The Preparation of Shikonin-Based Nanomedicine with Robust Gsh-Responsiveness DOI
Zhiyuan Liu, Rui Sun,

Yaxuan Huang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Convertible Hydrogel Injection Sequentially Regulates Diabetic Periodontitis DOI
Jinmin Zhou, Houxuan Li, Shuhong Li

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Diabetes exacerbates periodontitis by overexpressing reactive oxygen species (ROS), which leads to periodontal bone resorption. Consequently, it is imperative relieve inflammation and promote alveolar regeneration comprehensively for the development of diabetic treatment strategies. Furthermore, an orderly avoid interference between these two processes can achieve optimal therapeutic effect. Thus, we constructed a sequential sustained release system based on zeolitic imidazolate framework-8 (ZIF-8)-modified chitosan thermosensitive hydrogel (TOOTH) therapy in this work. Chemically modified tetracycline-3 (CMT-3) platelet-derived growth factor-BB (PDGF-BB) were loaded ZIF-8 release, respectively, with aim reducing facilitating tissue regeneration. During therapy, CMT-3 first escaped from due degradation diffusion ROS elimination. Subsequently, was dissociated under acid microenvironment, PDGF-BB sustainably released osteogenesis. The intervals could be regulated sizes ZIF-8. biocompatible TOOTH exhibited favorable effect vitro vivo. sequentially controlled facilitated holds promise promoting offers potential clinical translation.

Язык: Английский

Процитировано

0
Chitosan-based immunomodulatory bioadhesive hydrogel promotes liver hemostasis and repair DOI

Wenxin Wang,

Haochen Yao, Jie Xia

и другие.

Carbohydrate Polymers, Год журнала: 2025, Номер 353, С. 123268 - 123268

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

0
Boron-doped silica/chitosan-based elastic three-dimensional sponge scaffold for bone regeneration DOI
Lei Zheng, Chunchun Li, Zhengchao Yuan

и другие.

Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123491 - 123491

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation DOI Creative Commons
Eva M. Pålsson‐McDermott, Luke O'neill

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Язык: Английский

Процитировано

0
The preparation of shikonin-based nanomedicine with robust GSH-responsiveness DOI

Zhiyuan Liu,

Rui Sun,

Yaxuan Huang

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 705, С. 135557 - 135557

Опубликована: Окт. 13, 2024

Язык: Английский

Процитировано

1
The Preparation of Shikonin-Based Nanomedicine with Robust Gsh-Responsiveness DOI
Zhiyuan Liu, Rui Sun,

Yaxuan Huang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0