Опубликована: Дек. 4, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 26, 2025
Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract
Язык: Английский
Процитировано
5
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Янв. 22, 2025
Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.
Язык: Английский
Процитировано
2
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Abstract The pioneering work on liposomes in the 1960s and subsequent research controlled drug release systems significantly advances development of nanocarriers (NCs) for delivery. This field is evolved to include a diverse array such as liposomes, polymeric nanoparticles, dendrimers, more, each tailored specific therapeutic applications. Despite significant achievements, clinical translation limited, primarily due low efficiency delivery an incomplete understanding nanocarrier interactions with biological systems. Addressing these challenges requires interdisciplinary collaboration deep nano‐bio interface. To enhance design, scientists employ both physics‐based data‐driven models. Physics‐based models provide detailed insights into chemical reactions at atomic molecular scales, while leverage machine learning analyze large datasets uncover hidden mechanisms. integration presents harmonizing different modeling approaches ensuring model validation generalization across However, this crucial developing effective targeted By integrating enhanced data infrastructure, explainable AI, computational advances, potentials, researchers can develop innovative nanomedicine solutions, ultimately improving outcomes.
Язык: Английский
Процитировано
7
Journal of Molecular Structure, Год журнала: 2024, Номер 1306, С. 137842 - 137842
Опубликована: Фев. 20, 2024
Язык: Английский
Процитировано
6
CNS & Neurological Disorders - Drug Targets, Год журнала: 2024, Номер 23(10), С. 1251 - 1262
Опубликована: Фев. 14, 2024
Abstract: The potential of nanotechnology in advancing the diagnosis and treatment neurodegenerative diseases is explored this comprehensive literature review. findings these studies suggest that has capacity to improve existing therapeutic approaches, create novel safe compounds, develop more precise imaging techniques diagnostic methods for diseases. With emergence nanomedicine era, a new innovative approach diagnosing treating conditions been introduced. Notably, researchers' development nanocarrier drug delivery tool demonstrates immense compared conventional therapy, as it maximizes efficacy minimizes undesirable side effects.
Язык: Английский
Процитировано
5
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
5
ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 2966 - 2981
Опубликована: Июль 31, 2024
Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.
Язык: Английский
Процитировано
5
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
4
Zeitschrift für Naturforschung C, Год журнала: 2025, Номер unknown
Опубликована: Фев. 8, 2025
Abstract Biogenic selenium nanoparticles (SeNPs) have emerged as promising area of research due to their unique properties and potential multifaceted applications. The biosynthesis SeNPs through biological methods, such using microorganism, plant extracts, etc., offers a safe, eco-friendly, biocompatible approach, compared traditional chemical synthesis. Recent several studies demonstrated that application includes broad antibacterial, anticancer, antioxidant, antiviral, anti-inflammatory, antidiabetic, excellent wound healing activity. On the other hand, also shown in sensing inorganic toxic metals, electrochemistry, agro-industries, aqua-cultures, fabrication solar panels. Additionally, capability enhance efficacy antibiotics act effective agents against multidrug-resistant pathogens has addressing critical health challenges. Although, exhibit wide applicability, toxicity Se, particularly its various oxidative states, necessitates careful assessment environmental impacts associated with use. Therefore, understanding balance between beneficial risks is crucial for safe This review focuses exclusively on synthesized via eco-friendly process, excluding utilizing synthesis processes. Moreover, this aims offer an overview diverse applications, risks, stability requirement, cytocompatibility opportunities SeNPs. Ultimately, bridges gap knowledge by providing updated details applications
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Selenium nanoparticles (SeNPs) exhibit significant potential in biomedical applications due to their antimicrobial, anticancer, and anti-inflammatory properties. In this study, we synthesized biocompatible SeNPs employed confocal Raman microspectroscopy map distribution within human dermal fibroblast (HDF) cells. possess a distinctive band placed outside the cellular fingerprint region, which facilitates its detection precise imaging. Viability assays revealed that cytotoxic effects only at highest concentrations for long exposure times while resulting no harmful during all of other treatments. For first time, achieved three-dimensional (3D) mapping cells, providing insights into penetration. Additionally, two-dimensional (2D) performed different sublethal demonstrated dynamic uptake confirmed internalization. These findings highlight effectiveness imaging therapeutic applications, offering an additional approach studying nanoparticle–cell interactions.
Язык: Английский
Процитировано
0