Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
531, С. 216477 - 216477
Опубликована: Фев. 8, 2025
Язык: Английский
Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
The
rapid
emergency
and
spread
of
antimicrobial-resistant
(AMR)
bacteria
the
lack
new
antibiotics
being
developed
pose
serious
threats
to
global
healthcare
system.
Therefore,
development
more
effective
therapies
overcome
AMR
is
highly
desirable.
Metal
ions
have
a
long
history
serving
as
antimicrobial
agents,
metal-based
compounds
are
now
attracting
interest
from
scientific
communities
in
fight
against
owing
their
unique
mechanism.
Moreover,
they
may
also
serve
antibiotic
adjuvants
enhance
efficacy
clinically
used
antibiotics.
In
this
perspective,
we
highlight
important
showcase
studies
last
10
years
on
strategies
crisis.
Specifically,
categorize
these
metallo-antimicrobials
into
five
classes
based
modes
action
(i.e.,
metallo-enzymes
metal-binding
enzyme
inhibitors,
membrane
perturbants,
uptake/efflux
system
inhibitors/regulators,
persisters
oxidative
stress
inducers).
significant
advantages
over
traditional
lie
multitargeted
mechanisms,
which
render
less
likelihood
generate
resistance.
However,
notice
that
such
raise
concern
potential
side
effects
low
selectivity
toward
pathogens
host,
appears
be
biggest
obstacle
for
downstream
translational
research.
We
anticipate
combination
therapy
through
repurposing
(metallo)drugs
with
optimization
absorption
route
formulation
achieve
target-oriented
delivery
will
powerful
way
combat
AMR.
Despite
challenges,
hold
great
opportunities
therapeutic
intervention
infection
by
resistant
bacteria.
Язык: Английский
Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
524, С. 216300 - 216300
Опубликована: Ноя. 9, 2024
Язык: Английский
A phthalimide-triazole derivative obtained by click chemistry exhibits trypanocidal activity, induces autophagy and ameliorates Trypanosoma cruzi infection
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
186, С. 117963 - 117963
Опубликована: Март 17, 2025
Язык: Английский
Synthetic strategies for the incorporation of metallocenes into anti-infective scaffolds
Apollonia Kalamatianou,
Corentin Ludwig,
Shuai Zhong
и другие.
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
With
the
rates
of
infectious
diseases
and
(pan)drug-resistant
pathogens
constantly
increasing,
there
is
a
pressing
need
for
development
new
drug
candidates.
Язык: Английский