Catalytic Enantioselective Electrophilic Difunctionalization of Unsaturated Sulfones DOI

Xinru Xu,

Tian Qin, Nan Huang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(21), P. 4514 - 4519

Published: May 17, 2024

An efficient protocol of enantioselective thiolative azidation sulfone-tethered alkenes via a chiral chalcogenide catalyzed electrophilic reaction is disclosed. A series enantioenriched sulfones bearing remote stereogenic centers was achieved with good yields and high enantioselectivities linear unsaturated cyclic sulfones. Mechanistic studies revealed the importance sulfone group in improvement reactivity enantioselectivity reaction.

Language: Английский

Transition-Metal-Catalyzed Regiodivergent Sulfonylation of Aziridrines for the Synthesis of β‑Amino Sulfones DOI

Qinqiong Zeng,

Yujia Gong,

X. He

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(22), P. 6340 - 6346

Published: Jan. 1, 2024

We developed the first transition-metal-catalyzed, regiodivergent sulfonylation of aziridines, enabling efficient synthesis diverse β-amino sulfones under mild conditions with broad substrate compatibility and high regioselectivity.

Language: Английский

Citations

3
Generation of (E)-β-trifluoromethyl vinylsulfonohydrazides under photocatalysis and their anti-bacteria activity DOI
Xinhua Wang, Wei Zhou,

Wenlin Xie

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(6), P. 107984 - 107984

Published: Nov. 5, 2022

Language: Английский

Citations

16
Enantioselective Intermolecular Radical Amidation and Amination of Benzylic C−H Bonds via Dual Copper and Photocatalysis DOI Creative Commons
Xuemeng Chen, Zhong Lian, Søren Kramer

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 135(13)

Published: Feb. 1, 2023

Abstract A method for direct access to enantioenriched benzylic amides and carbamate‐protected primary benzylamines by C−H functionalization is reported. The substrate used as limiting reagent with only a small excess of the unactivated amide or carbamate nucleophile. enantioselective intermolecular dehydrogenative C−N bond formation enabled combination chiral copper catalyst, photocatalyst, an oxidant, it takes place under mild conditions, which allow broad scope. compatible late‐stage functionalization, provides easy 15 N‐labeled amines starting from cheap NH 4 Cl.

Language: Английский

Citations

9
Catalyst-free photoinduced radical sulfonylation/cyclization of unactivated alkenes toward sulfone-containing quinazolinones DOI
Siyuan Chen,

Ying-Shan Wang,

Xian Han

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 11(4), P. 1169 - 1174

Published: Dec. 29, 2023

A catalyst-free, photoinduced three-component reaction involving sulfur dioxide insertion/sulfonyl radical addition to an unactivated CC double bond/Minisci-type cyclization sequence has been developed access sulfonated quinazolinones.

Language: Английский

Citations

8
Catalytic Enantioselective Electrophilic Difunctionalization of Unsaturated Sulfones DOI

Xinru Xu,

Tian Qin, Nan Huang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(21), P. 4514 - 4519

Published: May 17, 2024

An efficient protocol of enantioselective thiolative azidation sulfone-tethered alkenes via a chiral chalcogenide catalyzed electrophilic reaction is disclosed. A series enantioenriched sulfones bearing remote stereogenic centers was achieved with good yields and high enantioselectivities linear unsaturated cyclic sulfones. Mechanistic studies revealed the importance sulfone group in improvement reactivity enantioselectivity reaction.

Language: Английский

Citations

2