Synthesis strategies and biomedical applications for doped inorganic semiconductor nanocrystals DOI Creative Commons
Xuan Peng, Fujin Ai,

Li Yan

и другие.

Cell Reports Physical Science, Год журнала: 2021, Номер 2(5), С. 100436 - 100436

Опубликована: Май 1, 2021

Doped semiconductor materials with various properties are useful for improving early diagnostics and therapies in medical research, which is essential advanced techniques reducing mortality rates. The emerging research on nanocrystals doped impurities important. These dopants can directly affect electron transport semiconductors, tune the optical of nanoscale desirable ways, bring some specific characteristics to hosts. In this review, we first discuss factors that need be considered systematically control generation these then describe a variety typical synthesis approaches techniques. Finally, current biomedical applications future outlook summarized discussed.

Язык: Английский

Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications DOI
Karan Malhotra, David A. Hrovat, Balmiki Kumar

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(2), С. 2499 - 2528

Опубликована: Янв. 5, 2023

Lanthanide-doped upconversion nanoparticles (UCNPs) possess the remarkable ability to convert multiple near-infrared (NIR) photons into higher energy ultraviolet-visible (UV-vis) photons, making them a prime candidate for several advanced applications within realm of nanotechnology. Compared traditional organic fluorophores and quantum dots (QDs), UCNPs narrower emission bands (fwhm 10-50 nm), large anti-Stokes shifts, low toxicity, high chemical stability, resistance photobleaching blinking. In addition, unlike UV-vis excitation, NIR excitation is nondestructive at lower power intensities has tissue penetration depths (up 2 mm) with autofluorescence scattering. Together, these properties make exceedingly favored bioanalytical theranostic applications, where systems have been well-explored. are also well-suited bioimaging, optically modulating chemistries, forensic science, other state-of-the-art research applications. this review, an up-to-date account emerging in UCNP research, beyond theranostics, presented including optogenetics, super-resolution imaging, encoded barcodes, fingerprinting, vision, UCNP-assisted photochemical manipulations, optical tweezers, 3D printing, lasing, NIR-II UCNP-molecule nanohybrids, UCNP-based persistent luminescent nanocrystals.

Язык: Английский

Процитировано

81

Upconverted/downshifted NaLnF4 and metal-organic framework heterostructures boosting NIR-II imaging-guided photodynamic immunotherapy toward tumors DOI

Qi-Xian Wang,

Yuanfan Yang, X. C. Yang

и другие.

Nano Today, Год журнала: 2022, Номер 43, С. 101439 - 101439

Опубликована: Март 3, 2022

Язык: Английский

Процитировано

75

Near-Infrared Light Brightens Bacterial Disinfection: Recent Progress and Perspectives DOI

Qinyu Han,

Jun Wei Lau, Thang Do Cong

и другие.

ACS Applied Bio Materials, Год журнала: 2020, Номер 4(5), С. 3937 - 3961

Опубликована: Дек. 14, 2020

Bacterial infection is a universal threat to public health, which not only causes many serious diseases but also exacerbates the condition of patients cancer, pandemic diseases, e.g., COVID-19, and so on. Antibiotic therapy has been used be an effective way for common bacterial disinfection. However, due misuse abuse antibiotics, more antibiotic-resistant bacteria have emerged as fatal threats human beings. At present, than 700,000 die every year with infections because lack treatment. It frustrating that pace development antibiotics lags far behind resistance, estimation 10 million deaths per from after 2050. Facing such rigorous challenge, approaches disinfection are urgently demanded. The recently developed near-infrared (NIR) light-irradiation-based highly promising shatter resistance by employing NIR light-responsive materials mediums generate antibacterial factors heat, reactive oxygen species (ROS), This treatment approach proved potent candidate accurately realize spatiotemporal control, while effectively eradicating multidrug-resistant inhibiting antibiotic resistance. Herein, we summarize latest progress light-based Ultimately, current challenges perspectives in this field discussed.

Язык: Английский

Процитировано

85

Optical multiplexing of upconversion in nanoparticles towards emerging applications DOI
Songbin Liu,

Zhengce An,

Bo Zhou

и другие.

Chemical Engineering Journal, Год журнала: 2022, Номер 452, С. 139649 - 139649

Опубликована: Окт. 8, 2022

Язык: Английский

Процитировано

67

Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications DOI Creative Commons
Manoj Kumar Mahata, Ranjit De, Kang Taek Lee

и другие.

Biomedicines, Год журнала: 2021, Номер 9(7), С. 756 - 756

Опубликована: Июнь 29, 2021

Due to the unique properties of lanthanide-doped upconverting nanoparticles (UCNP) under near-infrared (NIR) light, last decade has shown a sharp progress in their biomedicine applications. Advances techniques for polymer, dye, and bio-molecule conjugation on surface further expanded dynamic opportunities optogenetics, oncotherapy bioimaging. In this account, considering primary benefits such as absence photobleaching, photoblinking, autofluorescence UCNPs not only facilitate construction accurate, sensitive multifunctional nanoprobes, but also improve therapeutic diagnostic results. We introduce, with basic knowledge upconversion, mechanisms involved photon upconversion discuss how can be implemented biological practices. focused review, we categorize applications UCNP-based various strategies into following domains: neuromodulation, immunotherapy, drug delivery, photodynamic photothermal therapy, bioimaging biosensing. Herein, current emerging bioapplications cutting edge nano-/biointerfacing UCNPs. Finally, review provides concluding remarks future challenges clinical translation UCNPs-based nanotechnology research.

Язык: Английский

Процитировано

64

DNA‐Coated Upconversion Nanoparticles for Sensitive Nucleic Acid FRET Biosensing DOI Creative Commons
Laura Francés‐Soriano, Nestor Estébanez, Julia Pérez‐Prieto

и другие.

Advanced Functional Materials, Год журнала: 2022, Номер 32(37)

Опубликована: Май 1, 2022

Abstract Despite the significant advancements of developing upconversion nanoparticles (UCNPs) for high performance biosensing and bioimaging, development DNA‐functionalized UCNPs with thin coatings, efficient surface passivation, fully functional DNAs hybridization sensing in biological media remains extremely challenging. Here, a straightforward concept labeling DNA to polysulfonate polymer layer on is presented. Both preserve their full functionality as demonstrated by Förster resonance energy transfer (FRET) assays Cy3‐conjugated complementary DNA. The important bioanalytical benefits UCNP‐DNA nanohybrids are implementation into rapid wash‐free microRNA FRET assays. Using simple fiber‐coupled USB‐spectrometer 980 nm diode laser excitation 96‐well microplate, ratiometric from UCNP‐to‐Cy3 can quantify miR20a 0.01–10 × 10 −9 m concentration range detection limit 30 −12 (4.5 fmol miR20a), which more than 20‐fold lower compared quantum dot‐based thin‐coating DNA‐UCNP have strong potential translating advanced DNA‐based biosensing, high‐throughput point‐of‐care clinical diagnostics.

Язык: Английский

Процитировано

61

Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis DOI
Hengrui Zhang,

Wenya Jiang,

Yaou Peng

и другие.

Biomaterials, Год журнала: 2022, Номер 286, С. 121577 - 121577

Опубликована: Май 19, 2022

Язык: Английский

Процитировано

57

Recent progress in upconversion nanomaterials for emerging optical biological applications DOI
Hao Chen, Binbin Ding,

Ping’an Ma

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 188, С. 114414 - 114414

Опубликована: Июль 7, 2022

Язык: Английский

Процитировано

48

Engineering Orthogonal Upconversion through Selective Excitation in a Single Nanoparticle DOI

Jinshu Huang,

Zhengce An,

Yan Long

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(18)

Опубликована: Фев. 20, 2023

Abstract Orthogonal upconversion with color‐switchable emissions under different excitation conditions provides new chances to diverse frontier applications of luminescent materials. However, the previous orthogonal systems compulsorily require precise control spatial distributions dopants and host compositions avoid spectral cross‐talk, greatly limiting their synthesis application. Herein, a conceptual design is presented realize by selectively activating sensitizers activators in nanostructure. In detail, 915 nm laser, instead mostly used 980 nm, adopted activate sensitizer Yb 3+ because broad 2 F 5/2 ← 7/2 absorption band; while it non‐responsive Er , consequently avoiding cross‐talk due simultaneous activation both irradiation as shown works. Such selective strategy able red/green, blue/red, blue/green single nanoparticle simply altering wavelength from 1530 nm. More interestingly, further allows for full‐color output temporal dynamics. The findings suggest facile but effective approach smart materials, showing great potential multi‐level anti‐counterfeiting, information security biological applications.

Язык: Английский

Процитировано

34

Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation DOI Creative Commons
Shumao Xu,

Marzia Momin,

Salahuddin Ahmed

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(42)

Опубликована: Сен. 19, 2023

Abstract Optogenetic modulation of brain neural activity that combines optical and electrical modes in a unitary system has recently gained robust momentum. Controlling illumination spatial coverage, designing light‐activated modulators, developing wireless light delivery data transmission are crucial for maximizing the use neuromodulation. To this end, biocompatible electrodes with enhanced optoelectrical performance, device integration multiplexed addressing, transmission, multimodal operation soft systems have been developed. This review provides an outlook uniformly illuminating large areas while spatiotemporally imaging responses upon stimulation little artifacts. Representative concepts important breakthroughs, such as head‐mounted illumination, multiple implanted fibers, micro‐light‐delivery devices, discussed. Examples techniques incorporate electrophysiological monitoring presented. Challenges perspectives posed further research efforts toward high‐density interface modulation, potential nonpharmacological neurological disease treatments stimulation.

Язык: Английский

Процитировано

30