Recently,
hydrogels
have
been
investigated
for
the
controlled
release
of
bioactive
molecules,
such
as
living
cell
encapsulation
and
matrices.
Due
to
their
remote
controllability
quick
response,
are
widely
used
various
applications,
including
drug
delivery.
The
rate
extent
which
drugs
reach
targets
highly
dependent
on
carriers
in
delivery
systems;
therefore
demand
biodegradable
intelligent
is
progressively
increasing.
nature
hydrogel
has
created
much
interest
its
use
systems.
first
part
this
review
focuses
emerging
fabrication
strategies
hydrogel,
physical
chemical
cross-linking,
well
radiation
cross-linking.
second
describes
applications
fields,
In
end,
an
overview
application
prepared
from
several
natural
polymers
presented.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(11)
Опубликована: Янв. 2, 2024
Oxidative
stress
is
a
biochemical
process
that
disrupts
the
redox
balance
due
to
an
excess
of
oxidized
substances
within
cell.
closely
associated
with
multitude
diseases
and
health
issues,
including
cancer,
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
inflammatory
conditions,
aging.
Therefore,
developing
antioxidant
treatment
strategies
has
emerged
as
pivotal
area
medical
research.
Hydrogels
have
garnered
considerable
attention
their
exceptional
biocompatibility,
adjustable
physicochemical
properties,
capabilities
for
drug
delivery.
Numerous
hydrogels
been
developed
proven
effective
in
alleviating
oxidative
stress.
In
pursuit
more
treatments
stress-related
there
urgent
need
advanced
fabrication
multifunctional
hydrogels.
Consequently,
authors'
focus
will
be
on
possess
reactive
oxygen
species
nitrogen
scavenging
capabilities,
role
therapy
evaluated.
Herein,
mechanisms
design
applications
are
discussed
systematically
order
provide
critical
insights
further
advancements
field.
ACS Omega,
Год журнала:
2023,
Номер
8(9), С. 8172 - 8189
Опубликована: Фев. 20, 2023
Wound
healing
is
a
complex
and
dynamic
physiological
process
consisting
of
series
cellular
molecular
events
that
initiate
immediately
after
tissue
lesion,
to
reconstruct
the
skin
layer.
It
indubitable
patients
with
chronic
wounds,
severely
infected
or
any
metabolic
disorder
wound
microenvironment
always
endure
severe
pain
discomfort
affect
their
quality
life.
essential
treat
wounds
for
conserving
physical
as
well
mental
well-being
affected
convalescing
improve
For
supporting
augmenting
process,
selection
pertinent
dressing
essential.
A
substantial
reduction
in
duration,
disability,
associated
cost,
risk
recurrent
infections
can
be
achieved
via
engineering
dressings.
Hydrogels
play
leading
role
path
ideal
Hydrogels,
comprising
water
large
extent,
providing
moist
environment,
being
comfortable
patients,
having
biocompatible
biodegradable
properties,
have
found
success
suitable
dressings
market.
The
exploitation
hydrogels
increasing
perpetually
substantiation
broader
therapeutic
actions
owing
resemblance
dermal
tissues,
capability
stimulate
partial
regeneration,
ability
incorporate
moieties
promoting
healing.
This
review
entails
properties
hydrogel
healing,
types
hydrogels,
cross-linking
mechanisms,
design
considerations,
formulation
strategies
engineering.
Various
categories
fabricated
recently
are
discussed
based
on
gel
network
composition,
degradability,
chemical
which
provide
an
outlook
regarding
importance
tailoring
physicochemical
hydrogels.
examples
marketed
also
incorporated
along
future
perspectives
challenges
them.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 181 - 207
Опубликована: Фев. 2, 2024
Peptide
molecules
have
design
flexibility,
self-assembly
ability,
high
biocompatibility,
good
biodegradability,
and
easy
functionalization,
which
promote
their
applications
as
versatile
biomaterials
for
tissue
engineering
biomedicine.
In
addition,
the
functionalization
of
self-assembled
peptide
nanomaterials
with
other
additive
components
enhances
stimuli-responsive
functions,
promoting
function-specific
that
induced
by
both
internal
external
stimulations.
this
review,
we
demonstrate
recent
advance
in
molecular
design,
self-assembly,
functional
tailoring,
biomedical
peptide-based
nanomaterials.
The
strategies
on
synthesis
single,
dual,
multiple
various
dimensions
are
analyzed,
regulation
active
such
metal/metal
oxide,
DNA/RNA,
polysaccharides,
photosensitizers,
2D
materials,
others
discussed.
designed
temperature-,
pH-,
ion-,
light-,
enzyme-,
ROS-responsive
abilities
drug
delivery,
bioimaging,
cancer
therapy,
gene
antibacterial,
well
wound
healing
dressing
presented
This
comprehensive
review
provides
detailed
methodologies
advanced
techniques
from
biology,
materials
science,
nanotechnology,
will
guide
inspire
level
peptides
specific
functions
applications.
Advanced Healthcare Materials,
Год журнала:
2020,
Номер
10(6)
Опубликована: Дек. 4, 2020
Abstract
The
use
of
conductive
materials
to
promote
the
activity
electrically
responsive
cells
is
an
effective
means
accelerating
wound
healing.
This
article
focuses
on
recent
advancements
in
materials,
with
emphasis
overviewing
their
incorporation
non‐conducting
polymers
fabricate
electroactive
dressings.
characteristics
these
dressings
are
deliberated,
and
mechanisms
how
they
accelerate
healing
process
discussed.
Potential
directions
for
future
development
potential
monitoring
course
vivo
concomitantly
also
proposed.
