Cited by Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine

Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges DOI

Chenyuan Wang, Xueying Wei, Liang Zhong

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The rapid emergency and spread of antimicrobial-resistant (AMR) bacteria the lack new antibiotics being developed pose serious threats to global healthcare system. Therefore, development more effective therapies overcome AMR is highly desirable. Metal ions have a long history serving as antimicrobial agents, metal-based compounds are now attracting interest from scientific communities in fight against owing their unique mechanism. Moreover, they may also serve antibiotic adjuvants enhance efficacy clinically used antibiotics. In this perspective, we highlight important showcase studies last 10 years on strategies crisis. Specifically, categorize these metallo-antimicrobials into five classes based modes action (i.e., metallo-enzymes metal-binding enzyme inhibitors, membrane perturbants, uptake/efflux system inhibitors/regulators, persisters oxidative stress inducers). significant advantages over traditional lie multitargeted mechanisms, which render less likelihood generate resistance. However, notice that such raise concern potential side effects low selectivity toward pathogens host, appears be biggest obstacle for downstream translational research. We anticipate combination therapy through repurposing (metallo)drugs with optimization absorption route formulation achieve target-oriented delivery will powerful way combat AMR. Despite challenges, hold great opportunities therapeutic intervention infection by resistant bacteria.

Language: Английский

Citations

Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine DOI

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

Citations

A phthalimide-triazole derivative obtained by click chemistry exhibits trypanocidal activity, induces autophagy and ameliorates Trypanosoma cruzi infection DOI

Lucas Eduardo Bezerra de Lima,

Madson Q. Almeida, Gleicyane Silva Gomes

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 117963 - 117963

Published: March 17, 2025

Language: Английский

Citations

Synthetic strategies for the incorporation of metallocenes into anti-infective scaffolds DOI

Apollonia Kalamatianou,

Corentin Ludwig,

Shuai Zhong

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

With the rates of infectious diseases and (pan)drug-resistant pathogens constantly increasing, there is a pressing need for development new drug candidates.

Language: Английский

Citations

Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine DOI

Tiansheng Wang, Didier Astruc

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216300 - 216300

Published: Nov. 9, 2024

Language: Английский

Citations