Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2, P. 100016 - 100016
Published: March 1, 2024
Liver
damage
resulting
from
the
administration
of
various
allopathic
drugs
and
their
associated
toxicity
has
become
a
major
health
problem,
leading
to
hepatic
fibrosis,
cirrhosis,
metabolic
disorders.
This
epidemic
condition
liver
disease
represents
global
cause
death
morbidity.
Although
orthotopic
transplantation
remains
vital
treatment
option
for
fibrotic
conditions,
its
efficacy
is
limited
by
organ
scarcity
risk
immunological
rejection.
Consequently,
alternative
therapeutic
approaches
are
urgently
needed.
Cell-based
therapy
utilizing
mesenchymal
stem
cells
(MSCs)
garnered
considerable
interest
as
promising
modality.
MSCs
exhibit
immunomodulatory
properties
can
differentiate
into
hepatocytes,
thus
facilitating
regeneration
damaged
hepatocytes
increasing
residual
hepatocyte
proliferation
while
inhibiting
activation
or
apoptosis
stellate
cells.
However,
despite
potential
benefits,
transplanted
often
low
survival
rates
due
inadequate
oxidative
inflammatory
stress
resistance.
Plants
harbor
diverse
array
bioactive
compounds
known
possess
hepatoprotective
antioxidant
properties.
Nanomaterials
play
crucial
role
in
regenerative
medicine
providing
targeted
delivery
agents
scaffolds
tissue
engineering.
In
treating
liver,
nanomaterials
help
mitigate
fibrosis
progression
promote
through
controlled
release
anti-fibrotic
growth
factors.
review
highlights
synergistic
cell-based
therapy,
natural
antioxidants,
differentiation
factors,
nanotechnology
combating
advancing
medicine.
These
combined
offer
avenues
effectively
conditions
promoting
regeneration.
Journal of Nanotheranostics,
Journal Year:
2025,
Volume and Issue:
6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(4), P. 701 - 701
Published: Feb. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Cancers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2975 - 2975
Published: Aug. 27, 2024
Malignant
gliomas
present
great
difficulties
in
treatment,
with
little
change
over
the
past
30
years
median
survival
time
of
15
months.
Current
treatment
options
include
surgery,
radiotherapy
(RT),
and
chemotherapy.
New
therapies
aimed
at
suppressing
formation
new
vasculature
(antiangiogenic
treatments)
or
destroying
formed
tumor
(vascular
disrupting
agents)
show
promise.
This
study
summarizes
existing
knowledge
regarding
processes
by
which
glioblastoma
(GBM)
tumors
acquire
resistance
to
antiangiogenic
treatments.
The
discussion
encompasses
activation
redundant
proangiogenic
pathways,
heightened
cell
invasion
metastasis,
induced
hypoxia,
creation
vascular
mimicry
channels,
regulation
immune
microenvironment.
Subsequently,
we
explore
potential
strategies
overcome
this
resistance,
such
as
combining
other
methods,
personalizing
treatments
for
each
patient,
focusing
on
therapeutic
targets,
incorporating
immunotherapy,
utilizing
drug
delivery
systems
based
nanoparticles.
Additionally,
would
like
discuss
limitations
methods
future
directions
enhance
beneficial
effects
patients
GBM.
Therefore,
review
aims
research
outcome
GBM
provide
a
more
promising
opportunity
thoroughly
exploring
mechanisms
investigating
novel
strategies.
Journal of Inorganic and Organometallic Polymers and Materials,
Journal Year:
2024,
Volume and Issue:
34(7), P. 2926 - 2947
Published: April 16, 2024
Abstract
The
characteristic
feature
of
a
biofunctional
system
is
that
components
with
various
functions
work
together.
These
multi-components
are
not
simply
mixed
together,
but
rationally
arranged.
fundamental
technologies
to
do
this
in
an
artificial
include
the
synthetic
chemistry
substances
make
component
unit,
science
and
techniques
for
assembling
them,
technology
analyzing
their
nanoostructures.
A
new
concept,
nanoarchitectonics,
can
play
role.
Nanoarchitectonics
post-nanotechnology
concept
involves
building
functional
materials
reflect
nanostructures.
In
particular,
approach
combining
multiple
types
create
composite
area
where
nanoarchitectonics
be
powerful
tool.
This
review
summarizes
such
examples
related
studies.
presented
areas
catalyst
&
photocatalyst,
energy,
sensing
environment,
bio
medical,
other
applications
illustrate
potential
wide
range
applications.
order
show
stages
development,
only
state-of-the-art,
also
those
successful
developments
existing
research.
Finally,
summary
brief
discussion
future
challenges
will
given.
applicable
all
aims
establish
ultimate
methodology
science.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Among
various
cancer
treatment
methods,
photodynamic
therapy
has
received
significant
attention
due
to
its
non-invasiveness
and
high
efficiency
in
inhibiting
tumour
growth.
Recently,
specific
organelle
targeting
photosensitizers
have
increasing
interest
their
precise
accumulation
ability
trigger
organelle-mediated
cell
death
signalling
pathways,
which
greatly
reduces
the
drug
dosage,
minimizes
toxicity,
avoids
multidrug
resistance,
prevents
recurrence.
In
this
review,
recent
advances
representative
used
targeted
on
organelles,
specifically
including
endoplasmic
reticulum,
Golgi
apparatus,
mitochondria,
nucleus,
lysosomes,
been
comprehensively
reviewed
with
a
focus
structure
pathways.
Furthermore,
perspective
future
research
potential
challenges
precision
presented
at
end.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Glioblastoma
(GBM)
is
an
aggressive
and
fatal
tumor.
The
infiltrative
spread
of
GBM
cells
hinders
gross
total
resection.
residual
are
significantly
associated
with
survival
recurrence.
Therefore,
a
theranostic
method
that
can
enhance
the
contrast
between
normal
astrocyte
(AS)
selectively
eradicate
highly
desired.
In
this
report,
both
cultured
in
same
microplate
well
to
imitate
coexistence
environment
treated
Raman
tags
functionalized
by
anti-EGFR.
Compared
AS
cells,
show
25%
higher
emission,
their
cell
death
rate
increases
factor
2.
These
results
demonstrate
potential
for
selective
eradication
guided
robust
signals
after
primary
surgery.
Journal of Nanoparticle Research,
Journal Year:
2024,
Volume and Issue:
26(8)
Published: Aug. 1, 2024
Abstract
Glioblastoma
(GBM),
the
most
prevalent
primary
brain
tumor
in
adults,
remains
highly
challenging
due
to
its
invasive
nature,
limited
treatment
effectiveness,
and
short
median
survival
durations.
Standard
of
care
includes
surgery,
radiation,
chemotherapy,
treating
fields;
however,
there
has
been
little
improvement
rates.
Biomimetic
nanoparticles
(NPs),
coated
with
cell
membranes
endogenous
components,
have
immense
potential
for
improving
chemotherapy
GBM,
by
imitating
cellular
architecture
eluding
immune
clearance.
With
more
individualized
efficient
drug
delivery,
immunotherapeutic
approaches
biomimetic
NPs
may
increase
patient
This
article
summarizes
main
research
on
GBM
therapy,
focusing
classification,
mechanisms,
advantages,
challenges,
along
advancements
development
vaccines.
