Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(9), С. 1294 - 1315
Опубликована: Дек. 13, 2024
The
serotoninergic
system
plays
an
essential
role
in
the
modulation
of
spinal
networks
activity
involved
control
motor,
sensory,
and
visceral
functions.
Spinal
cord
injury
(SCI)
can
induce
a
state
overexcitation
that
contributes
to
pain,
spasticity,
dysregulation
autonomic
At
same
time,
5-NT
axons
are
known
adapt
faster
than
others
pathophysiologic
changes
leave
ability
sprout
regenerate
after
injury.
A
number
experimental
animal
studies
as
well
some
clinical
observations
suggest
is
key
endogenous
resource
for
posttraumatic
recovery
SCI.
Specific
therapy
may
include
administration
drugs
intraspinal
transplantation
neurons.
This
review
discusses
functional
SCI
prospects
use
neurorehabilitation.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(13), С. 5160 - 5169
Опубликована: Март 12, 2024
Matrix-assisted
laser
desorption/ionization
mass
spectrometry
imaging
(MALDI-MSI),
which
is
a
label-free
technique,
determines
the
spatial
distribution
and
relative
abundance
of
versatile
endogenous
metabolites
in
tissues.
Meanwhile,
matrix
selection
generally
regarded
as
pivotal
step
MALDI
tissue
imaging.
This
study
presents
first
report
novel
matrix,
2-hydroxy-5-nitro-3-(trifluoromethyl)pyridine
(HNTP),
for
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(8), С. 1702 - 1711
Опубликована: Март 4, 2024
Serotonin-releasing
fibers
depart
from
the
raphe
nuclei
to
profusely
innervate
entire
central
nervous
system,
displaying
in
some
brain
regions
high
structural
plasticity
response
genetically
induced
abrogation
of
serotonin
synthesis.
Chronic
fluoxetine
treatment
used
as
a
tool
model
peri-physiological,
clinically
relevant
elevation
is
also
able
cause
rearrangements
serotonergic
innervating
hippocampus.
Whether
this
effect
limited
hippocampal-innervating
or
extends
other
populations
axons
not
known.
Here,
we
confocal
imaging
and
three-dimensional
(3-D)
modeling
analysis
expand
our
morphological
investigation
fluoxetine-mediated
effects
on
circuitry.
We
found
that
chronic
with
behaviorally
active
dose
affects
morphology
reduces
density
medial
prefrontal
cortex,
region
strongly
implicated
regulation
depressive-
anxiety-like
behavior.
Axons
somatosensory
cortex
were
unaffected,
suggesting
differential
susceptibility
changes
across
cortical
areas.
Importantly,
1-month
washout
period
was
sufficient
reverse
both
previously
characterized
hippocampus,
well
normalize
behavior,
highlighting
an
intriguing
relationship
between
axon
antidepressant-like
effect.
Overall,
these
results
further
demonstrate
bidirectional
defined
provide
additional
insights
into
system.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6475 - 6475
Опубликована: Июнь 12, 2024
Physiology
and
behavior
are
structured
temporally
to
anticipate
daily
cycles
of
light
dark,
ensuring
fitness
survival.
Neuromodulatory
systems
in
the
brain—including
those
involving
serotonin
dopamine—exhibit
oscillations
neural
activity
help
shape
circadian
rhythms.
Disrupted
neuromodulation
can
cause
abnormalities
that
thought
underlie
several
neuropsychiatric
disorders,
including
bipolar
mania
schizophrenia,
for
which
a
mechanistic
understanding
is
still
lacking.
Here,
we
show
genetically
depleting
Tph2
knockout
mice
promotes
manic-like
behaviors
disrupts
dopamine
biosynthetic
enzyme
tyrosine
hydroxylase
(TH)
midbrain
dopaminergic
nuclei.
Specifically,
while
TH
mRNA
protein
levels
Substantia
Nigra
(SN)
Ventral
Tegmental
Area
(VTA)
wild-type
doubled
between
dark
phase,
were
high
throughout
day
mice,
suggesting
hyperdopaminergic
state.
Analysis
expression
striatal
terminal
fields
also
showed
blunted
Additionally,
found
low
abundance
rhythmicity
neuropeptide
cholecystokinin
(Cck)
VTA
whose
downregulation
has
been
implicated
states
both
rodents
humans.
Altogether,
our
results
point
previously
unappreciated
serotonergic
control
signaling
propose
dysfunction
as
an
upstream
mechanism
underlying
deregulation
ultimately
maladaptive
behaviors.
Serotonin
is
one
of
the
most
potent
gastrointestinal,
peripheral,
and
neuronal
signaling
molecules
plays
a
key
role
in
regulating
energy
metabolism.
Accumulating
evidence
has
shown
complex
interplay
between
gut
microbiota
host
In
this
review,
we
summarize
recent
findings
on
serotonin
metabolism
discuss
complicated
mechanisms
by
which
serotonin,
working
conjunction
with
microbiota,
affects
total
body
host.
Gut
synthesis,
storage,
release,
transport,
catabolism.
addition,
an
indispensable
homeostasis
through
organ
crosstalk
microbe-host
communication,
particularly
wide
array
serotonergic
effects
mediated
diverse
receptors
unique
tissue
specificity.
This
fresh
perspective
will
help
broaden
understanding
modulating
metabolism,
thus
shedding
light
design
innovative
serotonin-targeting
strategies
to
treat
metabolic
diseases.
Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
18
Опубликована: Янв. 6, 2025
The
evolution
of
brain-expressed
genes
is
notably
slower
than
that
expressed
in
other
tissues,
a
phenomenon
likely
due
to
high-level
functional
constraints.
One
such
constraint
might
be
the
integration
information
by
neuron
assemblies,
enhancing
environmental
adaptability.
This
study
explores
physiological
mechanisms
neurons
through
three
types
synchronization:
chemical,
electromagnetic,
and
quantum.
Chemical
synchronization
involves
diffuse
release
neurotransmitters
like
dopamine
acetylcholine,
causing
transmission
delays
several
milliseconds.
Electromagnetic
encompasses
action
potentials,
electrical
gap
junctions,
ephaptic
coupling.
Electrical
junctions
enable
rapid
within
cortical
GABAergic
networks,
while
coupling
allows
structures
axon
bundles
synchronize
extracellular
electromagnetic
fields,
surpassing
speed
chemical
processes.
Quantum
hypothesized
involve
ion
coherence
during
channel
passage
entanglement
photons
myelin
sheath.
Unlike
finite-time
seen
processes,
quantum
provides
instantaneous
non-local
states.
Neurons
have
evolved
from
diffusion
temporal
synchronization,
with
networks
potentially
facilitating
both
fast
gamma
band
coherence.
mini-review
compiles
literature
on
these
types,
offering
new
insights
into
address
binding
problem
assemblies.
Cells,
Год журнала:
2025,
Номер
14(7), С. 545 - 545
Опубликована: Апрель 4, 2025
Aging
involves
progressive
physiological
changes,
including
the
dysregulation
of
water
homeostasis,
essential
for
cellular
function,
neuronal
signaling,
and
musculoskeletal
integrity.
This
review
explores
emerging
role
loss
as
a
central
underestimated
driver
functional
decline
in
aging,
with
focus
on
dog,
both
clinically
relevant
target
species
model
human
aging.
Age-related
alterations
metabolism—driven
by
changes
body
composition,
aquaporin
(AQP)
expression,
electrolyte
imbalances,
reduced
thirst
perception,
impaired
urine
concentration—lead
to
intracellular
extracellular
dehydration,
exacerbating
decline.
We
examine
molecular
mechanisms
regulation
involving
AQPs
osmolytes,
describe
how
dehydration
contributes
structural
metabolic
dysfunction
across
key
biological
compartments,
kidney,
brain,
bone,
skeletal
muscle.
Physiological
hallmark
intensifies
inflammaging,
accelerating
tissue
degeneration.
In
particular,
we
highlight
impairs
solvent
capacity,
solute
transport,
protein
conformation,
communication.
Despite
known
macronutrients
geriatric
nutrition,
hydration
remains
an
often-overlooked
factor
aging
management.
argue
its
inclusion
fourth
pillar
nutritional
approach
veterinary
geriatrics,
alongside
protein,
fat,
fiber.
By
investigating
aging-associated
dogs—species
that
share
environments
lifestyle
patterns
humans—we
propose
hydration-centered
strategies
promote
healthy
comparative
medicine.
