Green procedures for synthesizing potential hNMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a superparamagnetic Fe₃O₄@APTMS@Cp₂ZrCl_{x (x = 0, 1, 2)} nanocatalyst

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In this research, we have developed diverse strategies for synthesizing potential h NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a mesoporous zirconocene-containing nanocatalyst.

Язык: Английский

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Widely Targeted Metabolomics Reveals the Bioactive Metabolites and Antioxidant Activities of Chinese Yam (Dioscorea opposita Thunb.) Peel

Biomedical Chromatography, Год журнала: 2025, Номер 39(5)

Опубликована: Апрель 10, 2025

ABSTRACT Chinese yam ( Dioscorea opposita Thunb. cv. Tiegun) has been utilized in traditional medicine and as a food source for centuries. However, the metabolite profiles antioxidant activities of by‐product peel have not studied sufficiently. Thus, to effectively identify active metabolites peel, we employed UHPLC–MS/MS‐based widely targeted metabolomics on from loessial soil (LPCY) sandy (SPCY). A total 1054 were identified, comprising 379 primary metabolites, 528 secondary 147 other compounds. Notably, multivariate analyses revealed presence 143 differentially accumulated (DAMs) between SPCY LPCY. Linoleic acid metabolism, phenylpropanoid biosynthesis, plant hormone signal transduction, pyruvate sphingolipid metabolism main regulated pathways. The DPPH, ABTS, FRAP assays demonstrated that LPCY significantly higher than those SPCY. Correlation analysis most DAMs, including phenolic acids, lipids, organic amino exhibited significant positive correlations with r ≥ 0.7, p < 0.05). These results indicate promotes accumulation antioxidant‐active Overall, this study suggests peels hold potential rich natural bioactive substances.

Язык: Английский

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Potential Therapeutic Effects of Ferula gummosa Boiss. Extract on Autistic-like Behaviors in Maternally Separated Mice: Role of NMDA receptor gene

Heliyon, Год журнала: 2025, Номер unknown, С. e42957 - e42957

Опубликована: Фев. 1, 2025

Язык: Английский

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The effect of supplemental LED lighting in the range of UV, blue, and red wavelengths at different ratios on the accumulation of phenolic compounds in pak choi and swiss chard

Food Research International, Год журнала: 2024, Номер 200, С. 115438 - 115438

Опубликована: Дек. 3, 2024

Phenolic compounds are known for their health-promoting effects on humans. Pak choi (Brassica rapa ssp. chinensis) and Swiss chard (Beta vulgaris subsp. vulgaris) used here as model plants, they eaten raw baby leaf lettuce differ in phenolic compound profile while showing similar morphology. In a greenhouse an artificial light source with UV-B (215 mW m

Язык: Английский

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Assessment of sinapic acid’s protective effects against ethanol-induced gastric ulcers in rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Язык: Английский

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