Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The rapid emergency and spread of antimicrobial-resistant (AMR) bacteria the lack new antibiotics being developed pose serious threats to global healthcare system. Therefore, development more effective therapies overcome AMR is highly desirable. Metal ions have a long history serving as antimicrobial agents, metal-based compounds are now attracting interest from scientific communities in fight against owing their unique mechanism. Moreover, they may also serve antibiotic adjuvants enhance efficacy clinically used antibiotics. In this perspective, we highlight important showcase studies last 10 years on strategies crisis. Specifically, categorize these metallo-antimicrobials into five classes based modes action (i.e., metallo-enzymes metal-binding enzyme inhibitors, membrane perturbants, uptake/efflux system inhibitors/regulators, persisters oxidative stress inducers). significant advantages over traditional lie multitargeted mechanisms, which render less likelihood generate resistance. However, notice that such raise concern potential side effects low selectivity toward pathogens host, appears be biggest obstacle for downstream translational research. We anticipate combination therapy through repurposing (metallo)drugs with optimization absorption route formulation achieve target-oriented delivery will powerful way combat AMR. Despite challenges, hold great opportunities therapeutic intervention infection by resistant bacteria.

Язык: Английский

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Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine

Coordination Chemistry Reviews, Год журнала: 2025, Номер 531, С. 216477 - 216477

Опубликована: Фев. 8, 2025

Язык: Английский

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A phthalimide-triazole derivative obtained by click chemistry exhibits trypanocidal activity, induces autophagy and ameliorates Trypanosoma cruzi infection

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 117963 - 117963

Опубликована: Март 17, 2025

Язык: Английский

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Synthetic strategies for the incorporation of metallocenes into anti-infective scaffolds

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

With the rates of infectious diseases and (pan)drug-resistant pathogens constantly increasing, there is a pressing need for development new drug candidates.

Язык: Английский

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Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine

Coordination Chemistry Reviews, Год журнала: 2024, Номер 524, С. 216300 - 216300

Опубликована: Ноя. 9, 2024

Язык: Английский

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