Catalytic Enantioselective Electrophilic Difunctionalization of Unsaturated Sulfones DOI

Xinru Xu,

Tian Qin, Nan Huang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(21), С. 4514 - 4519

Опубликована: Май 17, 2024

An efficient protocol of enantioselective thiolative azidation sulfone-tethered alkenes via a chiral chalcogenide catalyzed electrophilic reaction is disclosed. A series enantioenriched sulfones bearing remote stereogenic centers was achieved with good yields and high enantioselectivities linear unsaturated cyclic sulfones. Mechanistic studies revealed the importance sulfone group in improvement reactivity enantioselectivity reaction.

Язык: Английский

Transition-Metal-Catalyzed Regiodivergent Sulfonylation of Aziridrines for the Synthesis of β‑Amino Sulfones DOI

Qinqiong Zeng,

Yujia Gong,

X. He

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(22), С. 6340 - 6346

Опубликована: Янв. 1, 2024

We developed the first transition-metal-catalyzed, regiodivergent sulfonylation of aziridines, enabling efficient synthesis diverse β-amino sulfones under mild conditions with broad substrate compatibility and high regioselectivity.

Язык: Английский

Процитировано

3
Generation of (E)-β-trifluoromethyl vinylsulfonohydrazides under photocatalysis and their anti-bacteria activity DOI
Xinhua Wang, Wei Zhou,

Wenlin Xie

и другие.

Chinese Chemical Letters, Год журнала: 2022, Номер 34(6), С. 107984 - 107984

Опубликована: Ноя. 5, 2022

Язык: Английский

Процитировано

16
Enantioselective Intermolecular Radical Amidation and Amination of Benzylic C−H Bonds via Dual Copper and Photocatalysis DOI Creative Commons
Xuemeng Chen, Zhong Lian, Søren Kramer

и другие.

Angewandte Chemie, Год журнала: 2023, Номер 135(13)

Опубликована: Фев. 1, 2023

Abstract A method for direct access to enantioenriched benzylic amides and carbamate‐protected primary benzylamines by C−H functionalization is reported. The substrate used as limiting reagent with only a small excess of the unactivated amide or carbamate nucleophile. enantioselective intermolecular dehydrogenative C−N bond formation enabled combination chiral copper catalyst, photocatalyst, an oxidant, it takes place under mild conditions, which allow broad scope. compatible late‐stage functionalization, provides easy 15 N‐labeled amines starting from cheap NH 4 Cl.

Язык: Английский

Процитировано

9
Catalyst-free photoinduced radical sulfonylation/cyclization of unactivated alkenes toward sulfone-containing quinazolinones DOI
Siyuan Chen,

Ying-Shan Wang,

Xian Han

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 11(4), С. 1169 - 1174

Опубликована: Дек. 29, 2023

A catalyst-free, photoinduced three-component reaction involving sulfur dioxide insertion/sulfonyl radical addition to an unactivated CC double bond/Minisci-type cyclization sequence has been developed access sulfonated quinazolinones.

Язык: Английский

Процитировано

8
Catalytic Enantioselective Electrophilic Difunctionalization of Unsaturated Sulfones DOI

Xinru Xu,

Tian Qin, Nan Huang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(21), С. 4514 - 4519

Опубликована: Май 17, 2024

An efficient protocol of enantioselective thiolative azidation sulfone-tethered alkenes via a chiral chalcogenide catalyzed electrophilic reaction is disclosed. A series enantioenriched sulfones bearing remote stereogenic centers was achieved with good yields and high enantioselectivities linear unsaturated cyclic sulfones. Mechanistic studies revealed the importance sulfone group in improvement reactivity enantioselectivity reaction.

Язык: Английский

Процитировано

2