Cell Reports Physical Science,
Год журнала:
2021,
Номер
2(5), С. 100436 - 100436
Опубликована: Май 1, 2021
Doped
semiconductor
materials
with
various
properties
are
useful
for
improving
early
diagnostics
and
therapies
in
medical
research,
which
is
essential
advanced
techniques
reducing
mortality
rates.
The
emerging
research
on
nanocrystals
doped
impurities
important.
These
dopants
can
directly
affect
electron
transport
semiconductors,
tune
the
optical
of
nanoscale
desirable
ways,
bring
some
specific
characteristics
to
hosts.
In
this
review,
we
first
discuss
factors
that
need
be
considered
systematically
control
generation
these
then
describe
a
variety
typical
synthesis
approaches
techniques.
Finally,
current
biomedical
applications
future
outlook
summarized
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(2), С. 2499 - 2528
Опубликована: Янв. 5, 2023
Lanthanide-doped
upconversion
nanoparticles
(UCNPs)
possess
the
remarkable
ability
to
convert
multiple
near-infrared
(NIR)
photons
into
higher
energy
ultraviolet-visible
(UV-vis)
photons,
making
them
a
prime
candidate
for
several
advanced
applications
within
realm
of
nanotechnology.
Compared
traditional
organic
fluorophores
and
quantum
dots
(QDs),
UCNPs
narrower
emission
bands
(fwhm
10-50
nm),
large
anti-Stokes
shifts,
low
toxicity,
high
chemical
stability,
resistance
photobleaching
blinking.
In
addition,
unlike
UV-vis
excitation,
NIR
excitation
is
nondestructive
at
lower
power
intensities
has
tissue
penetration
depths
(up
2
mm)
with
autofluorescence
scattering.
Together,
these
properties
make
exceedingly
favored
bioanalytical
theranostic
applications,
where
systems
have
been
well-explored.
are
also
well-suited
bioimaging,
optically
modulating
chemistries,
forensic
science,
other
state-of-the-art
research
applications.
this
review,
an
up-to-date
account
emerging
in
UCNP
research,
beyond
theranostics,
presented
including
optogenetics,
super-resolution
imaging,
encoded
barcodes,
fingerprinting,
vision,
UCNP-assisted
photochemical
manipulations,
optical
tweezers,
3D
printing,
lasing,
NIR-II
UCNP-molecule
nanohybrids,
UCNP-based
persistent
luminescent
nanocrystals.
ACS Applied Bio Materials,
Год журнала:
2020,
Номер
4(5), С. 3937 - 3961
Опубликована: Дек. 14, 2020
Bacterial
infection
is
a
universal
threat
to
public
health,
which
not
only
causes
many
serious
diseases
but
also
exacerbates
the
condition
of
patients
cancer,
pandemic
diseases,
e.g.,
COVID-19,
and
so
on.
Antibiotic
therapy
has
been
used
be
an
effective
way
for
common
bacterial
disinfection.
However,
due
misuse
abuse
antibiotics,
more
antibiotic-resistant
bacteria
have
emerged
as
fatal
threats
human
beings.
At
present,
than
700,000
die
every
year
with
infections
because
lack
treatment.
It
frustrating
that
pace
development
antibiotics
lags
far
behind
resistance,
estimation
10
million
deaths
per
from
after
2050.
Facing
such
rigorous
challenge,
approaches
disinfection
are
urgently
demanded.
The
recently
developed
near-infrared
(NIR)
light-irradiation-based
highly
promising
shatter
resistance
by
employing
NIR
light-responsive
materials
mediums
generate
antibacterial
factors
heat,
reactive
oxygen
species
(ROS),
This
treatment
approach
proved
potent
candidate
accurately
realize
spatiotemporal
control,
while
effectively
eradicating
multidrug-resistant
inhibiting
antibiotic
resistance.
Herein,
we
summarize
latest
progress
light-based
Ultimately,
current
challenges
perspectives
in
this
field
discussed.
Biomedicines,
Год журнала:
2021,
Номер
9(7), С. 756 - 756
Опубликована: Июнь 29, 2021
Due
to
the
unique
properties
of
lanthanide-doped
upconverting
nanoparticles
(UCNP)
under
near-infrared
(NIR)
light,
last
decade
has
shown
a
sharp
progress
in
their
biomedicine
applications.
Advances
techniques
for
polymer,
dye,
and
bio-molecule
conjugation
on
surface
further
expanded
dynamic
opportunities
optogenetics,
oncotherapy
bioimaging.
In
this
account,
considering
primary
benefits
such
as
absence
photobleaching,
photoblinking,
autofluorescence
UCNPs
not
only
facilitate
construction
accurate,
sensitive
multifunctional
nanoprobes,
but
also
improve
therapeutic
diagnostic
results.
We
introduce,
with
basic
knowledge
upconversion,
mechanisms
involved
photon
upconversion
discuss
how
can
be
implemented
biological
practices.
focused
review,
we
categorize
applications
UCNP-based
various
strategies
into
following
domains:
neuromodulation,
immunotherapy,
drug
delivery,
photodynamic
photothermal
therapy,
bioimaging
biosensing.
Herein,
current
emerging
bioapplications
cutting
edge
nano-/biointerfacing
UCNPs.
Finally,
review
provides
concluding
remarks
future
challenges
clinical
translation
UCNPs-based
nanotechnology
research.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(37)
Опубликована: Май 1, 2022
Abstract
Despite
the
significant
advancements
of
developing
upconversion
nanoparticles
(UCNPs)
for
high
performance
biosensing
and
bioimaging,
development
DNA‐functionalized
UCNPs
with
thin
coatings,
efficient
surface
passivation,
fully
functional
DNAs
hybridization
sensing
in
biological
media
remains
extremely
challenging.
Here,
a
straightforward
concept
labeling
DNA
to
polysulfonate
polymer
layer
on
is
presented.
Both
preserve
their
full
functionality
as
demonstrated
by
Förster
resonance
energy
transfer
(FRET)
assays
Cy3‐conjugated
complementary
DNA.
The
important
bioanalytical
benefits
UCNP‐DNA
nanohybrids
are
implementation
into
rapid
wash‐free
microRNA
FRET
assays.
Using
simple
fiber‐coupled
USB‐spectrometer
980
nm
diode
laser
excitation
96‐well
microplate,
ratiometric
from
UCNP‐to‐Cy3
can
quantify
miR20a
0.01–10
×
10
−9
m
concentration
range
detection
limit
30
−12
(4.5
fmol
miR20a),
which
more
than
20‐fold
lower
compared
quantum
dot‐based
thin‐coating
DNA‐UCNP
have
strong
potential
translating
advanced
DNA‐based
biosensing,
high‐throughput
point‐of‐care
clinical
diagnostics.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(18)
Опубликована: Фев. 20, 2023
Abstract
Orthogonal
upconversion
with
color‐switchable
emissions
under
different
excitation
conditions
provides
new
chances
to
diverse
frontier
applications
of
luminescent
materials.
However,
the
previous
orthogonal
systems
compulsorily
require
precise
control
spatial
distributions
dopants
and
host
compositions
avoid
spectral
cross‐talk,
greatly
limiting
their
synthesis
application.
Herein,
a
conceptual
design
is
presented
realize
by
selectively
activating
sensitizers
activators
in
nanostructure.
In
detail,
915
nm
laser,
instead
mostly
used
980
nm,
adopted
activate
sensitizer
Yb
3+
because
broad
2
F
5/2
←
7/2
absorption
band;
while
it
non‐responsive
Er
,
consequently
avoiding
cross‐talk
due
simultaneous
activation
both
irradiation
as
shown
works.
Such
selective
strategy
able
red/green,
blue/red,
blue/green
single
nanoparticle
simply
altering
wavelength
from
1530
nm.
More
interestingly,
further
allows
for
full‐color
output
temporal
dynamics.
The
findings
suggest
facile
but
effective
approach
smart
materials,
showing
great
potential
multi‐level
anti‐counterfeiting,
information
security
biological
applications.
Advanced Materials,
Год журнала:
2023,
Номер
35(42)
Опубликована: Сен. 19, 2023
Abstract
Optogenetic
modulation
of
brain
neural
activity
that
combines
optical
and
electrical
modes
in
a
unitary
system
has
recently
gained
robust
momentum.
Controlling
illumination
spatial
coverage,
designing
light‐activated
modulators,
developing
wireless
light
delivery
data
transmission
are
crucial
for
maximizing
the
use
neuromodulation.
To
this
end,
biocompatible
electrodes
with
enhanced
optoelectrical
performance,
device
integration
multiplexed
addressing,
transmission,
multimodal
operation
soft
systems
have
been
developed.
This
review
provides
an
outlook
uniformly
illuminating
large
areas
while
spatiotemporally
imaging
responses
upon
stimulation
little
artifacts.
Representative
concepts
important
breakthroughs,
such
as
head‐mounted
illumination,
multiple
implanted
fibers,
micro‐light‐delivery
devices,
discussed.
Examples
techniques
incorporate
electrophysiological
monitoring
presented.
Challenges
perspectives
posed
further
research
efforts
toward
high‐density
interface
modulation,
potential
nonpharmacological
neurological
disease
treatments
stimulation.
