The Preparation of Shikonin-Based Nanomedicine with Robust Gsh-Responsiveness DOI
Zhiyuan Liu, Rui Sun,

Yaxuan Huang

et al.

Published: Jan. 1, 2024

Language: Английский

Convertible Hydrogel Injection Sequentially Regulates Diabetic Periodontitis DOI
Jinmin Zhou, Houxuan Li, Shuhong Li

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Diabetes exacerbates periodontitis by overexpressing reactive oxygen species (ROS), which leads to periodontal bone resorption. Consequently, it is imperative relieve inflammation and promote alveolar regeneration comprehensively for the development of diabetic treatment strategies. Furthermore, an orderly avoid interference between these two processes can achieve optimal therapeutic effect. Thus, we constructed a sequential sustained release system based on zeolitic imidazolate framework-8 (ZIF-8)-modified chitosan thermosensitive hydrogel (TOOTH) therapy in this work. Chemically modified tetracycline-3 (CMT-3) platelet-derived growth factor-BB (PDGF-BB) were loaded ZIF-8 release, respectively, with aim reducing facilitating tissue regeneration. During therapy, CMT-3 first escaped from due degradation diffusion ROS elimination. Subsequently, was dissociated under acid microenvironment, PDGF-BB sustainably released osteogenesis. The intervals could be regulated sizes ZIF-8. biocompatible TOOTH exhibited favorable effect vitro vivo. sequentially controlled facilitated holds promise promoting offers potential clinical translation.

Language: Английский

Citations

0
Chitosan-based immunomodulatory bioadhesive hydrogel promotes liver hemostasis and repair DOI

Wenxin Wang,

Haochen Yao, Jie Xia

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123268 - 123268

Published: Jan. 14, 2025

Language: Английский

Citations

0
Boron-doped silica/chitosan-based elastic three-dimensional sponge scaffold for bone regeneration DOI
Lei Zheng, Chunchun Li, Zhengchao Yuan

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123491 - 123491

Published: March 1, 2025

Language: Английский

Citations

0
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation DOI Creative Commons
Eva M. Pålsson‐McDermott, Luke O'neill

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Language: Английский

Citations

0
The preparation of shikonin-based nanomedicine with robust GSH-responsiveness DOI

Zhiyuan Liu,

Rui Sun,

Yaxuan Huang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 705, P. 135557 - 135557

Published: Oct. 13, 2024

Language: Английский

Citations

1
The Preparation of Shikonin-Based Nanomedicine with Robust Gsh-Responsiveness DOI
Zhiyuan Liu, Rui Sun,

Yaxuan Huang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0