Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)

Organic Process Research & Development, Год журнала: 2024, Номер 28(2), С. 338 - 366

Опубликована: Янв. 18, 2024

This review summarizes examples of organic electrosynthesis from the peer-reviewed literature 2000 to 2023 that have been conducted on scales 20 g or above. A significant portion these were a ≤100 scale, while detailed reports kilogram-scale remain scarce in pharmaceutical industry. In addition chemical transformation, this also highlights type reactor used and projected productivity metric as ways compare different reports. The selected scale-ups described herein illustrate remaining challenges currently preventing routine use large-scale

Язык: Английский

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Recent Advances in Electrochemical Carboxylation with CO₂

Accounts of Chemical Research, Год журнала: 2024, Номер 57(18), С. 2728 - 2745

Опубликована: Сен. 3, 2024

ConspectusCarbon dioxide (CO

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Recent advances in oxidative degradation of plastics

Chemical Society Reviews, Год журнала: 2024, Номер 53(14), С. 7309 - 7327

Опубликована: Янв. 1, 2024

Oxidative degradation is a powerful method to degrade plastics into oligomers and small oxidized products. While thermal energy has been conventionally employed as an external stimulus, recent advances in photochemistry have enabled photocatalytic oxidative of polymers under mild conditions. This tutorial review presents overview degradation, from its earliest examples emerging strategies. briefly discusses the motivation development with focus on underlying mechanisms. Then, we will examine modern studies primarily relevant catalytic degradation. Lastly, highlight some unique using unconventional approaches for polymer such electrochemistry.

Язык: Английский

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Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey

Organic Process Research & Development, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

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Cobaltaelectro‐Catalyzed C–H Activation for Central and Axial Double Enantio‐Induction

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(31)

Опубликована: Май 17, 2024

In recent years, enantioselective electrocatalysis has surfaced as an increasingly-effective platform for sustainable molecular synthesis. Despite indisputable progress, strategies that allow the control of two distinct stereogenic elements with high selectivity remain elusive. contrast, we, herein, describe electrochemical cobalt-catalyzed C-H activations enable installation chiral centers along a axis levels enantio- and diastereoselectivities. The developed strategy allowed C-H/N-H activations/annulations cyclic non-cyclic alkenes providing expedient access to various central well atropo-chiral dihydroisoquinolinones paired valuable hydrogen evolution reaction. Studies on atropo-stability obtained compounds demonstrated exceedingly mild conditions ensured by electrocatalytic process were key achieved stereoselectivities.

Язык: Английский

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Allylgermane synthesis via facile and general nickela-electrocatalyzed electrophile coupling

Chem Catalysis, Год журнала: 2025, Номер unknown, С. 101257 - 101257

Опубликована: Фев. 1, 2025

Язык: Английский

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Manganese-Catalyzed Electrochemical Oxidation of Tryptophan-Containing Peptides and Indole Derivatives by O₂

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 3928 - 3939

Опубликована: Фев. 20, 2025

Язык: Английский

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Synthesis of Non-C₂-Symmetric Biaryldiols via Organo-Electro Catalyzed Aryl–Aryl Dehydrogenative Cross-Coupling

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7524 - 7532

Опубликована: Фев. 19, 2025

Despite a few successful examples, controlling the enantioselectivity in asymmetric synthesis of non-C2-symmetric biaryldiols has long been challenging. To address issues and regioselectivity, we introduced novel organoelectrocatalytic strategy enabling aryl-aryl dehydrogenative cross-coupling reactions. Using this approach, valuable were obtained up to 95% yields 97% enantiomeric excesses (ees), these compounds could be further applied as versatile ligands Detailed mechanistic studies supported sequential diradical followed by central-to-axial chirality conversion pathway.

Язык: Английский

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Parametrization of κ²-N,O-Oxazoline Preligands for Enantioselective Cobaltaelectro-Catalyzed C–H Activations

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 4450 - 4459

Опубликована: Фев. 28, 2025

Enantioselective electrocatalyzed C–H activations have emerged as a transformative platform for the assembly of value-added chiral organic molecules. Despite recent progress, construction multiple C(sp3)-stereogenic centers via C(sp3)–C(sp3) bond formation has thus far proven to be elusive. In contrast, we herein report an annulative activation strategy, generating Fsp3-rich molecules with high levels diastereo- and enantioselectivity. κ2-N,O-oxazoline preligands were effectively employed in enantioselective cobalt(III)-catalyzed reactions. Using DFT-derived descriptors regression statistical modeling, performed parametrization study on modularity preligands. The resulted model describing ligands' selectivity characterized by key steric, electronic, interaction behaviors.

Язык: Английский

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Enantioselective C–H annulations enabled by either nickel- or cobalt-electrocatalysed C–H activation for catalyst-controlled chemodivergence

Nature Catalysis, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

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