Organic Letters,
Год журнала:
2020,
Номер
22(18), С. 7152 - 7157
Опубликована: Авг. 28, 2020
The
redox-neutral
Ir(III)-
or
Ru(II)-catalyzed
C–H
couplings
of
azomethine
imines
with
α,α-difluoromethylene
alkynes
have
been
realized,
leading
to
the
efficient
synthesis
indenopyrazole
frameworks
via
a
tandem
functionalization/[3
+
2]
dipolar
cycloaddition/ring-opening
aromatization
rearrangement
process,
in
which
generated
fluoroallene
species
was
involved
as
dipolarophile
selective
β-F
elimination
process.
Subsequent
biological
evaluation
revealed
that
these
synthesized
indenopyrazoles
could
serve
interesting
cytotoxic
agents
for
further
development.
Chemical Communications,
Год журнала:
2021,
Номер
57(30), С. 3692 - 3695
Опубликована: Янв. 1, 2021
An
efficient
synthesis
of
substituted
3,4-dihydroisoquinolinones
through
[4+2]-annulation
N-chlorobenzamides/acrylamides
with
alkylidenecyclopropanes
using
a
less
expensive
and
air
stable
Co(iii)
catalyst
is
demonstrated.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(47), С. 21437 - 21442
Опубликована: Ноя. 15, 2022
We
report
the
first
examples
of
use
a
new
class
ligands
(NOBINAc)
for
performing
asymmetric
C-H
activations
using
palladium
catalysts.
These
combine
axial
chirality
binaphthyl
scaffolds
with
bifunctional
and
bidentate
coordination
properties
mono-N-protected
amino
acids
(MPAAs),
which
are
well-known
to
favor
Pd-promoted
via
concerted
metalation-deprotonation
mechanisms.
demonstrate
that
our
enable
substantially
higher
enantioselectivities
than
MPAAs
in
assembly
2-benzazepines
through
formal
(5
+
2)
cycloadditions
between
homobenzyltriflamides
or
o-methylbenzyltriflamides
allenes.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(4), С. 1015 - 1021
Опубликована: Янв. 1, 2023
Presented
herein
is
a
divergent
synthesis
of
indene-fused
pyrazoles
and
bridged
benzodiazepines
tethered
with
hydroxymethyl
group
through
the
cascade
reactions
aryl
azomethine
imines
vinyl
cyclic
carbonates.
Chemical Communications,
Год журнала:
2024,
Номер
60(31), С. 4246 - 4249
Опубликована: Янв. 1, 2024
Herein,
an
electrochemical
approach
toward
the
ring
opening
functionalization
of
methylenecyclopropanes
(MCPs)
via
C–C
bond
cleavage
in
presence
alcohols
is
reported.
Organic Letters,
Год журнала:
2020,
Номер
22(18), С. 7152 - 7157
Опубликована: Авг. 28, 2020
The
redox-neutral
Ir(III)-
or
Ru(II)-catalyzed
C–H
couplings
of
azomethine
imines
with
α,α-difluoromethylene
alkynes
have
been
realized,
leading
to
the
efficient
synthesis
indenopyrazole
frameworks
via
a
tandem
functionalization/[3
+
2]
dipolar
cycloaddition/ring-opening
aromatization
rearrangement
process,
in
which
generated
fluoroallene
species
was
involved
as
dipolarophile
selective
β-F
elimination
process.
Subsequent
biological
evaluation
revealed
that
these
synthesized
indenopyrazoles
could
serve
interesting
cytotoxic
agents
for
further
development.
