Compared
with
flat
aromatic
scaffolds,
three-dimensional
aliphatic
ring
systems
feature
high
structural
complexity
and
topological
diversity
and,
thus,
have
received
increasing
attention
in
drug
discovery.
Herein,
we
describe
a
mild
general
electrochemical
method
for
the
modular
synthesis
of
structurally
distinct
cyclic
compounds,
including
monocyclic
alkanes,
benzo-fused
systems,
spirocycles,
from
readily
available
alkenes
alkyl
halides
via
radical–polar
crossover
mechanism.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(23), С. 8106 - 8125
Опубликована: Янв. 1, 2023
This
tutorial
review
delves
into
the
unique
advantages
of
electrochemistry
in
context
asymmetric
catalysis,
first
providing
a
brief
introduction
to
electrosynthesis,
then
exploring
representative
case
studies
with
mechanistic
focus.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(31), С. 16966 - 16972
Опубликована: Июль 27, 2023
We
present
a
new,
unified
approach
for
the
transformation
of
benzylic
and
allylic
alcohols,
aldehydes,
ketones
into
boronic
esters
under
electroreductive
conditions.
Key
to
our
strategy
is
use
readily
available
pinacolborane,
which
serves
both
as
an
activator
electrophile
by
first
generating
redox-active
trialkylborate
species
then
delivering
desired
deoxygenatively
borylated
product.
This
applicable
variety
substrates
can
be
employed
late-stage
functionalization
complex
molecules.
Organic Letters,
Год журнала:
2024,
Номер
26(21), С. 4427 - 4432
Опубликована: Май 17, 2024
2,3-Diaryl
propanoic
acids
are
important
structures
as
a
result
of
their
widespread
presence
in
numerous
bioactive
compounds.
However,
the
limitations
existing
synthetic
techniques
include
requirement
for
costly
catalysts
and
limited
substrates.
Here,
we
developed
novel
electroreductive
arylcarboxylation
alkenes
with
CO2
based
on
radical–polar
crossover
pathway
assisted
by
easily
accessible
dimethyl
terephthalate
reductive
mediator.
This
method
will
provide
an
efficient
strategy
synthesis
2,3-diarylpropanoic
acids.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2382 - 2431
Опубликована: Апрель 12, 2024
Abstract
This
contribution
offers
a
comprehensive
overview
of
methods
for
forging
sp
C−Si
bonds.
Over
time,
alkynylsilanes
(silylacetylenes),
once
considered
mere
byproducts
hydrosilylation
processes,
have
become
essential
building
blocks
in
organic
synthesis.
literature
review
traces
the
evolution
their
synthesis,
from
traditional
methodologies
relying
on
organolithium
and
organomagnesium
compounds
to
more
advanced
cross‐coupling
reactions
involving
hydro‐
carbosilanes.
Focused
primarily
past
25
years
(2000–2024),
it
also
extensively
references
significant
historical
breakthroughs.
By
analyzing
synthetic
methodologies,
not
only
survey
current
state
knowledge
but
identifies
areas
improvement.
Furthermore,
emphasize
importance
1‐alkynylsilanes
(1‐silyl‐1‐alkynes),
selected
applications
these
are
highlighted,
confirming
potential
Chemical Science,
Год журнала:
2024,
Номер
15(16), С. 5814 - 5831
Опубликована: Янв. 1, 2024
Sacrificial
anodes
enable
reductive
electrosynthesis
but
can
inadvertently
limit
the
conditions
compatible
with
organic
reactions.
Addressing
challenges
that
arise
at
sacrificial
improve
yields
and
streamline
reaction
optimization.
