Ultrasound-assisted immunotherapy for malignant tumour DOI Creative Commons
Xiaowen Cai, Yujie Liu,

Guosheng Luo

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 13, 2025

Malignant tumour represents a significant global public health concern. The advent of immunotherapy has brought about revolutionary shift in the landscape treatment, offering ray hope to patients across globe. Immunotherapy strategies have demonstrated considerable promise clinical trials. However, immunosuppressive environment within microenvironment constituted obstacle advancement immunotherapies. It is therefore imperative develop more efficacious and personalised approaches. utilisation non-invasive ultrasound-assisted promising strategy. Ultrasound capacity induce an immune response stimulate other drugs achieve specific response, thereby reducing toxic side effects treatment enhancing outcome immunotherapy. This paper presents systematic introduction various mechanisms related ultrasound reviews recent advancements immunotherapy, including ultrasonic ablation, combined application with contrast agents, sonodynamic therapy.

Language: Английский

Tumor Treating Fields and Combination Therapy in Management of Brain Oncology DOI Open Access
Ruilin Liu,

James H. Huang,

Xiaoming Qi

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1211 - 1211

Published: April 2, 2025

Glioblastoma (GBM) remains a challenging cancer to treat with limited effective therapies. Standard treatments, including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, offer marginal survival benefits but are often by side effects drug resistance. Temozolomide is the most commonly used chemotherapy; however, resistance lack of efficacy in recurrent GBM hinder its success. Tumor treating fields (TTFields), novel non-invasive modality that utilizes alternating electric fields, have recently emerged as promising treatment for GBM. TTFields work disrupting function mitotic spindle inducing apoptosis cells. They can be especially when combined other enhance delivery paired chemotherapy increasing permeability blood-brain barrier cell membranes, leading more tumor inhibition. Similarly, increase sensitivity radiation therapy improve therapies, such sorafenib particularly extra-cranial tumors. The Optune device, primary medical device TTFields' delivery, offers convenient versatile option, allowing remote care exhibiting fewer adverse effects. This review discusses potential valuable addition treatment, combination highlights device's clinical applications.

Language: Английский

Citations

0
Ultrasound-assisted immunotherapy for malignant tumour DOI Creative Commons
Xiaowen Cai, Yujie Liu,

Guosheng Luo

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 13, 2025

Malignant tumour represents a significant global public health concern. The advent of immunotherapy has brought about revolutionary shift in the landscape treatment, offering ray hope to patients across globe. Immunotherapy strategies have demonstrated considerable promise clinical trials. However, immunosuppressive environment within microenvironment constituted obstacle advancement immunotherapies. It is therefore imperative develop more efficacious and personalised approaches. utilisation non-invasive ultrasound-assisted promising strategy. Ultrasound capacity induce an immune response stimulate other drugs achieve specific response, thereby reducing toxic side effects treatment enhancing outcome immunotherapy. This paper presents systematic introduction various mechanisms related ultrasound reviews recent advancements immunotherapy, including ultrasonic ablation, combined application with contrast agents, sonodynamic therapy.

Language: Английский

Citations

0