Skin‐Inspired and Self‐Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Diabetic wounds are refractory and recurrent diseases that necessitate the development of multifunctional dressings. Inspired by structure function skin, we herein delicately design a novel swollen hydrophobic hydrogel (QL@MAB) composed methyl acrylate (MA) (3-acrylamidophenyl)boronic acid (AAPBA) network co-loaded with antioxidant quercetin (Q) antibiotic levofloxacin (L) for efficient diabetic wound therapy. The MA segments undergo phase separation to form dense "epidermis", ensuring prolonged drug diffusion, long-term water retention, high content. Meanwhile, AAPBA generate glucose-labile "sweat pores" via borate ester bonds polyphenol Q. Upon encountering hyperglycemic microenvironment, dilated due cleavage exposure diffusion channel, facilitating release accelerated healing. In infected rats, QL@MAB achieves rapid debridement re-epithelization while promoting angiogenesis, hair follicle regeneration, extracellular matrix remodeling. Taken together, this study not only represents multipronged dressing effective interventions but also contributes rational smart hydrogels tailored biomedical applications.

Язык: Английский

Bio-based polyurethane networks/ graphene oxide composites with conductive, stretchable, antibacterial, fire-resistant, antioxidative, self-healable and reprocessable, properties

Materials Today Chemistry, Год журнала: 2025, Номер 44, С. 102584 - 102584

Опубликована: Фев. 10, 2025

Язык: Английский