Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101595 - 101595
Опубликована: Фев. 19, 2025
Язык: Английский
Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
skeleton
is
highly
innervated
by
numerous
nerve
fibers.
These
fibers,
in
addition
to
transmitting
information
within
the
bone
and
mediating
sensations,
play
a
crucial
role
regulating
tissue
formation
regeneration.
Traditional
engineering
(BTE)
often
fails
achieve
satisfactory
outcomes
when
dealing
with
large-scale
defects,
which
frequently
related
lack
of
effective
reconstruction
neurovascular
network.
In
recent
years,
increasing
research
has
revealed
critical
nerves
metabolism.
Nerve
fibers
regulate
cells
through
neurotransmitters,
neuropeptides,
peripheral
glial
cells.
Furthermore,
also
coordinate
vascular
immune
systems
jointly
construct
microenvironment
favorable
for
As
signaling
driver
formation,
neuroregulation
spans
entire
process
physiological
activities
from
embryonic
postmaturity
remodeling
repair.
However,
there
currently
comprehensive
summaries
these
regulatory
mechanisms.
Therefore,
this
review
sketches
out
function
during
Then,
we
elaborate
on
mechanisms
coupling
neuromodulation
immunity.
Finally,
discuss
several
novel
strategies
neuro-bone
(NBTE)
based
bone,
focusing
coordinated
regeneration
tissue.
Язык: Английский
Tumoral Nanovesicles-Loaded Magnetotactic Bacteria for Tumor-Targeted Therapy under a Swing Magnetic Field
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Tumor
heterogeneity
poses
numerous
challenges
for
targeted
drug
therapy.
Although
tumor
cell-derived
nanovesicles
(NVs)
have
emerged
as
an
intriguing
method
targeting,
how
to
exert
the
antitumor
effect
after
targeting
remains
a
key
concern.
Magnetotactic
bacteria
(MTB)
synthesize
chain-like
magnetite
(Fe3O4)
crystals
with
inherent
magnetic
moments,
which
could
generate
significant
torque
under
desired
field
and
move
along
using
their
own
flagella.
Herein,
composite
of
MTB
AMB-1
NVs
was
fabricated
via
electrostatic
adsorption
where
transport
site
by
guiding
field,
while
also
assist
in
binding
cells.
Subsequently,
influence
swing
(sMF),
physical
stimuli
on
cells,
inducing
changes
mitochondrial
membrane
potential
cellular
reactive
oxygen
species
(ROS).
Finally,
it
is
revealed
that
NVs-loaded
induced
decrease
viability
significantly
inhibited
growth
tumors
vivo
sMF.
Therefore,
remote
control
guidance
production,
highly
promising
advance
development
therapeutic
strategies
context
heterogeneity.
Язык: Английский