Exploring the Correlation of Linker Structure and Antimicrobial Activities of Pyridinium-Based Cationic Biocides: Aromatic versus Aliphatic Architectures

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117673 - 117673

Опубликована: Апрель 1, 2025

Язык: Английский

---

Dynamic Antimicrobial Poly(disulfide) Coatings Exfoliate Biofilms On Demand Via Triggered Depolymerization

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)

Опубликована: Янв. 30, 2024

Abstract Bacterial biofilms are notoriously problematic in applications ranging from biomedical implants to ship hulls. Cationic, amphiphilic antibacterial surface coatings delay the onset of biofilm formation by killing microbes on contact, but they lose effectiveness over time due non‐specific binding biomass and formation. Harsh treatment methods required forcibly expel regenerate a clean surface. Here, simple, dynamically reversible method polymer coating that enables both chemical on‐demand mechanical delamination surface‐bound biofilms, triggered depolymerization underlying antimicrobial layer, is developed. Antimicrobial derivatives based α‐lipoic acid (LA) undergo dynamic polymerization into polydisulfides functionalized with biocidal quaternary ammonium salt groups. These kill >99.9% Staphylococcus aureus cells, repeatedly for 15 cycles without loss activity, moderate microbial challenges (≈10 5 colony‐forming units (CFU) mL −1 , 1 h), ultimately foul under intense 7 CFU days). The attached then exfoliated UV‐triggered degradation an aqueous solution at neutral pH. This work provides simple strategy can bacteria contact extended timescales, followed removal mild conditions.

Язык: Английский

---

Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures

ChemMedChem, Год журнала: 2024, Номер 19(11)

Опубликована: Фев. 28, 2024

Cationic biocides play a crucial role in the disinfection of domestic and healthcare surfaces. Due to rise bacterial resistance towards common cationic disinfectants like quaternary ammonium compounds (QACs), development novel actives is necessary for effective infection prevention control. Toward this end, series 15 chimeric biscationic amphiphilic compounds, bearing both phosphonium residues, were prepared probe structure efficacy mixed ammonium-phosphonium structures. Compounds obtained two steps good yields, with straightforward chromatography-free purifications. Antibacterial activity evaluation these against panel seven strains, including MRSA strains as well opportunistic pathogen A. baumannii, encouraging, low micromolar inhibitory was observed multiple Alkyl chain length on group was, expected, major determinant bioactivity. In addition, high therapeutic indexes (up 125-fold) triphenyl phosphonium-bearing amphiphiles when comparing antimicrobial mammalian cell lysis activity.

Язык: Английский

---

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

ACS Infectious Diseases, Год журнала: 2024, Номер 10(4), С. 1080 - 1096

Опубликована: Март 28, 2024

The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among challenges posed, biofilms stand out due to their formidable resistance conventional antibiotics. This review delves burgeoning potential pillar[n]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. is structured two main sections, each dedicated exploring distinct facets pillar[n]arene applications. first section scrutinizes functionalized pillar[n]arenes with particular emphasis on cationic derivatives. analysis reveals significant efficacy inhibiting biofilm formation, underscoring pivotal role specific chemical attributes combating microbial communities. second shifts its focus inclusion complexes, elucidating how serve encapsulation platforms for enhances stability antibiotics and enables controlled release, thereby amplifying antibacterial activity. examination complexes provides valuable insights synergy between traditional antibiotics, offering novel avenue overcoming resistance. comprehensive highlights escalating threat infections urgent need innovative strategies counteract biofilms. unique properties both molecules complex hosts, position them candidates quest effective exploration mechanisms opens new avenues research development ongoing battle against biofilm-related challenges.

Язык: Английский

---

Regulating molecular brush structure on cotton textiles for efficient antibacterial properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131486 - 131486

Опубликована: Апрель 9, 2024

Язык: Английский

---