Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma

Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975

Опубликована: Авг. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Язык: Английский

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Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics

Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 4 - 4

Опубликована: Янв. 31, 2025

Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.

Язык: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Год журнала: 2025, Номер 17(4), С. 701 - 701

Опубликована: Фев. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Язык: Английский

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Composite Nanoarchitectonics Towards Method for Everything in Materials Science

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2024, Номер 34(7), С. 2926 - 2947

Опубликована: Апрель 16, 2024

Abstract The characteristic feature of a biofunctional system is that components with various functions work together. These multi-components are not simply mixed together, but rationally arranged. fundamental technologies to do this in an artificial include the synthetic chemistry substances make component unit, science and techniques for assembling them, technology analyzing their nanoostructures. A new concept, nanoarchitectonics, can play role. Nanoarchitectonics post-nanotechnology concept involves building functional materials reflect nanostructures. In particular, approach combining multiple types create composite area where nanoarchitectonics be powerful tool. This review summarizes such examples related studies. presented areas catalyst & photocatalyst, energy, sensing environment, bio medical, other applications illustrate potential wide range applications. order show stages development, only state-of-the-art, also those successful developments existing research. Finally, summary brief discussion future challenges will given. applicable all aims establish ultimate methodology science.

Язык: Английский

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Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Язык: Английский

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Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma

Journal of Nanoparticle Research, Год журнала: 2024, Номер 26(8)

Опубликована: Авг. 1, 2024

Abstract Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains highly challenging due to its invasive nature, limited treatment effectiveness, and short median survival durations. Standard of care includes surgery, radiation, chemotherapy, treating fields; however, there has been little improvement rates. Biomimetic nanoparticles (NPs), coated with cell membranes endogenous components, have immense potential for improving chemotherapy GBM, by imitating cellular architecture eluding immune clearance. With more individualized efficient drug delivery, immunotherapeutic approaches biomimetic NPs may increase patient This article summarizes main research on GBM therapy, focusing classification, mechanisms, advantages, challenges, along advancements development vaccines.

Язык: Английский

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Bioengineering chitosan–antibody/fluorescent quantum dot nanoconjugates for targeted immunotheranostics of non-hodgkin B-cell lymphomas

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139515 - 139515

Опубликована: Янв. 5, 2025

Язык: Английский

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Biogenic nanoparticles: Understanding their potential role in cancer theranostics

Next Nanotechnology, Год журнала: 2025, Номер 8, С. 100149 - 100149

Опубликована: Янв. 1, 2025

Язык: Английский

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Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Glioblastoma (GBM) is an aggressive and fatal tumor. The infiltrative spread of GBM cells hinders gross total resection. residual are significantly associated with survival recurrence. Therefore, a theranostic method that can enhance the contrast between normal astrocyte (AS) selectively eradicate highly desired. In this report, both cultured in same microplate well to imitate coexistence environment treated Raman tags functionalized by anti-EGFR. Compared AS cells, show 25% higher emission, their cell death rate increases factor 2. These results demonstrate potential for selective eradication guided robust signals after primary surgery.

Язык: Английский

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Bioengineering stimuli-responsive organic-inorganic nanoarchitetures based on carboxymethylcellulose-poly-l-lysine nanoplexes: Unlocking the potential for bioimaging and multimodal chemodynamic-magnetothermal therapy of brain cancer cells

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 138985 - 138985

Опубликована: Дек. 19, 2024

Язык: Английский

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