International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5831 - 5831
Опубликована: Май 23, 2022
Polylactic
acid-glycolic
acid
(PLGA)
has
been
widely
used
in
bone
tissue
engineering
due
to
its
favorable
biocompatibility
and
adjustable
biodegradation.
3D
printing
technology
can
prepare
scaffolds
with
rich
structure
function,
is
one
of
the
best
methods
obtain
for
repair.
This
review
systematically
summarizes
research
progress
3D-printed,
PLGA-based
scaffolds.
The
properties
modified
components
are
introduced
detail.
influence
method
change
process
analyzed.
advantages
disadvantages
their
applications
illustrated
by
several
examples.
Finally,
we
briefly
discuss
limitations
future
development
direction
current
materials
Journal of Medical Microbiology,
Год журнала:
2021,
Номер
70(5)
Опубликована: Май 7, 2021
Antimicrobial
resistance
(AMR)
is
one
of
the
greatest
global
health
challenges
modern
times
and
its
prevalence
rising
worldwide.
AMR
within
bacteria
reduces
efficacy
antibiotics
increases
both
morbidity
mortality
associated
with
bacterial
infections.
Despite
this
growing
risk,
few
a
novel
mode
action
are
being
produced,
leading
to
lack
that
can
effectively
treat
infections
AMR.
Metals
have
history
antibacterial
use
but
upon
discovery
antibiotics,
often
became
overlooked
as
agents.
Meanwhile,
metal-based
complexes
been
used
treatments
for
other
diseases,
such
gold-containing
drug
auranofin,
rheumatoid
arthritis.
Metal-based
compounds
modes
provide
an
advantage
treatment
conventional
antibiotics.
In
review,
activity,
action,
potential
systemic
number
discussed.
The
current
limitations
these
highlighted
determine
if
agents
solution
infections,
especially
those
resistant
Abstract
Tissue
engineering
has
emerged
as
an
interesting
field
nowadays;
it
focuses
on
accelerating
the
auto-healing
mechanism
of
tissues
rather
than
organ
transplantation.
It
involves
implanting
In
Vitro
cultured
initiative
tissue
or
a
scaffold
loaded
with
regenerating
ingredients
at
damaged
area.
Both
techniques
are
based
use
biodegradable
,
biocompatible
polymers
scaffolding
materials
which
either
derived
from
natural
(e.g.
alginates,
celluloses,
and
zein)
synthetic
sources
PLGA,
PCL,
PLA).
This
review
discusses
in
detail
recent
applications
different
biomaterials
highlighting
targeted
besides
vitro
vivo
key
findings.
As
well,
smart
chitosan)
fascinating
candidates
they
capable
elucidating
chemical
physical
transformation
response
to
external
stimuli
temperature,
pH,
magnetic
electric
fields).
Recent
trends
summarized
this
stem
cells,
3D
printing
techniques,
most
4D
approach
relies
produce
dynamic
resembling
tissue.
Furthermore,
application
advanced
provides
hope
for
researchers
recognize
COVID-19/host
interaction,
also,
presents
promising
solution
rejuvenate
destroyed
lung
tissues.
Graphical
abstract
Water,
Год журнала:
2023,
Номер
15(3), С. 384 - 384
Опубликована: Янв. 17, 2023
Removing
organic
pollutants,
textile
dyes,
and
pharmaceutical
wastes
from
the
water
bodies
has
become
an
essential
requirement
for
a
safe
environment.
Therefore,
present
study
aimed
to
prepare
semiconductor
zinc
oxide
nanoparticles
(ZnO
NPs)
plasmonic
Ag-supported
ZnO
nanocomposite
(ZnO–Ag)
using
environmentally
friendly
bio-approach
as
alternative
hazardous
synthesis
approaches.
NPs
ZnO–Ag
were
characterized
by
UV–Vis
diffuse
reflectance
spectroscopy
(UV–DRS)
(the
exhibited
absorption
band
between
450–550
nm,
attributed
Ag
surface
plasmon
resonance
(SPR)),
Photoluminescence
(PL)
spectral
investigation,
which
revealed
PL
emission
intensity
of
was
lower
than
pure
NPs,
describing
extended
electron-hole
pair
(e--h+)
lifespan
photogenerated
charge
carriers,
Fourier
transform
infrared
(FTIR),
FT-Raman,
X-ray
diffraction
(XRD)
analyses
deduced.
In
addition,
energy
dispersive
(SEM-EDX),
transmission
electron
microscopy
(TEM),
thermogravimetric
analysis
(TGA)
performed
further
ascertained
successful
biosynthesis
thermally
stable
Nps
nanocomposite.
The
as-prepared
displayed
increased
photocatalytic
characteristics
due
decline
in
bandgap
3.02
eV
2.90
(ZnO–Ag
nanocomposite).
activity
developed
degradation
methylene
blue
(MB)
dye,
primary
industry
released
water-pollutant,
conducted
under
UV
light
irradiation.
Meanwhile,
maximum
%
MB
dye
molecules
attained
98.0
after
60
min
exposure
UV-light
Increased
nanocomposites
faster
rate
achieved
deposition
(SPR)
effect
possessed
NPs.
oxidative
route
that
resulted
production
hydroxyl
radicals
(OH•).
SPR
photocatalyst
induced
synergistic
enhancement
optical
response
separation
photo-induced
carriers.
combined
gives
comprehensive
information
directions
future
research
on
noble
metal-modified
nanocatalysts
direct
applications
water.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2606 - 2606
Опубликована: Сен. 14, 2024
Poly(lactic-co-glycolic
acid)
(PLGA)
is
a
widely
used
biodegradable
and
biocompatible
copolymer
in
drug
delivery
systems
(DDSs).
In
this
article,
we
highlight
the
critical
physicochemical
properties
of
PLGA,
including
its
molecular
weight,
intrinsic
viscosity,
monomer
ratio,
blockiness,
end
caps,
that
significantly
influence
release
profiles
degradation
times.
This
review
also
covers
extensive
literature
on
application
PLGA
delivering
small-molecule
drugs,
proteins,
peptides,
antibiotics,
antiviral
drugs.
Furthermore,
discuss
role
PLGA-based
DDSs
treating
various
diseases,
cancer,
neurological
disorders,
pain,
inflammation.
The
incorporation
drugs
into
nanoparticles
microspheres
has
been
shown
to
enhance
their
therapeutic
efficacy,
reduce
toxicity,
improve
patient
compliance.
Overall,
holds
great
promise
for
advancement
treatment
management
multiple
chronic
conditions.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6099 - 6126
Опубликована: Июнь 1, 2024
Abstract:
The
relentless
pursuit
of
effective
cancer
diagnosis
and
treatment
strategies
has
led
to
the
rapidly
expanding
field
nanotechnology,
with
a
specific
focus
on
nanocomposites.
Nanocomposites,
combination
nanomaterials
diverse
properties,
have
emerged
as
versatile
tools
in
oncology,
offering
multifunctional
platforms
for
targeted
delivery,
imaging,
therapeutic
interventions.
Nanocomposites
exhibit
great
potential
early
detection
accurate
imaging
diagnosis.
Integrating
various
modalities,
such
magnetic
resonance
(MRI),
computed
tomography
(CT),
fluorescence
into
nanocomposites
enables
development
contrast
agents
enhanced
sensitivity
specificity.
Moreover,
functionalizing
targeting
ligands
ensures
selective
accumulation
tumor
tissues,
facilitating
precise
diagnostic
accuracy.
On
front,
revolutionized
by
overcoming
traditional
challenges
associated
drug
delivery.
controlled
release
from
nanocomposite
carriers
enhances
bioavailability,
reduces
systemic
toxicity,
improves
overall
efficacy.
Additionally,
integration
stimuli-responsive
components
within
site-specific
triggered
unique
microenvironment
tumor.
Despite
remarkable
progress
field,
biocompatibility,
scalability,
long-term
safety
profiles
remain.
This
article
provides
comprehensive
overview
recent
developments,
challenges,
prospects,
emphasizing
transformative
revolutionizing
landscape
diagnostics
therapeutics.
In
Conclusion,
integrating
heralds
new
era
precision
medicine.
Keywords:
nanocomposites,
cancer,
diagnosis,
therapy,
nanoparticles,
theranostic
Journal of Cellular Physiology,
Год журнала:
2020,
Номер
235(12), С. 9241 - 9268
Опубликована: Июнь 9, 2020
Abstract
Lung
cancer
is
a
main
cause
of
death
all
over
the
world
with
high
incidence
rate.
Metastasis
into
neighboring
and
distant
tissues
as
well
resistance
cells
to
chemotherapy
demand
novel
strategies
in
lung
therapy.
Curcumin
naturally
occurring
nutraceutical
compound
derived
from
Curcuma
longa
(turmeric)
that
has
great
pharmacological
effects,
such
anti‐inflammatory,
neuroprotective,
antidiabetic.
The
excellent
antitumor
activity
curcumin
led
its
extensive
application
treatment
various
cancers.
In
present
review,
we
describe
against
cancer.
affects
different
molecular
pathways
vascular
endothelial
growth
factors,
nuclear
factor‐κB
(NF‐κB),
mammalian
target
rapamycin,
PI3/Akt,
microRNAs,
long
noncoding
RNAs
also
can
induce
autophagy,
apoptosis,
cell
cycle
arrest
reduce
viability
proliferation
cells.
Notably,
supplementation
sensitizes
enhances
chemotherapy‐mediated
apoptosis.
elevate
efficacy
radiotherapy
therapy
by
targeting
signaling
pathways,
epidermal
factor
receptor
NF‐κB.
Curcumin‐loaded
nanocarriers
enhance
bioavailability,
cellular
uptake,
curcumin.
aforementioned
effects
are
comprehensively
discussed
current
review
further
direct
studies
for
applying
Advanced Therapeutics,
Год журнала:
2020,
Номер
3(8)
Опубликована: Май 27, 2020
Abstract
Bacterial
resistance
to
antibiotics
is
an
important
issue
in
contemporary
society.
To
date,
infection‐related
problems
persist
despite
intensive
research
efforts
by
chemists
and
biologists.
Much
effort
has
been
devoted
over
the
last
decade
development
of
organic/nonmetallic
inorganic
nanocompounds
with
antimicrobial
activities
for
overcoming
human
infections
illnesses
produced
antibiotic‐resistant
pathogens.
Both
organic
nanomaterials
such
as
chitosan
nanoparticles
conductive‐based
polymer
nanocompounds,
well
nonmetallic
carbon‐based
modified
nanoceramics,
have
manufactured
employed
medicine
treating
multidrug‐resistant
infections.
This
review
describes
most
recent
advances
biomedical
applications
antibacterial
nanocompounds.
