Cationic Azobenzene Tag to Enhance Liposomal Prodrug Retention and Tumor-Targeting Prodrug Activation for Improved Antitumor Efficacy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

In this study, we reported a cationic azobenzene (Azo) tag to increase the retention of camptothecin (CPT) prodrugs in liposomes driven by π-π stacking interaction between Azo. Compared with CPT prodrug without Azo, liposome-encapsulating Azo-linked (AzoCPT-Lips) exhibited slower leakage plasma and longer blood circulation time mice. The AzoCPT-Lips had high encapsulation efficiency (95%), loading capacity (20%, weight), good storage stability. AzoCPT was efficiently taken up 4T1 tumor cells (100-fold higher than CPT) readily converted into active cytoplasm exert 10-fold cytotoxicity free CPT. More importantly, resulted 5-20 times distribution that solution or those other tissues, which further led more potent antitumor activity lower toxicities breast cancer xenograft. Such Azo represents an effective strategy for developing liposomal drugs improved efficacy.

Language: Английский

Porphyrin doped europium/black phosphorus nanoarchitectonics as the sensor of L-arginine and gram-negative bacteria

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 340, P. 126305 - 126305

Published: May 1, 2025

Language: Английский

Nucleic acid aptamer-based biosensor for health monitoring: A review and future prospects

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113894 - 113894

Published: May 1, 2025

Language: Английский