Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113894 - 113894
Опубликована: Май 1, 2025
Язык: Английский
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113894 - 113894
Опубликована: Май 1, 2025
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
In this study, we reported a cationic azobenzene (Azo) tag to increase the retention of camptothecin (CPT) prodrugs in liposomes driven by π-π stacking interaction between Azo. Compared with CPT prodrug without Azo, liposome-encapsulating Azo-linked (AzoCPT-Lips) exhibited slower leakage plasma and longer blood circulation time mice. The AzoCPT-Lips had high encapsulation efficiency (95%), loading capacity (20%, weight), good storage stability. AzoCPT was efficiently taken up 4T1 tumor cells (100-fold higher than CPT) readily converted into active cytoplasm exert 10-fold cytotoxicity free CPT. More importantly, resulted 5-20 times distribution that solution or those other tissues, which further led more potent antitumor activity lower toxicities breast cancer xenograft. Such Azo represents an effective strategy for developing liposomal drugs improved efficacy.
Язык: Английский
Процитировано
0Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 340, С. 126305 - 126305
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113894 - 113894
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0