzed plasmonic enzyme-linked immunosorbent assay for colorimetric and fluorescent detection of neutrophil gelatinase associated lipocalin (NGAL)
Microchemical Journal,
Journal Year:
2024,
Volume and Issue:
206, P. 111551 - 111551
Published: Sept. 1, 2024
Language: Английский
Systematic optimization of UCNPs-LFA for Helicobacter pylori nucleic acid detection at point-of-care
Birui Jin,
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Siyu Li,
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Chuyao Zhang
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et al.
Microchimica Acta,
Journal Year:
2024,
Volume and Issue:
191(11)
Published: Oct. 7, 2024
Language: Английский
Upconverting Nanoparticles and Cu(I) Complex-Based Platform for Oxygen Sensing, Thermometry, and Emission Color Tuning
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Multifunctional
nanoplatforms
combine
different
material
properties
to
meet
a
wide
range
of
applications,
allowing
highly
customizable
systems.
In
this
rapidly
advancing
research
field,
we
introduce
multifunctional
nanomaterial
based
on
the
synergy
between
Tm3+-doped
upconverting
nanoparticles
(UCNPs)
and
Cu(I)
complex
(CuCom).
This
is
designed
for
oxygen
sensing,
optical
thermometry,
emission
color
tuning.
various
concentrations,
CuCom
was
electrostatically
integrated
into
mesoporous
silica
shell
surrounding
core
UCNPs
(UCNP@mSiO2).
The
optimized
system,
UCNP@mSiO2@CuCom-10,
evaluated
applications.
Due
spectral
overlap
absorption
emission,
excitation
at
980
nm
allows
most
UV-blue
output
from
be
transferred
via
luminescent
resonance
energy
transfer
(LRET),
producing
red
molecule.
remaining
Tm3+
enables
while
CuCom's
sensitivity
molecular
supports
its
application
in
gas
sensing.
upconversion
mode,
nanoplatform
achieved
Stern–Volmer
constant
O2
sensing
1.64
demonstrated
thermometric
relative
sensitivities
0.9%
1%
K–1
room
temperature,
with
linear
response
193
373
K.
Additionally,
UCNP@mSiO2@CuCom-10
can
tuned
blue
white
yellow,
by
varying
adding
further
functionality
system.
platform
suggests
promising
applications
biology,
medicine,
environmental
monitoring.
Language: Английский