Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells DOI

Chang Cao,

Wen Wang, Shuo Zhu

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Язык: Английский

Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells DOI

Chang Cao,

Wen Wang, Shuo Zhu

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Язык: Английский

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