Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Abstract
Medicines,
food
packaging,
personal
care
products,
and
cosmetics
extensively
use
polyethylene
terephthalate
nanoplastics
(PET-NaPs).
However,
they
also
have
harmful
impacts
on
several
organs.
Betaine
demonstrates
potent
antioxidant
anti-inflammatory
characteristics.
Our
goal
was
to
investigate
the
detrimental
impact
of
PET-NaPs
mouse
brain
evaluate
neuroprotective
properties
betaine.
We
allocated
40
completely
mature
male
Swiss
albino
mice
into
four
distinct
groups:
control
group,
betaine
betaine-co-treated
group.
Following
a
30-day
duration,
euthanasia
performed
mice,
analyzed
tissue
samples
were
obtained
from
cerebrum,
cerebellum,
hippocampus.
resulted
in
an
elevated
level
malondialdehyde
upregulated
cyclooxygenase-2
interleukin-1
beta
(IL-1β)
expression
while
significantly
reducing
levels
glutathione
downregulating
acetylcholinesterase.
The
PET-NPs
caused
significant
changes
histopathology
tissue,
there
demonstrable
rise
immunostaining
IL-1β
glial
fibrillary
acidic
proteins.
Consequently,
effectively
alleviated
negative
consequences
PET-NaPs.
Therefore,
possesses
capacity
mitigate
neurotoxic
induced
by
Язык: Английский
Neuroprotective Effects of Dendrobium nobile
CABI eBooks,
Год журнала:
2025,
Номер
unknown, С. 198 - 217
Опубликована: Март 24, 2025
Язык: Английский
Betaine: A Comprehensive Review on Dietary Sources, Health Benefits, Mechanisms of Action, and Application
Trends in Food Science & Technology,
Год журнала:
2025,
Номер
unknown, С. 104993 - 104993
Опубликована: Апрель 1, 2025
Язык: Английский
Nanoparticles induced neurotoxicity
Nanotoxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 28
Опубликована: Апрель 16, 2025
The
early
development
of
nanotechnology
has
spurred
major
interest
on
the
toxicity
nanoparticles
(NPs)
due
to
their
ability
penetrate
biological
barriers
such
as
BBB.
This
review
aims
at
addressing
how
silver
(AgNPs),
titanium
dioxide
(TiO2NPs),
zinc
oxide
(ZnONPs),
iron
(Fe3O4NPs),
carbon
NPs,
Copper
(Cu-NPs),
silicon
(SiO2
NPs)
and
quantum
dots
cause
neurotoxicity.
Some
signaling
that
occur
are
related
oxidative
stress,
neuroinflammation,
mitochondrial
dysfunction
cell
equilibrium,
hence
results
in
neuronal
damage
neurodegeneration.
It
is
critical
describe
there
multiple
ways
by
NPs
may
be
toxic
based
size
surface,
dosage,
recipient's
age
health
condition.
A
vitro
vivo
analysis
provides
information
about
potentials
preventive
measures
including
modification
NP
surface
antioxidant
treatment.
underline
necessity
comprehensive
safety
assessments
allow
further
utilization
across
economy.
Язык: Английский
Alleviative effect of betaine against copper oxide nanoparticles-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2024,
Номер
13(1)
Опубликована: Май 20, 2024
Abstract
Background
Copper
oxide
nanoparticles
(CuO-NPs)
have
gained
interest
due
to
their
availability,
efficiency,
and
cost-effectiveness.
Betaine
is
an
essential
methyl
donor
takes
part
in
various
physiological
activities
inside
the
body;
it
found
protective
curative
effects
against
liver
diseases.
The
present
study
aimed
evaluate
hepatotoxic
effect
of
CuO-NPs
on
adult
male
albino
rats
ability
betaine
alleviate
such
hepatotoxicity.
Methods
Forty
Wister
were
grouped
into
4
groups
(10
rats/group):
group
I
a
negative
control,
II
injected
with
intra
peritoneal
by
insulin
needle
(0.5
mg/kg/day),
III
(betaine
+
CuO-NPs)
administered
orally
gavage
(250
mg/kg/day
1
h
before
mg/kg/day)
finally,
IV
(betaine)
for
consecutive
28
days.
Blood
samples
gathered
processed
biochemical,
molecular,
histopathological,
immunohistochemical
investigations.
Results
Group
displayed
marked
rise
alanine
aminotransferase
(ALT),
aspartate
(AST),
malondialdehyde
(MDA)
levels.
Furthermore,
there
excessive
upregulation
inflammatory
biomarkers
interleukin1
beta
(IL-1β)
tumor
necrosis
factor-alpha
(TNF-α).
On
other
hand,
substantial
reduction
glutathione
(GSH)
levels
significant
downregulation
at
peroxidase
(GPx)
mRNA
gene
expression.
Regarding
histopathological
deviations,
severe
congestion,
dilatation
hyalinization
blood
vessels,
steatosis,
hydropic
degeneration,
hepatocytic
necrosis,
increased
binucleation,
degenerated
bile
ducts,
hyperplasia
ducts
epithelial
lining,
cells
infiltration.
Immunohistochemically,
was
pronounced
immunoreactivity
toward
IL-1β.
Luckily,
pre-administration
able
mitigate
these
changes.
MDA
dramatically
reduced,
resulting
IL-1β
TNF-α.
Additionally,
considerable
GSH
GPx.
Histopathological
deviations
substantially
improved
as
diminished
dilatation,
congestion
hepatocytes,
are
normal
some
extent.
In
addition,
analysis
revealed
decreased
intensity.
Conclusion
can
effectively
reduce
hepatotoxicity
caused
via
its
antioxidant
properties
stimulate
cell
redox
system.
Язык: Английский
Toxicology of Nanomaterials With a Special Focus on the Nervous System
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 27 - 64
Опубликована: Окт. 11, 2024
Nanomaterials
possess
different
properties
that
make
them
suitable
for
application
in
numerous
fields.
Nonetheless,
their
toxicity,
especially
neurotoxic
propensity,
is
a
considerable
area
of
investigation.
In
this
chapter,
nanomaterial
neurotoxicity
reviewed
detail,
with
an
emphasis
on
assessing
levels
exposure
or
routes
entry
to
brain
cells,
mechanisms
by
which
they
cause
damage,
and
specific
types
damage.
addition,
vitro,
ex
vivo,
vivo
models
used
measure
are
described.
This
chapter
provides
discussion
matter
considering
challenges
terms
characterization,
risk
assessment,
regulatory
aspects.
concludes
underscoring
the
importance
toxicological
prediction
safe-by-design
solutions.
Future
research
should
address
long-term
effects
using
nanomaterials
means
preventing
neurotoxicity.
Язык: Английский
Effects of Aluminum Oxide Nanoparticles in the Spinal Cord of Male Wistar Rats and the Potential Ameliorative Role of Melatonin
Environmental Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
ABSTRACT
Aluminum
oxide
nanoparticles
(Al
2
O
3
NPs)
are
widely
utilized
in
vaccine
manufacturing
and
other
medical
preparations.
Melatonin
has
numerous
effects
as
an
antioxidant
anti‐apoptotic.
The
purpose
of
this
study
was
to
examine
the
beneficial
impact
melatonin
on
Al
NPs
toxicity
spinal
cord.
Forty
male
rats
were
divided
into
four
groups:
Group
I,
negative
controls
(received
standard
diet
distilled
water);
II,
30
mg/kg
bw
NPs);
III,
+
10
melatonin);
IV,
melatonin).
All
treatments
administered
daily
for
28
days
by
gastric
gavage.
After
that,
all
sacrificed,
then,
samples
from
different
cords
subjected
histopathological,
biochemical,
immunohistochemical
analyses.
markedly
elevated
malondialdehyde
8‐hydroxydeoxyguanosine
while
inhibiting
superoxide
dismutase
catalase.
also
induced
histological
alterations
both
gray
white
matter
manifested
neuronal
degeneration,
vacuolation,
axonal
ballooning,
fusion
myelin
sheaths.
Furthermore,
results
displayed
a
strong
positive
expression
caspase‐3.
Conversely,
significantly
mitigated
increasing
activities
enzymes
8‐hydroxydeoxyguanosine.
Moreover,
alleviated
most
reduced
caspase‐3
immunoreactivity.
Collectively,
could
protect
cord
mitigate
NPs‐induced
neurotoxicity.
Язык: Английский