Carbene‐Catalyzed and Pnictogen Bond‐Assisted Access to PIII‐Stereogenic Compounds
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(28)
Опубликована: Апрель 26, 2024
Intermolecular
pnictogen
bonding
(PnB)
catalysis
has
received
increased
interest
in
non-covalent
organocatalysis.
It
been
demonstrated
that
organic
electron-deficient
atoms
can
act
as
prospective
Lewis
acids.
Here,
we
present
a
catalytic
approach
for
the
asymmetric
synthesis
of
chiral
P
Язык: Английский
Cobalt-catalyzed enantioselective hydroetherification of alkenes and symmetric 1,3-diketones
Chem Catalysis,
Год журнала:
2024,
Номер
unknown, С. 101126 - 101126
Опубликована: Окт. 1, 2024
Язык: Английский
Rhodium-Catalyzed Tandem Asymmetric Allylic Decarboxylative Addition and Cyclization of Vinylethylene Carbonates with N-nosylimines
Опубликована: Янв. 25, 2024
A
enantioselective
tandem
transformation
concerning
asymmetric
allylic
decarboxylative
addition
and
cyclization
of
N-nosylimines
with
vinylethylene
carbonates
(VECs)
in
the
presence
[Rh(C2H4)2Cl]2,
chiral
sulfoxide-N-olefin
tridentate
ligand
has
been
developed.
The
reaction
VECs
various
substituted
proceeded
smoothly
under
mild
conditions,
giving
highly
functionalized
oxazolidine
frameworks
good
to
high
yields
excellent
enantioselectivity.
Язык: Английский
Rhodium-Catalyzed Tandem Asymmetric Allylic Decarboxylative Addition and Cyclization of Vinylethylene Carbonates with N-Nosylimines
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1019 - 1019
Опубликована: Фев. 26, 2024
A
enantioselective
tandem
transformation,
concerning
asymmetric
allylic
decarboxylative
addition
and
cyclization
of
Язык: Английский
COAP/Pd-catalyzed asymmetric linear allylic alkylation for synthesizing chiral 3,3′-disubstituted oxindoles bearing all-carbon quaternary stereocenters and primary allylic alcohol structures
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5196 - 5201
Опубликована: Янв. 1, 2024
A
linear
asymmetric
allylic
alkylation
of
vinyloxirane
catalyzed
by
a
chiral
oxalamide–phosphine
(COAP)/Pd(0)
complex
was
reported.
Various
3,3′-oxindole
derivatives
were
achieved
in
good
yields
with
excellent
regio-
and
enantioselectivity.
Язык: Английский
Cobalt-Catalyzed Enantioselective Reductive Addition of Ketimine with Cyclopropyl Chloride to Construct the Chiral Amino Esters Bearing Cyclopropyl Fragments
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6311 - 6318
Опубликована: Янв. 1, 2024
Co-catalyzed
asymmetric
reductive
addition
of
ketimine
with
cyclopropyl
chloride
has
been
realized
to
access
diverse
chiral
amino
esters
bearing
fragments
broad
functional
group
tolerance
and
excellent
enantioselectivities.
Язык: Английский
Carbene‐Catalyzed and Pnictogen Bond‐Assisted Access to PIII‐Stereogenic Compounds
Angewandte Chemie,
Год журнала:
2024,
Номер
136(28)
Опубликована: Апрель 26, 2024
Abstract
Intermolecular
pnictogen
bonding
(PnB)
catalysis
has
received
increased
interest
in
non‐covalent
organocatalysis.
It
been
demonstrated
that
organic
electron‐deficient
atoms
can
act
as
prospective
Lewis
acids.
Here,
we
present
a
catalytic
approach
for
the
asymmetric
synthesis
of
chiral
P
III
compounds
by
combining
intramolecular
PnB
interactions
and
carbene
catalysis.
Our
design
features
pre‐chiral
phosphorus
molecule
bearing
two
electron‐withdrawing
benzoyl
groups,
resulting
formation
σ‐hole
at
atom.
X‐ray
interaction
(NCI)
analysis
indicate
model
substrates
exhibit
intrinsic
between
oxygen
atom
formyl
group
This
induces
conformational
locking
effect,
leading
to
crystallization
substrate
preferred
conformation
(
2
1
group).
Under
N
–heterocyclic
carbene,
aldehyde
moiety
activated
bond
selectively
reacts
with
an
alcohol
yield
corresponding
monoester/phosphorus
product
excellent
enantioselectivity.
acidic
center,
aroused
non‐polarized
interaction,
assists
selective
regulations,
providing
unique
opportunities
beyond.
Язык: Английский