Molecules,
Год журнала:
2019,
Номер
24(5), С. 830 - 830
Опубликована: Фев. 26, 2019
Weinreb
amides
are
a
privileged,
multi-functional
group
with
well-established
utility
in
classical
synthesis.
Recently,
several
studies
have
demonstrated
the
use
of
as
interesting
substrates
transition
metal-catalyzed
C-H
functionalization
reactions.
Herein,
we
review
this
part
literature,
including
metal
catalysts,
transformations
explored
so
far
and
specific
insights
from
mechanistic
studies.
ACS Catalysis,
Год журнала:
2022,
Номер
12(23), С. 14754 - 14772
Опубликована: Ноя. 18, 2022
Carboamination
of
readily
available
feedstock-like
alkenes,
alkynes,
and
allenes
has
proven
to
be
an
efficient
powerful
tool
for
the
synthesis
diverse
valuable
amine
derivatives
relevance
medicinal
chemistry,
biochemistry,
material
science.
Among
these
developed
carboamination
methodologies,
direct
use
C–H
activation
strategy
leverage
process
is
particularly
attractive
due
ubiquity
such
bonds
in
organic
molecules.
In
this
review,
we
provide
overview
development
intermolecular
across
C–C
π-bonds
initiated
by
a
redox-neutral
nonannulative
manner,
with
emphasis
on
synthetic
mechanistic
aspects.
principle,
review
summarized
reactions
key
feature
involving
initial
metalation
followed
migratory
insertion
into
terminated
electrophilic
amination
quenching,
thus,
it
ordered
sources
C-
N-based
functionalities
further
divided
π-compounds.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6359 - 6378
Опубликована: Янв. 1, 2023
This
review
discusses
the
important
role
of
silver(
i
)
salts
as
additives
in
transition-metal
catalyzed
C–H
activation,
and
depicts
discussion
about
current
shift
towards
Ag-free
procedures,
plausible
sustainable
alternatives.
ACS Catalysis,
Год журнала:
2023,
Номер
13(8), С. 5127 - 5134
Опубликована: Март 30, 2023
The
rhodium-catalyzed
enantioselective
C–H
iodination
of
1-aryl
isoquinolines
under
mild
conditions
is
disclosed.
Direct
with
N-iodosuccinimide
(NIS)
catalyzed
by
chiral
CpRh(III)
complexes
afforded
a
series
axially
biaryl
iodides
in
excellent
yields
and
enantioselectivity
(up
to
99%
yield
97%
ee).
Furthermore,
the
atroposelective
bromination
chlorination
reactions
were
also
compatible.
Notably,
could
be
easily
transformed
QUINAP-type
N,N-type
ligands.
The
utilization
of
high-valent
metal
catalysts
to
promote
cycloaddition
reactions
involving
π
bonds
through
C-C
bond
activation
remains
challenging.
Despite
extensive
research,
the
aldehydes
with
cyclopropenones
catalyzed
by
complexes
has
not
been
documented.
Herein,
we
disclose
a
novel
Rh(III)-catalyzed
reaction
between
and
aldehydes,
enabling
efficient
synthesis
highly
functionalized
furanones.
A
detailed
mechanistic
investigation
was
conducted,
revealing
likely
involvement
tripodal
Rh-carbene
intermediate
in
catalytic
cycle,
which
facilitates
product
release
pathway.
This
exhibits
broad
substrate
scope,
good
functional
group
compatibility,
high
atom
economy,
thereby
offering
versatile
general
approach
construction
Molecules,
Год журнала:
2019,
Номер
24(5), С. 830 - 830
Опубликована: Фев. 26, 2019
Weinreb
amides
are
a
privileged,
multi-functional
group
with
well-established
utility
in
classical
synthesis.
Recently,
several
studies
have
demonstrated
the
use
of
as
interesting
substrates
transition
metal-catalyzed
C-H
functionalization
reactions.
Herein,
we
review
this
part
literature,
including
metal
catalysts,
transformations
explored
so
far
and
specific
insights
from
mechanistic
studies.