Patients
with
methicillin-resistant
Staphylococcus
aureus
(MRSA)
infections
may
have
higher
death
rates
than
those
non-drug-resistant
infections.
Nanozymes
offer
a
promising
approach
to
eliminating
bacteria
by
producing
reactive
oxygen
species.
However,
most
of
the
conventional
nanozyme
technologies
encounter
significant
challenges
respect
size,
composition,
and
naturally
low
number
active
sites.
The
present
study
synthesizes
iron-single-atom
structure
(Fe-SAC)
via
nitrogen
doped-carbon,
Fe-N
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Journal of Biological Engineering,
Год журнала:
2022,
Номер
16(1)
Опубликована: Июль 25, 2022
Abstract
Since
the
first
dendrimer
was
reported
in
1978
by
Fritz
Vögtle,
research
has
grown
exponentially,
from
synthesis
to
application
past
four
decades.
The
distinct
structure
characteristics
of
dendrimers
include
nanoscopic
size,
multi-functionalized
surface,
high
branching,
cavernous
interior,
and
so
on,
making
themselves
ideal
drug
delivery
vehicles.
This
mini
review
article
provides
a
brief
overview
dendrimer’s
history
properties
latest
developments
as
systems.
focuses
on
progress
applications
gene
carriers,
including
1)
active
release
strategies
dissociate
drug/gene
response
stimuli;
2)
size-adaptive
charge
reversal
systems
that
can
better
take
advantage
size
surface
dendrimer;
3)
bulk
micro/nano
gel
recent
advances
formulations
may
lead
generation
new
products
enable
development
novel
combination
therapies.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Апрель 6, 2023
Bacterial
biofilms
are
complex
microbial
communities
encased
in
extracellular
polymeric
substances.
Their
formation
is
a
multi-step
process.
Biofilms
significant
problem
treating
bacterial
infections
and
one
of
the
main
reasons
for
persistence
infections.
They
can
exhibit
increased
resistance
to
classical
antibiotics
cause
disease
through
device-related
non-device
(tissue)
-associated
infections,
posing
severe
threat
global
health
issues.
Therefore,
early
detection
search
new
alternative
treatments
essential
suppressing
biofilm-associated
In
this
paper,
we
systematically
reviewed
biofilms,
associated
methods,
potential
treatment
strategies,
aiming
provide
researchers
with
latest
progress
biofilms.
ACS Nano,
Год журнала:
2020,
Номер
14(10), С. 13391 - 13405
Опубликована: Сен. 15, 2020
Implant-related
infections
(IRIs)
are
a
serious
complication
after
orthopedic
surgery,
especially
when
biofilm
develops
and
establishes
physical
chemical
barriers
protecting
bacteria
from
antibiotics
the
hosts
local
immune
system.
Effectively
eliminating
biofilms
is
essential
but
difficult,
as
it
requires
not
only
breaking
barrier
also
changing
that
induces
an
immunosuppressive
microenvironment.
Herein,
tailored
to
microenvironment
(BME),
we
proposed
space-selective
chemodynamic
therapy
(CDT)
strategy
combat
IRIs
using
metastable
CuFe5O8
nanocubes
(NCs)
smart
Fenton-like
reaction
catalysts
whose
activity
can
be
regulated
by
pH
H2O2
concentration.
In
biofilm,
extracellular
DNA
(eDNA)
was
cleaved
high
levels
of
hydroxyl
radicals
(•OH)
catalyzed
NCs,
thereby
disrupting
rigid
biofilm.
Outside
with
relatively
higher
lower
concentration,
generated
•OH
effectively
reversed
inducing
pro-inflammatory
macrophage
polarization.
Biofilm
fragments
exposed
were
then
persistently
eliminated
through
collaboration
immunity
•OH.
The
spatially
selective
activation
CDT
synergistic
immunomodulation
exerted
excellent
effects
on
treatment
in
vitro
vivo.
anti-infection
expected
provide
method
conquer
IRIs.
Advanced Materials,
Год журнала:
2021,
Номер
33(33)
Опубликована: Июль 3, 2021
Clinical
treatment
of
pathogenic
infection
has
emerged
as
a
growing
challenge
in
global
public
health.
Such
is
currently
limited
to
antibiotics,
but
abuse
antibiotics
have
induced
multidrug
resistance
and
high
fatality
rates
anti-infection
therapies.
Thus,
it
vital
develop
alternative
bactericidal
agents
open
novel
disinfection
pathways.
Drawing
inspiration
from
elements
the
human
immune
system
that
show
great
potential
for
controlling
pathogens
or
regulating
cell
apoptosis,
design
biocatalytic
nanomaterials
(BCNs)
provided
unrivaled
opportunities
future
antibacterial
More
significantly,
BCNs
exhibit
various
superior
properties
cells
natural
enzymes,
such
higher
performance,
extraordinary
stability
against
harsh
conditions,
scalable
production.
In
this
review,
most
recent
efforts
toward
developing
BCN-based
biomedical
applications
combating
bacterial
infections
are
focused
upon.
BCNs'
mechanisms,
classification
BCNs,
activities
can
be
triggered
augmented
by
energy
conversion,
eradication
biofilms
with
systematically
introduced
discussed.
The
current
challenges
prospects
also
summarized.
It
anticipated
review
will
provide
new
therapeutic
insights
into
bacteria
offer
significant
designing
nanomaterials.
Journal of Materials Research and Technology,
Год журнала:
2023,
Номер
27, С. 1739 - 1763
Опубликована: Окт. 4, 2023
Nature
is
still
the
main
focus
of
scientific
and
technological
research,
particularly
in
nanotechnology
because
its
remarkable
properties;
has
acquired
much
interest
recent
years.
This
review
focuses
on
up-to-date
overview
classification
nanoparticles,
characterization,
methods
preparation,
characterization
application
nanoparticles.
Initial
section
gives
insight
various
techniques
for
synthesis
encompassing
both
bottom-up
top-down
approaches.
Different
nanoparticles
are
discussed
details.
Highlighting
importance
controlling
shape,
size,
composition
to
develop
enhance
properties
These
include
enhanced
surface
area,
unique
optical,
electronic,
magnetic
characteristics,
as
well
improved
mechanical
properties.
Understanding
these
attributes
essential
harnessing
different
applications
effectively.
Broad
spectrum
also
discussed.
Additionally,
have
found
catalysis,
environmental
remediation,
antimicrobial
coatings,
contributing
sustainable
development
protection.
Overall,
represent
a
progressive
area
research
with
tremendous
potential
innovation
societal
impact.
Our
evaluation
will
serve
solid
reference,
assisting
community
comprehend
topic
better
by
showing
role
each
technique
comparable
manner.
As
field
constantly
evolving,
this
incorporates
latest
developments,
advancements
up
time
publication.
A
comprehensive
understanding
their
properties,
decisive
realizing
full
industrial
domains.
Fundamental Research,
Год журнала:
2021,
Номер
1(2), С. 193 - 212
Опубликована: Фев. 21, 2021
The
emergence
of
multi-drug
resistance
makes
bacterial
infection
a
major
threat
to
public
health
and
economy.
formation
biofilms
is
one
the
main
reasons
resistance.
complexity
chemical
composition
physical
structure
elimination
mature
difficult
problem.
highly
antibiotic
resistant
property
urgently
calls
for
potent
antimicrobial
agents
novel
antibiofilm
strategies.
Researchers
have
made
lot
efforts
in
this
field.
Here
we
review
current
strategies
eliminate
progress
related
drug
delivery
nanosystems,
with
aim
inspiring
researchers
design
new
systems.
