Molecules, Год журнала: 2019, Номер 24(5), С. 830 - 830
Опубликована: Фев. 26, 2019
Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of as interesting substrates transition metal-catalyzed C-H functionalization reactions. Herein, we review this part literature, including metal catalysts, transformations explored so far and specific insights from mechanistic studies.
Язык: Английский
ACS Catalysis, Год журнала: 2022, Номер 12(23), С. 14754 - 14772
Опубликована: Ноя. 18, 2022
Carboamination of readily available feedstock-like alkenes, alkynes, and allenes has proven to be an efficient powerful tool for the synthesis diverse valuable amine derivatives relevance medicinal chemistry, biochemistry, material science. Among these developed carboamination methodologies, direct use C–H activation strategy leverage process is particularly attractive due ubiquity such bonds in organic molecules. In this review, we provide overview development intermolecular across C–C π-bonds initiated by a redox-neutral nonannulative manner, with emphasis on synthetic mechanistic aspects. principle, review summarized reactions key feature involving initial metalation followed migratory insertion into terminated electrophilic amination quenching, thus, it ordered sources C- N-based functionalities further divided π-compounds.
Язык: Английский
Процитировано
30
Chemical Society Reviews, Год журнала: 2023, Номер 52(18), С. 6359 - 6378
Опубликована: Янв. 1, 2023
This review discusses the important role of silver( i ) salts as additives in transition-metal catalyzed C–H activation, and depicts discussion about current shift towards Ag-free procedures, plausible sustainable alternatives.
Язык: Английский
Процитировано
23
ACS Catalysis, Год журнала: 2023, Номер 13(8), С. 5127 - 5134
Опубликована: Март 30, 2023
The rhodium-catalyzed enantioselective C–H iodination of 1-aryl isoquinolines under mild conditions is disclosed. Direct with N-iodosuccinimide (NIS) catalyzed by chiral CpRh(III) complexes afforded a series axially biaryl iodides in excellent yields and enantioselectivity (up to 99% yield 97% ee). Furthermore, the atroposelective bromination chlorination reactions were also compatible. Notably, could be easily transformed QUINAP-type N,N-type ligands.
Язык: Английский
Процитировано
21
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
The utilization of high-valent metal catalysts to promote cycloaddition reactions involving π bonds through C-C bond activation remains challenging. Despite extensive research, the aldehydes with cyclopropenones catalyzed by complexes has not been documented. Herein, we disclose a novel Rh(III)-catalyzed reaction between and aldehydes, enabling efficient synthesis highly functionalized furanones. A detailed mechanistic investigation was conducted, revealing likely involvement tripodal Rh-carbene intermediate in catalytic cycle, which facilitates product release pathway. This exhibits broad substrate scope, good functional group compatibility, high atom economy, thereby offering versatile general approach construction
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2019, Номер 24(5), С. 830 - 830
Опубликована: Фев. 26, 2019
Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of as interesting substrates transition metal-catalyzed C-H functionalization reactions. Herein, we review this part literature, including metal catalysts, transformations explored so far and specific insights from mechanistic studies.
Язык: Английский
Процитировано
50