A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment DOI
Fangyuan Shuai, Yijia Yin,

Yufei Yao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123024 - 123024

Published: Dec. 16, 2024

Language: Английский

Development of an injectable salicylic acid–choline eutectic hydrogel for enhanced treatment of periodontitis DOI
Jin Zhang, Lingzhuang Meng,

Yinan Jia

et al.

Materials Horizons, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Periodontitis, a chronic inflammatory disease triggered by dental plaque, often presents challenges in management, particularly severe cases where mechanical debridement alone may be insufficient. As result, adjunctive therapies, localized drug delivery systems with both antimicrobial and anti-inflammatory properties, are essential to enhance the efficacy of periodontitis management. In this study, we developed multifunctional hydrogel incorporating salicylic acid-choline deep eutectic solvent (DES) into chitosan/β-glycerol phosphate sodium (CS/GP) matrix for treatment periodontitis. The DES-CS/GP demonstrated favorable physicochemical including gelation injectability, making it highly suitable application oral cavity. effectively inhibited growth key periodontal pathogens, Porphyromonas gingivalis Fusobacterium nucleatum, significantly downregulated expression pro-inflammatory cytokines TNF-α IL-1β vitro. Cytocompatibility assessments showed over 80% cell viability human gingival fibroblasts, epithelial cells, keratinocytes 5 days treated DES-CS/GP, fluorescence microscopy confirming robust cytoskeletal integrity. Furthermore, enhanced permeability through tissues rat model periodontitis, mitigated bone loss, reduced bacterial loads P. g, suppressed tissues. These findings underscore hydrogel's potential as safe effective therapy offering combination antimicrobial, anti-inflammatory, tissue-permeating properties high biosafety ease application.

Language: Английский

Citations

0
Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics DOI Creative Commons
Md. Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2645 - 2645

Published: Nov. 19, 2024

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management

Language: Английский

Citations

2
Edible thermosensitive chitosan/hydroxypropyl β-cyclodextrin hydrogel with natural licoricidin for enhancing oral health: Biofilm disruption and demineralization prevention DOI

Yishan Li,

Yaqian Li,

Huiling Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136647 - 136647

Published: Oct. 1, 2024

Language: Английский

Citations

1
Evaluation of gum odina/carbopol composite mucoadhesive hydrogel on pharmaceutical performance: Focusing on potential periodontal treatment DOI

Sohini Chatterjee,

Abhishek Mohanta,

Arnab De

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138708 - 138708

Published: Dec. 1, 2024

Language: Английский

Citations

1
Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions DOI
Reena Das,

Nisha Suryawanshi,

Nishant Burnase

et al.

Dental Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Tailored modulation of reactive oxygen species and anti-inflammatory responses in periodontitis using in situ diselenium-crosslinked chitosan hydrogel DOI

Yanxian Wu,

Can Chen, Shijun Lu

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102588 - 102588

Published: Dec. 6, 2024

Language: Английский

Citations

0
A nucleoside-based supramolecular hydrogel integrating localized self-delivery and immunomodulation for periodontitis treatment DOI
Fangyuan Shuai, Yijia Yin,

Yufei Yao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123024 - 123024

Published: Dec. 16, 2024

Language: Английский

Citations

0