Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells DOI

Chang Cao,

Wen Wang, Shuo Zhu

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Language: Английский

Robust Acid-Responsive AILE Luminescence Effect Nanoparticle for Drug Release Monitoring and Induction of Apoptosis in Cancer Cells DOI

Chang Cao,

Wen Wang, Shuo Zhu

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Through the PFOEP-SO3(−) + multidrug molecules constructed nanoparticle (NP) experiments and validated by molecular simulation docking experiments, we propose a interaction principle for inducing aggregation-induced locally excited emission (AILE) luminescence from fluorenone (FO)-based conjugated polymers (CPs). Based on this mechanism, NP built π–π stacking. The NPs demonstrate facile synthesis, robust stability, high drug-loading efficiency, enabling tumor-specific drug release in acidic lysosomal environments (pH 3.8–4.7) to minimize off-target toxicity. Concurrently, PFOEPA exhibit pH-dependent fluorescence enhancement: incorporation induces structural reorganization into "sandwich" configuration, amplifying with blue shift under neutral/alkaline conditions, while acidic-triggered protonation collapse disrupts NPs. Moreover, it can be used as an indicator monitoring release, is accompanied changes during process. This possesses multiple functions expected serve effective pH-responsive delivery system.

Language: Английский

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