Hyaluronic Acid‐Based Self‐Healing Hydrogels for Diabetic Wound Healing DOI Open Access

Anish Chhillar,

Amit Jaiswal

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Дек. 25, 2024

Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due their impaired healing from poor circulation and high blood sugar, increased risk of infection potential for severe complications like amputation, all compounded by peripheral neuropathy chronic inflammation. Most therapies dressings DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional wounds. Motional wounds easy-to-split that experience tension, compression, movement caused stress now then. Hyaluronic acid (HA) based stand out among other biomaterials ability cover irregular wound surfaces, maintain moist environment, repair themselves when ruptured, exhibit excellent biocompatibility. These damages recover the functional properties during healing. also act as therapeutic delivery vehicles tissue regeneration systems. This review demonstrates HA-based Due its capabilities, these offer customized approach The critically examines challenges future directions in

Язык: Английский

Advances in ionic liquid-based antimicrobial wound healing platforms DOI

Mahin Abdollahi,

Aysan Baharian,

Masoumeh Mohamadhoseini

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(38), С. 9478 - 9507

Опубликована: Янв. 1, 2024

Wound infections, marked by the proliferation of microorganisms at surgical sites, necessitate development innovative wound dressings with potent bactericidal properties to curb microbial growth and prevent bacterial infiltration. This study explores recent strides in utilizing ionic liquid-based polymers as highly promising antimicrobial agents for advanced healing applications. Specifically, cationic containing quaternary ammonium, imidazolium, guanidinium, pyridinium, triazolium, or phosphonium groups have emerged exceptionally effective compounds. Their mechanism action involves disrupting membranes, thereby preventing resistance minimizing toxicity mammalian cells. comprehensive review not only elucidates intricate dynamics skin's immune response various stages but also delves into synthesis methodologies polymers. By spotlighting practical applications dressings, particularly those incorporating materials, this aims lay groundwork future research endeavors burgeoning field. Through a nuanced examination these advancements, article seeks contribute ongoing progress developing cutting-edge platforms that can effectively address challenges posed infections wounds.

Язык: Английский

Процитировано

4

Fe/Se nanocomposite-loaded chitosan/alginate films for wound healing DOI
Dimpy Bhardwaj,

Vatan Chawla,

Aastha Gupta

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141626 - 141626

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Enhanced carbon dispersion of polyacrylamide/sodium alginate hydrogels via irregular copolymerization imidazolyl ionic liquid for flexible sensor DOI

Hongping Tong,

Shuangqing Li,

Xiuling Dong

и другие.

Journal of Polymer Research, Год журнала: 2025, Номер 32(4)

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Ultrahard and Ultraflexible Supramolecular Hydrogel with Superenergy Dissipating Structure for Biomimetic Skin DOI
Bo Chen, Ziyi Liu,

Ziyi Shen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(51), С. 70891 - 70905

Опубликована: Дек. 11, 2024

How to integrate the "soft" (flexibility and self-healing properties) "hard" (shape retention) into supramolecular hydrogel system is an attractive challenge. In this work, a with energy dissipation structure designed prepared for intelligent biomimetic skin. Lignin molecules disulfide bonds of fracture healing activities are introduced through covalent bonds. A large number hydrophobic interactions ionic constitute cross-linking hydrogel. These structures endow properties 1200% elongation at break 92.5% rate. The between lignin macromolecules give can effectively absorb work external forces on system, thus maintaining chemical structure, shape, resistivity. Furthermore, shows good biocompatibility, antibacterial properties, tissue fluid removal wound promoting sensing output characteristics. This binding biomass-based has important reference value design hydrogels both properties.

Язык: Английский

Процитировано

2

Hyaluronic Acid‐Based Self‐Healing Hydrogels for Diabetic Wound Healing DOI Open Access

Anish Chhillar,

Amit Jaiswal

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Дек. 25, 2024

Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due their impaired healing from poor circulation and high blood sugar, increased risk of infection potential for severe complications like amputation, all compounded by peripheral neuropathy chronic inflammation. Most therapies dressings DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional wounds. Motional wounds easy-to-split that experience tension, compression, movement caused stress now then. Hyaluronic acid (HA) based stand out among other biomaterials ability cover irregular wound surfaces, maintain moist environment, repair themselves when ruptured, exhibit excellent biocompatibility. These damages recover the functional properties during healing. also act as therapeutic delivery vehicles tissue regeneration systems. This review demonstrates HA-based Due its capabilities, these offer customized approach The critically examines challenges future directions in

Язык: Английский

Процитировано

2