A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment DOI
Fangyuan Shuai, Yijia Yin,

Yufei Yao

и другие.

Biomaterials, Год журнала: 2024, Номер 316, С. 123024 - 123024

Опубликована: Дек. 16, 2024

Язык: Английский

Development of an injectable salicylic acid–choline eutectic hydrogel for enhanced treatment of periodontitis DOI
Jin Zhang, Lingzhuang Meng,

Yinan Jia

и другие.

Materials Horizons, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Periodontitis, a chronic inflammatory disease triggered by dental plaque, often presents challenges in management, particularly severe cases where mechanical debridement alone may be insufficient. As result, adjunctive therapies, localized drug delivery systems with both antimicrobial and anti-inflammatory properties, are essential to enhance the efficacy of periodontitis management. In this study, we developed multifunctional hydrogel incorporating salicylic acid-choline deep eutectic solvent (DES) into chitosan/β-glycerol phosphate sodium (CS/GP) matrix for treatment periodontitis. The DES-CS/GP demonstrated favorable physicochemical including gelation injectability, making it highly suitable application oral cavity. effectively inhibited growth key periodontal pathogens, Porphyromonas gingivalis Fusobacterium nucleatum, significantly downregulated expression pro-inflammatory cytokines TNF-α IL-1β vitro. Cytocompatibility assessments showed over 80% cell viability human gingival fibroblasts, epithelial cells, keratinocytes 5 days treated DES-CS/GP, fluorescence microscopy confirming robust cytoskeletal integrity. Furthermore, enhanced permeability through tissues rat model periodontitis, mitigated bone loss, reduced bacterial loads P. g, suppressed tissues. These findings underscore hydrogel's potential as safe effective therapy offering combination antimicrobial, anti-inflammatory, tissue-permeating properties high biosafety ease application.

Язык: Английский

Процитировано

0
Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics DOI Creative Commons
Md. Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta

и другие.

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2645 - 2645

Опубликована: Ноя. 19, 2024

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management

Язык: Английский

Процитировано

2
Edible thermosensitive chitosan/hydroxypropyl β-cyclodextrin hydrogel with natural licoricidin for enhancing oral health: Biofilm disruption and demineralization prevention DOI

Yishan Li,

Yaqian Li,

Huiling Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136647 - 136647

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
Evaluation of gum odina/carbopol composite mucoadhesive hydrogel on pharmaceutical performance: Focusing on potential periodontal treatment DOI

Sohini Chatterjee,

Abhishek Mohanta,

Arnab De

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138708 - 138708

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions DOI
Reena Das,

Nisha Suryawanshi,

Nishant Burnase

и другие.

Dental Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Tailored modulation of reactive oxygen species and anti-inflammatory responses in periodontitis using in situ diselenium-crosslinked chitosan hydrogel DOI

Yanxian Wu,

Can Chen, Shijun Lu

и другие.

Nano Today, Год журнала: 2024, Номер 61, С. 102588 - 102588

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

0
A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment DOI
Fangyuan Shuai, Yijia Yin,

Yufei Yao

и другие.

Biomaterials, Год журнала: 2024, Номер 316, С. 123024 - 123024

Опубликована: Дек. 16, 2024

Язык: Английский

Процитировано

0