PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal
Tissue and Cell,
Год журнала:
2025,
Номер
93, С. 102739 - 102739
Опубликована: Янв. 14, 2025
Язык: Английский
The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options
Jiayong Yao,
Xiaohong Dai,
Xueping Yv
и другие.
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 4, 2025
Intracerebral
hemorrhage
(ICH)
is
a
non
traumatic
that
occurs
in
certain
part
of
the
brain.
It
usually
leads
to
brain
cell
damage.
According
large
number
experimental
research,
oxidative
stress
an
important
pathophysiological
processes
cerebral
hemorrhage.
In
this
paper,
we
aim
determine
how
changes
biomarkers
indicate
damage
degree
hemorrhage,
and
explore
summarize
potential
treatments
or
interventions.
We
found
patients
with
are
characterized
by
increased
levels
markers,
such
as
total
malondialdehyde
(MDA),
F2
isoprostaglandin,
hydroxynonenal,
myeloperoxidase
protein
hydroxyl.
Therefore,
caused
ICH
on
these
markers
can
be
used
evaluate
diagnose
ICH,
predict
its
prognosis,
guide
preventive
treatment
turn
antioxidant
based
new
alternative.
Язык: Английский
The Emerging Role of PCSK9 in the Pathogenesis of Alzheimer’s Disease: A Possible Target for the Disease Treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13637 - 13637
Опубликована: Дек. 20, 2024
Alzheimer’s
disease
(AD)
is
a
multifactorial
neurodegenerative
mainly
caused
by
β-amyloid
(Aβ)
accumulation
in
the
brain.
Among
several
factors
that
may
concur
to
AD
development,
elevated
cholesterol
levels
and
brain
dyshomeostasis
have
been
recognized
play
relevant
role.
Proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
protein
primarily
known
regulate
plasma
low-density
lipoproteins
(LDLs)
rich
be
one
of
main
causes
familial
hypercholesterolemia.
In
addition
that,
PCSK9
also
carry
out
diverse
important
activities
brain,
including
control
neuronal
differentiation,
apoptosis,
and,
importantly,
LDL
receptors
functionality.
Moreover,
appeared
directly
involved
some
principal
processes
responsible
for
such
as
inflammation,
oxidative
stress,
Aβ
deposition.
On
these
bases,
management
might
represent
promising
approach
treatment.
The
purpose
this
review
elucidate
role
PCSK9,
whether
or
not
cholesterol-related,
pathogenesis
give
an
updated
overview
most
innovative
therapeutic
strategies
developed
so
far
counteract
pleiotropic
both
humoral
focusing
particular
on
their
potentiality
management.
Язык: Английский
The negative linear relationship between oxidative balance scores and constipation: a cross-sectional study from NHANES 2005–2010
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 15, 2024
Background
This
study
aimed
to
investigate
the
relationship
between
oxidation
balance
score
(OBS)
and
constipation.
Methods
All
data
was
collected
from
2005–2010
cycles
of
National
health
nutrition
examination
survey
(NHANES)
database.
The
OBS
constipation
analyzed
by
logistic
regression,
restricted
cubic
spline.
Trend
analysis
used
explore
whether
there
is
a
linear
quartiles
constipation,
while
interaction
conducted
determine
other
factors
influence
Subgroup
examine
two
in
different
subgroups.
three
machine
learning
algorithms
including
Xgboost,
Randomforest,
AdaBoost
analyze
important
component
Results
A
total
8,074
participants
were
involved.
We
found
that
negative
also
existed
after
adjusting
for
all
possible
confounders.
trend
test
showed
higher
OBS,
lower
likelihood
developing
(
P
trend<0.05).
marital
status
diabetes
interact
with
on
receiver
operating
characteristic
indicated
had
good
prediction
efficiency
especially
without
married
or
living
partner.
body
mass
index
magnesium
components
related
Conclusion
Oxidation
negatively
associated
occurrence
adults.
Moreover,
Язык: Английский