Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Design, optimization, and nanotechnology of antimicrobial peptides: From exploration to applications

Nano Today, Год журнала: 2021, Номер 39, С. 101229 - 101229

Опубликована: Июль 5, 2021

Язык: Английский

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Understanding bacterial biofilms: From definition to treatment strategies

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Апрель 6, 2023

Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms significant problem treating bacterial infections and one of the main reasons for persistence infections. They can exhibit increased resistance to classical antibiotics cause disease through device-related non-device (tissue) -associated infections, posing severe threat global health issues. Therefore, early detection search new alternative treatments essential suppressing biofilm-associated In this paper, we systematically reviewed biofilms, associated methods, potential treatment strategies, aiming provide researchers with latest progress biofilms.

Язык: Английский

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Dendrimer-based drug delivery systems: history, challenges, and latest developments

Journal of Biological Engineering, Год журнала: 2022, Номер 16(1)

Опубликована: Июль 25, 2022

Abstract Since the first dendrimer was reported in 1978 by Fritz Vögtle, research has grown exponentially, from synthesis to application past four decades. The distinct structure characteristics of dendrimers include nanoscopic size, multi-functionalized surface, high branching, cavernous interior, and so on, making themselves ideal drug delivery vehicles. This mini review article provides a brief overview dendrimer’s history properties latest developments as systems. focuses on progress applications gene carriers, including 1) active release strategies dissociate drug/gene response stimuli; 2) size-adaptive charge reversal systems that can better take advantage size surface dendrimer; 3) bulk micro/nano gel recent advances formulations may lead generation new products enable development novel combination therapies.

Язык: Английский

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Advances of peptides for antibacterial applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2021, Номер 202, С. 111682 - 111682

Опубликована: Март 9, 2021

Язык: Английский

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Space-Selective Chemodynamic Therapy of CuFe₅O₈ Nanocubes for Implant-Related Infections

ACS Nano, Год журнала: 2020, Номер 14(10), С. 13391 - 13405

Опубликована: Сен. 15, 2020

Implant-related infections (IRIs) are a serious complication after orthopedic surgery, especially when biofilm develops and establishes physical chemical barriers protecting bacteria from antibiotics the hosts local immune system. Effectively eliminating biofilms is essential but difficult, as it requires not only breaking barrier also changing that induces an immunosuppressive microenvironment. Herein, tailored to microenvironment (BME), we proposed space-selective chemodynamic therapy (CDT) strategy combat IRIs using metastable CuFe5O8 nanocubes (NCs) smart Fenton-like reaction catalysts whose activity can be regulated by pH H2O2 concentration. In biofilm, extracellular DNA (eDNA) was cleaved high levels of hydroxyl radicals (•OH) catalyzed NCs, thereby disrupting rigid biofilm. Outside with relatively higher lower concentration, generated •OH effectively reversed inducing pro-inflammatory macrophage polarization. Biofilm fragments exposed were then persistently eliminated through collaboration immunity •OH. The spatially selective activation CDT synergistic immunomodulation exerted excellent effects on treatment in vitro vivo. anti-infection expected provide method conquer IRIs.

Язык: Английский

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Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

Advanced Materials, Год журнала: 2021, Номер 33(33)

Опубликована: Июль 3, 2021

Clinical treatment of pathogenic infection has emerged as a growing challenge in global public health. Such is currently limited to antibiotics, but abuse antibiotics have induced multidrug resistance and high fatality rates anti-infection therapies. Thus, it vital develop alternative bactericidal agents open novel disinfection pathways. Drawing inspiration from elements the human immune system that show great potential for controlling pathogens or regulating cell apoptosis, design biocatalytic nanomaterials (BCNs) provided unrivaled opportunities future antibacterial More significantly, BCNs exhibit various superior properties cells natural enzymes, such higher performance, extraordinary stability against harsh conditions, scalable production. In this review, most recent efforts toward developing BCN-based biomedical applications combating bacterial infections are focused upon. BCNs' mechanisms, classification BCNs, activities can be triggered augmented by energy conversion, eradication biofilms with systematically introduced discussed. The current challenges prospects also summarized. It anticipated review will provide new therapeutic insights into bacteria offer significant designing nanomaterials.

Язык: Английский

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A comprehensive review on various techniques used for synthesizing nanoparticles

Journal of Materials Research and Technology, Год журнала: 2023, Номер 27, С. 1739 - 1763

Опубликована: Окт. 4, 2023

Nature is still the main focus of scientific and technological research, particularly in nanotechnology because its remarkable properties; has acquired much interest recent years. This review focuses on up-to-date overview classification nanoparticles, characterization, methods preparation, characterization application nanoparticles. Initial section gives insight various techniques for synthesis encompassing both bottom-up top-down approaches. Different nanoparticles are discussed details. Highlighting importance controlling shape, size, composition to develop enhance properties These include enhanced surface area, unique optical, electronic, magnetic characteristics, as well improved mechanical properties. Understanding these attributes essential harnessing different applications effectively. Broad spectrum also discussed. Additionally, have found catalysis, environmental remediation, antimicrobial coatings, contributing sustainable development protection. Overall, represent a progressive area research with tremendous potential innovation societal impact. Our evaluation will serve solid reference, assisting community comprehend topic better by showing role each technique comparable manner. As field constantly evolving, this incorporates latest developments, advancements up time publication. A comprehensive understanding their properties, decisive realizing full industrial domains.

Язык: Английский

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Therapeutic strategies against bacterial biofilms

Fundamental Research, Год журнала: 2021, Номер 1(2), С. 193 - 212

Опубликована: Фев. 21, 2021

The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. formation biofilms is one the main reasons resistance. complexity chemical composition physical structure elimination mature difficult problem. highly antibiotic resistant property urgently calls for potent antimicrobial agents novel antibiofilm strategies. Researchers have made lot efforts in this field. Here we review current strategies eliminate progress related drug delivery nanosystems, with aim inspiring researchers design new systems.

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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